DRSC/TRiP Functional Genomics Resources

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Protein Alignment kel and KBTBD2

DIOPT Version :9

Sequence 1:NP_476589.4 Gene:kel / 35084 FlyBaseID:FBgn0001301 Length:1477 Species:Drosophila melanogaster
Sequence 2:NP_056298.2 Gene:KBTBD2 / 25948 HGNCID:21751 Length:623 Species:Homo sapiens


Alignment Length:620 Identity:168/620 - (27%)
Similarity:272/620 - (43%) Gaps:98/620 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   136 NEQHTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTS-FEESRQARITL 199
            |.::.....:.:....:|:...|::|:.:..|...|:||||:||.||.|||.| ..||:|..:.|
Human    10 NTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHL 74

  Fly   200 QSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREF 264
            ::|||..|:::|.|.||..:.:|:..|:.|...|..||:.||...|.::|..:::|.||:.:..|
Human    75 RNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSF 139

  Fly   265 ADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWLRY 329
            ||:.:|.||...|:..:|..|..|...|.|:.|||:.:|.::.:|.::|..||.|.|..:.||.|
Human   140 ADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEY 204

  Fly   330 DVPMREQFTSLLMEHVRLPFLSKEYITQRV--------DKEILLEGNIVCKNLIIEALTYHLLPT 386
            :...|.|:.|.::..:|:..||:  :|||.        ||.::::|            .|..:|.
Human   205 NTESRSQYLSSVLSQIRIDALSE--VTQRAWFQGLPPNDKSVVVQG------------LYKSMPK 255

  Fly   387 ETKSARTVPRKPVGMPK----ILLVIGGQAPKAIRSVEWYDLREEKWYQAAEMPNRRCRSGLSVL 447
            ..|     ||  :||.|    |.:....:.|.::.|...|..:.||.|:....|....:.|..|.
Human   256 FFK-----PR--LGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVT 313

  Fly   448 GDK-VYAVGG--------FNGS------LRVRTVDV---YDPATDQWANCSNMEARRSTLGVAVL 494
            .|. :|..||        .|.|      ...|||:.   :|...:.|...:.|...|....:...
Human   314 PDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCC 378

  Fly   495 NGCIYAVGG--FDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQ 557
            .|.|||:||  ..|.....:.|.||.:.|.|..::.:..........|||..:|.:         
Human   379 EGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVM--------- 434

  Fly   558 CLSSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGG-H--------------DGPMVRR 607
            .|:.:..|.|.:|:||.:|...:.||.|......:.::.:|| |              ||..|  
Human   435 TLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSV-- 497

  Fly   608 SVEAYDCETNSWRSVADMSYCRRN-----AGVVAHDGLLYVVGGDDGTSNLASVEVYCPD--SDS 665
            :||.||...|.|:..|::...|.:     |.|:::.  |.|...:...:..|....|..|  .|.
Human   498 TVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNS--LCVFMRETHLNERAKYVTYQYDLELDR 560

  Fly   666 WRILP-----ALMTIGRSYAGVCMIDK--PMXMEE 693
            |.:..     .|..:||.:.  |.:.|  |..:||
Human   561 WSLRQHISERVLWDLGRDFR--CTVGKLYPSCLEE 593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kelNP_476589.4 BTB 147..250 CDD:279045 38/103 (37%)
PHA03098 150..675 CDD:222983 160/584 (27%)
BACK 258..359 CDD:285009 34/100 (34%)
Kelch 405..449 CDD:128874 9/43 (21%)
KELCH repeat 439..482 CDD:276965 13/60 (22%)
Kelch 450..496 CDD:128874 12/63 (19%)
KELCH repeat 486..530 CDD:276965 13/45 (29%)
Kelch 497..543 CDD:128874 13/47 (28%)
KELCH repeat 533..580 CDD:276965 11/46 (24%)
Kelch 544..592 CDD:128874 11/47 (23%)
KELCH repeat 582..626 CDD:276965 16/58 (28%)
Kelch 594..639 CDD:128874 16/64 (25%)
KELCH repeat 629..674 CDD:276965 11/56 (20%)
Kelch 640..687 CDD:128874 11/53 (21%)
KBTBD2NP_056298.2 BTB_POZ_KBTBD2_BKLHD1 5..137 CDD:349579 43/126 (34%)
PHA03098 23..516 CDD:222983 149/524 (28%)
BACK_KBTBD2 128..223 CDD:350554 32/94 (34%)
KELCH repeat 310..366 CDD:276965 12/55 (22%)
Kelch 1 317..380 12/62 (19%)
KELCH repeat 370..416 CDD:276965 13/45 (29%)
Kelch 2 381..429 13/47 (28%)
KELCH repeat 419..453 CDD:276965 10/42 (24%)
Kelch 3 431..469 11/46 (24%)
KELCH repeat 459..516 CDD:276965 16/58 (28%)
Kelch 4 470..529 15/60 (25%)
KELCH repeat 519..568 CDD:276965 10/50 (20%)
Kelch 5 535..581 9/47 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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