DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and KLHL18

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_005265058.2	Gene:	KLHL18 / 23276	HGNCID:	29120	Length:	584	Species:	Homo sapiens

Alignment Length:	578	Identity:	216/578 - (37%)
Similarity:	320/578 - (55%)	Gaps:	35/578 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 YSNEQHTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTS-FEESRQARI 197
            :|..:..:|.:..|.|:|:|.:||||.|...|.:..|||:|||:..|||:||||: ..|.:|..|
Human    15 FSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEI 79

  Fly   198 TLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIR 262
            .:|.:|..|||.||::.|...:.:::.|||.||..|:.|||..::||||.||:.:|...||||:|
Human    80 VMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVR 144

  Fly   263 EFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWL 327
            :||:...|..|.:.|.::|.|||.||...:|||.|..|.|:.|:..|.::|.:||:|:|..:||:
Human   145 QFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWV 209

  Fly   328 RYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYHLLP---TETK 389
            |||...|..:...|:.::|||....::::.||.::.|:.....|::|:.||..|||:|   ....
Human   210 RYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLP 274

  Fly   390 SARTVPRKPVGMPKILLVIGG-------QAPKAIRSVEWYDLREEKWYQAAEMPNRRCRSGLSVL 447
            :.||.||....:..::..:||       .|..::..||.:|.....|.:...|...|.|.|::|:
Human   275 AFRTRPRCCTSIAGLIYAVGGLNSAANFYAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVV 339

  Fly   448 GDKVYAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARRST-----LGVAVLNGCIYAVGGFDGT 507
            ...:||:||::|.||:.||:.|:|.||.|....:|.::||:     :|..||:|.||..||:||.
Human   340 NGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSSVCFSAMGTVVLDGQIYVCGGYDGN 404

  Fly   508 TGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDTW 572
            :.|||.|.|.|:||.|..:.|||:.||:.||.|..|.:|..||:||.  |..||||.||..|.||
Human   405 SSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL--QIFSSVEHYNHHTATW 467

  Fly   573 VNVAEMSSRRSGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETNSWRSVADMSYCRRNAGVVAH 637
            ...|.|.::|...|...|.:.::..||:||.......|.|....:.|..:..|...|....:||.
Human   468 HPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVAS 532

  Fly   638 DGLLYVVGGDDGTSNLASVEVYCPDSDSWRILPALMTIGRSYAGVCMIDKPMXMEEQG 695
            .|.||.|||.||.|||:|||:|.|::|.|..:                 .|| ..|.|
Human   533 CGRLYAVGGYDGQSNLSSVEMYDPETDCWTFM-----------------APMACHEGG 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	48/103 (47%)
		PHA03098	150..675	CDD:222983	208/540 (39%)
		BACK	258..359	CDD:285009	38/100 (38%)
		Kelch	405..449	CDD:128874	12/50 (24%)
		KELCH repeat	439..482	CDD:276965	18/42 (43%)
		Kelch	450..496	CDD:128874	20/50 (40%)
		KELCH repeat	486..530	CDD:276965	22/48 (46%)
		Kelch	497..543	CDD:128874	23/45 (51%)
		KELCH repeat	533..580	CDD:276965	23/46 (50%)
		Kelch	544..592	CDD:128874	20/47 (43%)
		KELCH repeat	582..626	CDD:276965	10/43 (23%)
		Kelch	594..639	CDD:128874	11/44 (25%)
		KELCH repeat	629..674	CDD:276965	21/44 (48%)
		Kelch	640..687	CDD:128874	17/46 (37%)
KLHL18	XP_005265058.2	BTB	28..131	CDD:279045	47/102 (46%)
		PHA03098	34..562	CDD:222983	206/529 (39%)
		BACK	140..242	CDD:285009	39/101 (39%)
		KELCH repeat	282..327	CDD:276965	7/44 (16%)
		Kelch	289..341	CDD:128874	12/51 (24%)
		Kelch_1	330..375	CDD:279660	18/44 (41%)
		KELCH repeat	331..374	CDD:276965	18/42 (43%)
		KELCH repeat	378..427	CDD:276965	22/48 (46%)
		Kelch	394..440	CDD:128874	23/45 (51%)
		KELCH repeat	430..474	CDD:276965	22/45 (49%)
		Kelch	441..486	CDD:128874	19/46 (41%)
		KELCH repeat	477..521	CDD:276965	10/43 (23%)
		Kelch_1	477..520	CDD:279660	10/42 (24%)
		Kelch_1	523..567	CDD:279660	21/60 (35%)
		KELCH repeat	524..567	CDD:276965	21/59 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820