Protein Alignment kel and Klhl1

DIOPT Version :10

• Sequence 1: NP_476589.4
• Gene: kel / 35084
• FlyBaseID: FBgn0001301
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_001381602.1
• Gene: Klhl1 / 290426
• RGDID: 1307452
• Length: 750
• Species: Rattus norvegicus
• Alignment Length: 678
• Identity: 260/678 - (38%)
• Similarity: 366/678 - (53%)
• Gaps: 54/678 - (7%)

  Fly    32 QQQQQGQNPQQPA---------QNEGGAGAEFVAPPPGLGAAVGVAAMQQRNRLLQQQQQQHHHH 87
            ||...||..||||         :.|...|.:|..|             |.:...|::.|.:....
  Rat   106 QQGAPGQGTQQPARTLFYVESLEEEVVTGMDFPGP-------------QDKGLALKELQAEPASS 157

  Fly    88 QNPAAEGSGLERGSCLLRYASQNSLDESSQKHVQRPNGKERGTVGQYSNEQHTARSFDAMNEMRK 152
            .....||.|....:.......|:.||.||.:..             |....|..:||..|....|
  Rat   158 IQATGEGCGHRLTTTNHSLTPQSDLDSSSSEEF-------------YQAVHHAEQSFRKMENYLK 209

  Fly   153 QKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTS-FEESRQARITLQSVDARALELLIDYVYT 216
            |:|||||||:..:.:|.|||:||:|.|.||.||||| ..|::|..|.::.:|..||..|:.:.||
  Rat   210 QQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYT 274

  Fly   217 ATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYI 281
            ..:|:.||.::.||.||.||||..|.:.||.||...|..|||||||.|||...|:||:..|.:|.
  Rat   275 GCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYT 339

  Fly   282 EQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVR 346
            .::..|||:..|||.|..|::..|:.:|.::||:||.::..::.|::||:..|....|:|:..:|
  Rat   340 MENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCGDLSMLLAFIR 404

  Fly   347 LPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYHLLP---TETKSARTVPRK-PVGMPKILLV 407
            ||.|..:.:.. ::...|.:.::.|:.||:||:.|||||   |..:|.||.||| .||   .|..
  Rat   405 LPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVG---TLYA 465

  Fly   408 IGG-QAPKAIRSVEWYDLREEKWYQAAEMPNRRCRSGLSVLGDKVYAVGGFNGSLRVRTVDVYDP 471
            :|| ...|...::|.||||...|.||..|..||.:.|::|:.||::.:||.:|...:.||:.|:|
  Rat   466 VGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNP 530

  Fly   472 ATDQWANCSNMEARRSTLGVAVLNGCIYAVGGFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSV 536
            .|..|.....|...|..|||.||.|.||||||.||.:.|::.|.:||::..|.::||||..||:|
  Rat   531 KTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIARSTV 595

  Fly   537 GVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHD 601
            ||..::|.||:|||.||  ..||||:|.|:|.|:.|...|.|..||.|.||...:..||||||||
  Rat   596 GVAALNGKLYSVGGRDG--SSCLSSMEYYDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGGHD 658

  Fly   602 GPMVRRS------VEAYDCETNSWRSVADMSYCRRNAGVVAHDGLLYVVGGDDGTSNLASVEVYC 660
            .|.....      ||.||.:|::|..||.:|..|...||......||.|||.||.:.|.::|.|.
  Rat   659 APASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYD 723

  Fly   661 PDSDSWRILPALMTIGRSYAGVCMIDKP 688
            |.::.|..: |.:.|||:.|.|.:|.:|
  Rat   724 PQTNEWTQM-ASLNIGRAGACVVVIKQP 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB_POZ_KLHL2-like	136..255	CDD:349544	54/119 (45%)
		PHA03098	150..675	CDD:222983	225/536 (42%)
		KELCH repeat	439..482	CDD:276965	14/42 (33%)
		KELCH repeat	486..530	CDD:276965	22/43 (51%)
		KELCH repeat	533..580	CDD:276965	24/46 (52%)
		KELCH repeat	582..626	CDD:276965	21/49 (43%)
		KELCH repeat	629..674	CDD:276965	16/44 (36%)
Klhl1	NP_001381602.1	PHA03098	208..730	CDD:222983	223/527 (42%)
		KELCH repeat	498..541	CDD:276965	14/42 (33%)
		KELCH repeat	545..589	CDD:276965	22/43 (51%)
		KELCH repeat	592..635	CDD:276965	23/44 (52%)
		KELCH repeat	639..689	CDD:276965	21/49 (43%)
		KELCH repeat	692..736	CDD:276965	16/44 (36%)