DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and Gmcl1

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_035948.3	Gene:	Gmcl1 / 23885	MGIID:	1345156	Length:	524	Species:	Mus musculus

Alignment Length:	303	Identity:	68/303 - (22%)
Similarity:	110/303 - (36%)	Gaps:	73/303 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PPPGLGAAVGVAAMQQRNRLLQQQQQQHHHHQNPAAEGSG-----------LERGS---CLLRYA 107
            |.||.|.|.                     .::.|.|.:|           .:|.|   |.....
Mouse    20 PTPGAGGAA---------------------RRSDAGEDAGHSFCYCPGGRKRKRSSGTFCYCHPD 63

  Fly   108 SQNSLDESSQKHVQR----PNGKERGTVGQYSNEQHTARSFDAMNEMRKQKQLCDVILVADDVEI 168
            |:...||......||    |..|:..:..:|.   :.....:..|.        |:.:.|...|.
Mouse    64 SETDDDEDEGDEQQRLLNTPRRKKLKSTSKYI---YQTLFLNGENS--------DIKICALGEEW 117

  Fly   169 HAHRMVLASCSPYFYAMFT-SFEESRQARITL----QSVDARALELLIDYVYTATVEVNEDNVQV 228
            ..|::.|.. |.||.:||: |::||....|.|    |::|..||::....:|...|.:....|..
Mouse   118 SLHKIYLCQ-SGYFSSMFSGSWKESSMNIIELEIPDQNIDIEALQVAFGSLYRDDVLIKPSRVVA 181

  Fly   229 LLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADIHA-------CVE-LLNYAETYIEQHF 285
            :|.||.:|||..:...|.:.::..:......|....|..:.       |:| |||...|:
Mouse   182 ILAAACMLQLDGLIQQCGETMKETISVRTVCGYYTSAGTYGLDSVKKKCLEWLLNNLMTH----- 241

  Fly   286 NEVIQFDEFLNLSHEQVISLIGNDRISVPNEER-VYECVIAWL 327
             :.::.  |..||...:..|||:..:.|...|. ||..:..|:
Mouse   242 -QSVEL--FKELSINVMKQLIGSSNLFVMQVEMDVYTALKKWM 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	30/107 (28%)
		PHA03098	150..675	CDD:222983	48/192 (25%)
		BACK	258..359	CDD:285009	19/79 (24%)
		Kelch	405..449	CDD:128874
		KELCH repeat	439..482	CDD:276965
		Kelch	450..496	CDD:128874
		KELCH repeat	486..530	CDD:276965
		Kelch	497..543	CDD:128874
		KELCH repeat	533..580	CDD:276965
		Kelch	544..592	CDD:128874
		KELCH repeat	582..626	CDD:276965
		Kelch	594..639	CDD:128874
		KELCH repeat	629..674	CDD:276965
		Kelch	640..687	CDD:128874
Gmcl1	NP_035948.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		7/37 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	47..53		0/5 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..83		5/19 (26%)
		Nuclear localization signal. /evidence=ECO:0000255	83..89		2/5 (40%)
		BTB	96..203	CDD:279045	30/115 (26%)
		BTB	107..206	CDD:197585	29/99 (29%)
		BACK	211..>281	CDD:197943	18/77 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910