DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kel and Klhl20

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_008767871.1	Gene:	Klhl20 / 304920	RGDID:	1309490	Length:	633	Species:	Rattus norvegicus

Alignment Length:	604	Identity:	255/604 - (42%)
Similarity:	375/604 - (62%)	Gaps:	17/604 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 EGSGLERGSCLLRYASQNSLDESSQKHVQRPNGKERGTVGQ-----YSNEQHTARSFDAMNEMRK 152
            ||..:.|  |......:..:|.:|:..:..||....| |.|     |.:::|..::.:.:|.:||
  Rat    26 EGKPMRR--CTNIRPGETGMDVTSRCTLGDPNKLPEG-VPQPARMPYISDKHPRQTLEVINLLRK 87

  Fly   153 QKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFT-SFEESRQARITLQSVDARALELLIDYVYT 216
            .::||||:||....:|:|||::|::|||||.|||| ...||||..:.::.:|.||:|||||:.||
  Rat    88 HRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 152

  Fly   217 ATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYI 281
            :.:.|.|.|||.||.||.||||.::::|||:||:.|||.|||||||.|||.|:|.|||..|:.:.
  Rat   153 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFT 217

  Fly   282 EQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVR 346
            :.:|.||::.:||:.|...|:|.:|.:|.::|.:||:|:..|:||::|.:..|......:::|||
  Rat   218 QHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVR 282

  Fly   347 LPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYHLLPTE---TKSARTVPRKPVGMPKILLVI 408
            ||.||.:::...|..:.|::.:..|::|:.||..|.|||.|   .:..||.||||:...::|..:
  Rat   283 LPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAV 347

  Fly   409 GGQ-APKAIRSVEWYDLREEKWYQAAEMPNRRCRSGLSVLGDKVYAVGGFNGSLRVRTVDVYDPA 472
            ||. :..||.|||.||.:..:|...|.|..|||..|:|||.|.:|||||.:||..:.:|:.|||.
  Rat   348 GGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPK 412

  Fly   473 TDQW-ANCSNMEARRSTLGVAVLNGCIYAVGGFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSV 536
            |:|| ::.:.....|:::|||||.|.:|||||.||.:.|:..|.||||.:.|..:|||||||..|
  Rat   413 TNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGV 477

  Fly   537 GVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHD 601
            .|.|:.|.||||||.||.:.  |::||||||..:.|..:|.|.:||...|..|..:::|||||.|
  Rat   478 AVAVLGGFLYAVGGSDGTSP--LNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRD 540

  Fly   602 GPMVRRSVEAYDCETNSWRSVADMSYCRRNAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSW 666
            ......|.|.|:..||.|..|..|:..|...|:...:|.|..|||.|||:.|.::||:.||:::|
  Rat   541 DTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW 605

  Fly   667 RILPALMTIGRSYAGVCMI 685
            |:... |...|...||.:|
  Rat   606 RLYGG-MNYRRLGGGVGVI 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	54/103 (52%)
		PHA03098	150..675	CDD:222983	237/530 (45%)
		BACK	258..359	CDD:285009	40/100 (40%)
		Kelch	405..449	CDD:128874	20/44 (45%)
		KELCH repeat	439..482	CDD:276965	21/43 (49%)
		Kelch	450..496	CDD:128874	20/46 (43%)
		KELCH repeat	486..530	CDD:276965	23/43 (53%)
		Kelch	497..543	CDD:128874	24/45 (53%)
		KELCH repeat	533..580	CDD:276965	23/46 (50%)
		Kelch	544..592	CDD:128874	22/47 (47%)
		KELCH repeat	582..626	CDD:276965	16/43 (37%)
		Kelch	594..639	CDD:128874	16/44 (36%)
		KELCH repeat	629..674	CDD:276965	17/44 (39%)
		Kelch	640..687	CDD:128874	19/46 (41%)
Klhl20	XP_008767871.1	BTB	83..186	CDD:279045	54/102 (53%)
		PHA03098	87..610	CDD:222983	235/524 (45%)
		BACK	194..295	CDD:285009	40/100 (40%)
		Kelch	343..389	CDD:128874	20/45 (44%)
		KELCH repeat	379..423	CDD:276965	21/43 (49%)
		Kelch	390..437	CDD:128874	20/46 (43%)
		KELCH repeat	427..471	CDD:276965	23/43 (53%)
		Kelch	439..484	CDD:128874	24/44 (55%)
		KELCH repeat	474..519	CDD:276965	23/46 (50%)
		Kelch	486..531	CDD:128874	22/46 (48%)
		KELCH repeat	521..564	CDD:276965	16/42 (38%)
		Kelch	533..578	CDD:128874	16/44 (36%)
		Kelch_1	567..612	CDD:279660	17/45 (38%)
		KELCH repeat	568..613	CDD:276965	18/45 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820