DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and Klhl17

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_938047.1	Gene:	Klhl17 / 231003	MGIID:	2678948	Length:	640	Species:	Mus musculus

Alignment Length:	671	Identity:	283/671 - (42%)
Similarity:	390/671 - (58%)	Gaps:	69/671 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QQQGQNP----QQPAQNEGGAGAEFVAPPPGLGAAVGVAAMQQRNRLLQQQQQQHHHHQNPAAEG 94
            |.:|:.|    |.|..:..|.|.|  ||||                           .|.||.|.
Mouse     2 QPRGERPAGRTQSPEHSSPGPGPE--APPP---------------------------PQPPAPEA 37

  Fly    95 SGLERGSCLLRYASQNSLDESSQKHVQRPNGKERGTVGQYSNEQHTAR---------SFDAMNEM 150
                               |.::....||.....|.:...|.|.|:..         :|.||:.|
Mouse    38 -------------------ERARPRQARPAAPMEGAMQLLSREGHSVAHNSKRHYHDAFVAMSRM 83

  Fly   151 RKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTS-FEESRQARITLQSVDARALELLIDYV 214
            |::..|||::|.....||.||::|||||||||:||||: ..||||..:||..:|.:||:.|:.:.
Mouse    84 RQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFA 148

  Fly   215 YTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAET 279
            |||.:.|.|.|||.||.||:||||..||||||.||.:|||.|||||||.|||.|:|.:||..|..
Mouse   149 YTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDLLKAAHR 213

  Fly   280 YIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEH 344
            |:.|||.:|.:.:||:.|..:||:.|:.:|.::||:||.||..|::|:::||..|.|....||:.
Mouse   214 YVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDTRRQHVPRLMKC 278

  Fly   345 VRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYHLLPTE---TKSARTVPRKPVGMPKILL 406
            ||||.||::::...||.|.|:..:..||:|:||||.:||||.:   ..::||.||:..|...:|.
Mouse   279 VRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLF 343

  Fly   407 VIGGQAPKAIR-SVEWYDLREEKWYQAAEMPNRRCRSGLSVLGDKVYAVGGFNGSLRVRTVDVYD 470
            .:||.:..||. ..|.||.|.::|:..|.|..||.|.|::.:|:::|||||::|:..:.||:.||
Mouse   344 AVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYD 408

  Fly   471 PATDQWANCSNMEARRSTLGVAVLNGCIYAVGGFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSS 535
            |.|:.|....:|..|||.||||.|:|.:||.||:||.:.|:|||.|||.|..|..||:|||||..
Mouse   409 PVTNTWQPEVSMGTRRSCLGVAALHGLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRY 473

  Fly   536 VGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGH 600
            |.|..:.|.||||||||..:.  |::||:|.|..::|..||.|.||||.|||.||...||..||:
Mouse   474 VRVATLDGNLYAVGGYDSSSH--LATVEKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYVAGGN 536

  Fly   601 DGPMVRRSVEAYDCETNSWRSVADMSYCRRNAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDS 665
            ||.....|||.|..:..:|.|||.|:..|....:||.||.||.|||:||:|:|.|:|.|.|.::.
Mouse   537 DGTSCLNSVERYSTKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNK 601

  Fly   666 WRILPALMTIGRSYAGVCMID 686
            | :..:.|...||..||.:::
Mouse   602 W-VAASCMFTRRSSVGVAVLE 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	57/103 (55%)
		PHA03098	150..675	CDD:222983	253/529 (48%)
		BACK	258..359	CDD:285009	45/100 (45%)
		Kelch	405..449	CDD:128874	16/44 (36%)
		KELCH repeat	439..482	CDD:276965	17/42 (40%)
		Kelch	450..496	CDD:128874	22/45 (49%)
		KELCH repeat	486..530	CDD:276965	25/43 (58%)
		Kelch	497..543	CDD:128874	24/45 (53%)
		KELCH repeat	533..580	CDD:276965	21/46 (46%)
		Kelch	544..592	CDD:128874	26/47 (55%)
		KELCH repeat	582..626	CDD:276965	21/43 (49%)
		Kelch	594..639	CDD:128874	18/44 (41%)
		KELCH repeat	629..674	CDD:276965	19/44 (43%)
		Kelch	640..687	CDD:128874	19/47 (40%)
Klhl17	NP_938047.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		19/95 (20%)
		BTB_POZ_KLHL17_actinfilin	51..189	CDD:349555	66/137 (48%)
		PHA03098	90..556	CDD:222983	225/467 (48%)
		BACK	187..288	CDD:421692	49/100 (49%)
		Interaction with F-actin. /evidence=ECO:0000250	287..639		150/338 (44%)
		KELCH repeat	377..420	CDD:276965	17/42 (40%)
		KELCH repeat	424..468	CDD:276965	25/43 (58%)
		KELCH repeat	471..516	CDD:276965	21/46 (46%)
		KELCH repeat	518..562	CDD:276965	21/43 (49%)
		KELCH repeat	565..610	CDD:276965	20/45 (44%)
		Kelch	577..621	CDD:128874	19/44 (43%)
		Interaction with PDZK1. /evidence=ECO:0000250	638..640
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820