DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kel and Klhl1

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001381602.1	Gene:	Klhl1 / 290426	RGDID:	1307452	Length:	750	Species:	Rattus norvegicus

Alignment Length:	678	Identity:	260/678 - (38%)
Similarity:	366/678 - (53%)	Gaps:	54/678 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QQQQQGQNPQQPA---------QNEGGAGAEFVAPPPGLGAAVGVAAMQQRNRLLQQQQQQHHHH 87
            ||...||..||||         :.|...|.:|..|             |.:...|::.|.:....
  Rat   106 QQGAPGQGTQQPARTLFYVESLEEEVVTGMDFPGP-------------QDKGLALKELQAEPASS 157

  Fly    88 QNPAAEGSGLERGSCLLRYASQNSLDESSQKHVQRPNGKERGTVGQYSNEQHTARSFDAMNEMRK 152
            .....||.|....:.......|:.||.||.:..             |....|..:||..|....|
  Rat   158 IQATGEGCGHRLTTTNHSLTPQSDLDSSSSEEF-------------YQAVHHAEQSFRKMENYLK 209

  Fly   153 QKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTS-FEESRQARITLQSVDARALELLIDYVYT 216
            |:|||||||:..:.:|.|||:||:|.|.||.||||| ..|::|..|.::.:|..||..|:.:.||
  Rat   210 QQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYT 274

  Fly   217 ATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYI 281
            ..:|:.||.::.||.||.||||..|.:.||.||...|..|||||||.|||...|:||:..|.:|.
  Rat   275 GCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYT 339

  Fly   282 EQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVR 346
            .::..|||:..|||.|..|::..|:.:|.::||:||.::..::.|::||:..|....|:|:..:|
  Rat   340 MENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCGDLSMLLAFIR 404

  Fly   347 LPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYHLLP---TETKSARTVPRK-PVGMPKILLV 407
            ||.|..:.:.. ::...|.:.::.|:.||:||:.|||||   |..:|.||.||| .||   .|..
  Rat   405 LPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVG---TLYA 465

  Fly   408 IGG-QAPKAIRSVEWYDLREEKWYQAAEMPNRRCRSGLSVLGDKVYAVGGFNGSLRVRTVDVYDP 471
            :|| ...|...::|.||||...|.||..|..||.:.|::|:.||::.:||.:|...:.||:.|:|
  Rat   466 VGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNP 530

  Fly   472 ATDQWANCSNMEARRSTLGVAVLNGCIYAVGGFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSV 536
            .|..|.....|...|..|||.||.|.||||||.||.:.|::.|.:||::..|.::||||..||:|
  Rat   531 KTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIARSTV 595

  Fly   537 GVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHD 601
            ||..::|.||:|||.||  ..||||:|.|:|.|:.|...|.|..||.|.||...:..||||||||
  Rat   596 GVAALNGKLYSVGGRDG--SSCLSSMEYYDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGGHD 658

  Fly   602 GPMVRRS------VEAYDCETNSWRSVADMSYCRRNAGVVAHDGLLYVVGGDDGTSNLASVEVYC 660
            .|.....      ||.||.:|::|..||.:|..|...||......||.|||.||.:.|.::|.|.
  Rat   659 APASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYD 723

  Fly   661 PDSDSWRILPALMTIGRSYAGVCMIDKP 688
            |.::.|..: |.:.|||:.|.|.:|.:|
  Rat   724 PQTNEWTQM-ASLNIGRAGACVVVIKQP 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	49/103 (48%)
		PHA03098	150..675	CDD:222983	225/536 (42%)
		BACK	258..359	CDD:285009	37/100 (37%)
		Kelch	405..449	CDD:128874	17/44 (39%)
		KELCH repeat	439..482	CDD:276965	14/42 (33%)
		Kelch	450..496	CDD:128874	17/45 (38%)
		KELCH repeat	486..530	CDD:276965	22/43 (51%)
		Kelch	497..543	CDD:128874	22/45 (49%)
		KELCH repeat	533..580	CDD:276965	24/46 (52%)
		Kelch	544..592	CDD:128874	23/47 (49%)
		KELCH repeat	582..626	CDD:276965	21/49 (43%)
		Kelch	594..639	CDD:128874	21/50 (42%)
		KELCH repeat	629..674	CDD:276965	16/44 (36%)
		Kelch	640..687	CDD:128874	19/46 (41%)
Klhl1	NP_001381602.1	PHA03098	208..730	CDD:222983	223/527 (42%)
		KELCH repeat	498..541	CDD:276965	14/42 (33%)
		KELCH repeat	545..589	CDD:276965	22/43 (51%)
		KELCH repeat	592..635	CDD:276965	23/44 (52%)
		KELCH repeat	639..689	CDD:276965	21/49 (43%)
		KELCH repeat	692..736	CDD:276965	16/44 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920