Protein Alignment kel and Klhl12

DIOPT Version :10

• Sequence 1: NP_476589.4
• Gene: kel / 35084
• FlyBaseID: FBgn0001301
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: XP_038946329.1
• Gene: Klhl12 / 266772
• RGDID: 628717
• Length: 592
• Species: Rattus norvegicus
• Alignment Length: 568
• Identity: 236/568 - (41%)
• Similarity: 339/568 - (59%)
• Gaps: 31/568 - (5%)

  Fly   139 HTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTS--------FEESRQA 195
            |.....::||.:||...||||.|..:..:..|||:|||:||.||.|||||        ..|..:.
  Rat    32 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSEVNASLCYLSEKGKP 96

  Fly   196 RITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLG 260
            .:.:|.:.|..:|:|:|:|||.||.|..:|||.||.||.||||..|:.|||:||::|||.|||||
  Rat    97 YVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLG 161

  Fly   261 IREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIA 325
            ||:||:.|.||:|:..||.:.::||.||:|.:||:.||..:|..||..|.|.|.:||.|:|.||.
  Rat   162 IRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVIN 226

  Fly   326 WLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYHLLP---TE 387
            |:::....||:....|:::||:|.|:..|||..:|.|..:..::.|::|:.||..:||.|   ::
  Rat   227 WVKHAKKEREESLPDLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRPELRSQ 291

  Fly   388 TKSARTVPRKPVGMPKILLVIGG----QAPKAIRSVEWYDLREEKWYQAAEMPN--RRCRSGLSV 446
            .:..||  |..:|..::|||:||    |:|  |..||.||.:.::|   :.:|:  |:.|...||
  Rat   292 MQGPRT--RARLGANEVLLVVGGFGSQQSP--IDVVEKYDPKTQEW---SFLPSITRKRRYVASV 349

  Fly   447 -LGDKVYAVGGFNGSLRVRTVDVYDPATDQ---WANCSNMEARRSTLGVAVLNGCIYAVGGFDGT 507
             |.|::|.:||::|..|:.:|:..|...|:   |.:.:.|..||...|...|...||..|||||:
  Rat   350 SLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGS 414

  Fly   508 TGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDTW 572
            ...:|.|.|||..|.|..:..|.|.|...|:.|..|::|.:|||||.  ..|:|||:|:|.|..|
  Rat   415 RRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGIIYCLGGYDGL--NILNSVEKYDPHTGHW 477

  Fly   573 VNVAEMSSRRSGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETNSWRSVADMSYCRRNAGVVAH 637
            .||..|:::||||||.:||:.:|.|||.||.....|||||:..|:||.:|..|:..|...|....
  Rat   478 TNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVL 542

  Fly   638 DGLLYVVGGDDGTSNLASVEVYCPDSDSWRILPALMTIGRSYAGVCMI 685
            .|.||.:.|.||.|.|:|:|.|.|..|||.:: |.|...|..||||::
  Rat   543 RGRLYAIAGYDGNSLLSSIECYDPIIDSWEVV-ASMGTQRCDAGVCVL 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB_POZ_KLHL2-like	136..255	CDD:349544	56/123 (46%)
		PHA03098	150..675	CDD:222983	228/545 (42%)
		KELCH repeat	439..482	CDD:276965	14/46 (30%)
		KELCH repeat	486..530	CDD:276965	17/43 (40%)
		KELCH repeat	533..580	CDD:276965	21/46 (46%)
		KELCH repeat	582..626	CDD:276965	23/43 (53%)
		KELCH repeat	629..674	CDD:276965	18/44 (41%)
Klhl12	XP_038946329.1	BTB_POZ_KLHL12_C3IP1_DKIR	29..159	CDD:349551	58/126 (46%)
		BACK_KLHL12	154..289	CDD:350527	58/134 (43%)
		KELCH repeat	298..339	CDD:276965	16/45 (36%)
		Kelch	306..353	CDD:128874	19/51 (37%)
		NanM	332..589	CDD:442289	107/262 (41%)
		KELCH repeat	343..389	CDD:276965	14/45 (31%)
		KELCH repeat	393..436	CDD:276965	17/42 (40%)
		KELCH repeat	440..483	CDD:276965	20/44 (45%)
		KELCH repeat	487..531	CDD:276965	23/43 (53%)
		KELCH repeat	534..579	CDD:276965	19/45 (42%)