DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and Klhl12

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_038946329.1	Gene:	Klhl12 / 266772	RGDID:	628717	Length:	592	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	237/567 - (41%)
Similarity:	338/567 - (59%)	Gaps:	29/567 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 HTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTS--------FEESRQA 195
            |.....::||.:||...||||.|..:..:..|||:|||:||.||.|||||        ..|..:.
  Rat    32 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSEVNASLCYLSEKGKP 96

  Fly   196 RITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLG 260
            .:.:|.:.|..:|:|:|:|||.||.|..:|||.||.||.||||..|:.|||:||::|||.|||||
  Rat    97 YVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLG 161

  Fly   261 IREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIA 325
            ||:||:.|.||:|:..||.:.::||.||:|.:||:.||..:|..||..|.|.|.:||.|:|.||.
  Rat   162 IRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVIN 226

  Fly   326 WLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYHLLPTETKS 390
            |:::....||:....|:::||:|.|:..|||..:|.|..:..::.|::|:.||..:||.| |.:|
  Rat   227 WVKHAKKEREESLPDLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRP-ELRS 290

  Fly   391 ARTVP--RKPVGMPKILLVIGG----QAPKAIRSVEWYDLREEKWYQAAEMPN--RRCRSGLSV- 446
            ....|  |..:|..::|||:||    |:|  |..||.||.:.::|   :.:|:  |:.|...||
  Rat   291 QMQGPRTRARLGANEVLLVVGGFGSQQSP--IDVVEKYDPKTQEW---SFLPSITRKRRYVASVS 350

  Fly   447 LGDKVYAVGGFNGSLRVRTVDVYDPATDQ---WANCSNMEARRSTLGVAVLNGCIYAVGGFDGTT 508
            |.|::|.:||::|..|:.:|:..|...|:   |.:.:.|..||...|...|...||..|||||:.
  Rat   351 LHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSR 415

  Fly   509 GLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDTWV 573
            ..:|.|.|||..|.|..:..|.|.|...|:.|..|::|.:|||||.  ..|:|||:|:|.|..|.
  Rat   416 RHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGIIYCLGGYDGL--NILNSVEKYDPHTGHWT 478

  Fly   574 NVAEMSSRRSGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETNSWRSVADMSYCRRNAGVVAHD 638
            ||..|:::||||||.:||:.:|.|||.||.....|||||:..|:||.:|..|:..|...|.....
  Rat   479 NVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLR 543

  Fly   639 GLLYVVGGDDGTSNLASVEVYCPDSDSWRILPALMTIGRSYAGVCMI 685
            |.||.:.|.||.|.|:|:|.|.|..|||.:: |.|...|..||||::
  Rat   544 GRLYAIAGYDGNSLLSSIECYDPIIDSWEVV-ASMGTQRCDAGVCVL 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	52/110 (47%)
		PHA03098	150..675	CDD:222983	229/544 (42%)
		BACK	258..359	CDD:285009	45/100 (45%)
		Kelch	405..449	CDD:128874	19/50 (38%)
		KELCH repeat	439..482	CDD:276965	14/46 (30%)
		Kelch	450..496	CDD:128874	14/48 (29%)
		KELCH repeat	486..530	CDD:276965	17/43 (40%)
		Kelch	497..543	CDD:128874	19/45 (42%)
		KELCH repeat	533..580	CDD:276965	21/46 (46%)
		Kelch	544..592	CDD:128874	24/47 (51%)
		KELCH repeat	582..626	CDD:276965	23/43 (53%)
		Kelch	594..639	CDD:128874	18/44 (41%)
		KELCH repeat	629..674	CDD:276965	18/44 (41%)
		Kelch	640..687	CDD:128874	21/46 (46%)
Klhl12	XP_038946329.1	BTB_POZ_KLHL12_C3IP1_DKIR	29..159	CDD:349551	58/126 (46%)
		PHA03098	63..574	CDD:222983	220/518 (42%)
		BACK_KLHL12	154..289	CDD:350527	59/135 (44%)
		KELCH repeat	298..339	CDD:276965	16/45 (36%)
		KELCH repeat	343..389	CDD:276965	14/45 (31%)
		KELCH repeat	393..436	CDD:276965	17/42 (40%)
		KELCH repeat	440..483	CDD:276965	20/44 (45%)
		KELCH repeat	487..531	CDD:276965	23/43 (53%)
		KELCH repeat	534..579	CDD:276965	19/45 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350342
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750