Protein Alignment kel and Klhl24

DIOPT Version :10

• Sequence 1: NP_476589.4
• Gene: kel / 35084
• FlyBaseID: FBgn0001301
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_852138.2
• Gene: Klhl24 / 303803
• RGDID: 727971
• Length: 600
• Species: Rattus norvegicus
• Alignment Length: 567
• Identity: 180/567 - (31%)
• Similarity: 281/567 - (49%)
• Gaps: 40/567 - (7%)

  Fly   135 SNEQHTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMF-TSFEESRQARIT 198
            |...|........||.|..:...|||:..:..|...||.||::||.||.||| ....|||:..:.
  Rat    44 SGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVE 108

  Fly   199 LQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIRE 263
            :..:.|.|:|..:.||||..|::..:|||.|...::|.|::.:||||..||:.|||..|||||:.
  Rat   109 INGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQR 173

  Fly   264 FADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWLR 328
            |||.|:...|....:|:..|.|.:|.|.:|||.|..:::|..|.:|.:.:..||.|:|.|:.|:.
  Rat   174 FADTHSLKTLFTKCKTFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVY 238

  Fly   329 YDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYHLLPTETKSART 393
            ..|.:|......|:.|||||.|...|..|.|:.:.|::.:..|..|:.||..||:|..|..|.||
  Rat   239 RAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRT 303

  Fly   394 VPRKPVGMPKILLVIGG-------QAPKAIRSVEWYDLREEKWYQAAEMPN-RRCRSGLSVLGDK 450
            .||:..|..::::|:||       ..|    ..|.||....:|...|::|. .:....:..|.:.
  Rat   304 RPRRSTGYSEVIVVVGGCERVGGFNLP----YTECYDPVTGEWKSLAKLPEFTKSEYAVCALRND 364

  Fly   451 VYAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARRSTLGVAVLNGCIYAVGGFDGTTGLSSAEM 515
            :...|   |.:..|.|.:|:...:.|...:::...|....:|||.|.:|.|||:||...|||.|.
  Rat   365 ILVSG---GRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVEC 426

  Fly   516 YDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAV-GGYDGFTRQCLSSVERYNPDTDTWVNVAEMS 579
            ||..::.|..:|.:....||..|....|.|:.: ||.|..|  |...|:.|:|:|::|:..|.:.
  Rat   427 YDSFSNRWTEVAPLKEAVSSPAVTSCIGKLFVIGGGPDDNT--CSDKVQSYDPETNSWLLRAAIP 489

  Fly   580 SRRSGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETNSWRSVADMSYCRRNAGVVAHDGLLYVV 644
            ..:.......|||::|..||     :.::|..||...:.|..|.:....:.|.|:...:|.:|::
  Rat   490 IAKRCITAVSLNNLIYVAGG-----LTKAVYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYIL 549

  Fly   645 GG--DDGTSNLASVEVYCPDSDSWRILPALMTIGRSYAGVCMIDKPM 689
            ||  ::|.   |:..:.|.|       ||...|    .||..:.:|:
  Rat   550 GGRRENGE---ATDTILCYD-------PATSII----TGVAAMPRPV 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB_POZ_KLHL2-like	136..255	CDD:349544	44/119 (37%)
		PHA03098	150..675	CDD:222983	172/536 (32%)
		KELCH repeat	439..482	CDD:276965	7/42 (17%)
		KELCH repeat	486..530	CDD:276965	19/43 (44%)
		KELCH repeat	533..580	CDD:276965	16/47 (34%)
		KELCH repeat	582..626	CDD:276965	11/43 (26%)
		KELCH repeat	629..674	CDD:276965	12/46 (26%)
Klhl24	NP_852138.2	BTB_POZ_KLHL24_KRIP6	48..168	CDD:349562	45/119 (38%)
		PHA03098	62..566	CDD:222983	168/520 (32%)
		Kelch 1	314..363		11/52 (21%)
		KELCH repeat	354..393	CDD:276965	7/41 (17%)
		Kelch 2	365..407		10/44 (23%)
		KELCH repeat	397..441	CDD:276965	19/43 (44%)
		Kelch 3	408..454		17/45 (38%)
		KELCH repeat	444..489	CDD:276965	16/46 (35%)
		Kelch 4	456..502		13/47 (28%)
		KELCH repeat	492..529	CDD:276965	11/41 (27%)
		Kelch 5	504..544		10/44 (23%)
		KELCH repeat	536..578	CDD:276965	15/55 (27%)
		Kelch	545..591	CDD:128874	13/52 (25%)
		Kelch 6	546..592		13/51 (25%)