Protein Alignment kel and Klhl11

DIOPT Version :10

• Sequence 1: NP_476589.4
• Gene: kel / 35084
• FlyBaseID: FBgn0001301
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_766153.1
• Gene: Klhl11 / 217194
• MGIID: 2388648
• Length: 709
• Species: Mus musculus
• Alignment Length: 730
• Identity: 172/730 - (23%)
• Similarity: 290/730 - (39%)
• Gaps: 173/730 - (23%)

  Fly    61 LGAAVGVAAMQQRNRLLQQQQQQHHHHQNPAAEGSGL----ERGSCLLRY---ASQNSLDESSQK 118
            :.||...||.....::|:.:..:      .|..||..    .|||..:.:   |..::|.::
Mouse     5 VAAAAAAAAAAASFQVLEMESME------TAVAGSASLAAEVRGSGTVDFVTGAGISTLVDT--- 60

  Fly   119 HVQRPNGKERGTVGQ-YSNEQHTARSFDAMNEMRKQKQLCDVILV---ADDVEIHAHRMVLASCS 179
                 .|.:.|...: :....|.:......||.|:|...||:.|.   |...|..|||.|||:.:
Mouse    61 -----GGSDPGPEAEDFECSTHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAAT 120

  Fly   180 PYFYAMFT-SFEESRQARITLQSVDAR------ALELLIDYVYTATVEVNEDNVQVLLTAANLLQ 237
            .||..:.: .|.|||..|:.::...:.      .:|.:|:|:||..:.|:..:|..:|..|:...
Mouse   121 EYFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFL 185

  Fly   238 LTDVRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQV 302
            |..:::.|.:||:.:|..|||:.|...|.::...:|...|...|.::|.:|||.:||..|....:
Mouse   186 LIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFYKVIQDEEFYTLPFHLI 250

  Fly   303 ISLIGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEG 367
            ...:.:..|:|.:||.::|.|:.|::.:...||::...|.:.:||..:...|:|:.|..|.|:..
Mouse   251 RDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVAN 315

  Fly   368 NIVCKNLIIEALTYHLLPTE----------TKSARTVPRKPVGMPKILLVIGGQAPKAIRSVEWY 422
            |.||..|:.||:..|.|..|          |.....:||....| .:::|||
Mouse   316 NEVCVKLVAEAVERHALRAENIQSGTLQQPTSQVSLLPRYGQNM-DVIMVIG------------- 366

  Fly   423 DLREEKWYQAAEMPNRRCRSGLSVLGDKV-YAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARR 486
                                |:|..||.: ..||.|        ||     .|:|.|..::....
Mouse   367 --------------------GVSEGGDYLSECVGYF--------VD-----EDRWVNLPHIHNHL 398

  Fly   487 STLGVAVLNGCIYAVG----GFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYA 547
            ....||:....:|..|    ||..|     .|.|:|..:.|..:.|:.||:.|.|:..|.|.||:
Mouse   399 DGHAVAITESYVYVAGSMEPGFAKT-----VERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYS 458

  Fly   548 VGGYDGFTRQCLSSVERYNPDTDTWVNVAEMSSR--RSGAGVGVLNNILYAVG-------GHDGP 603
            :||:..|: .....|..|||:.|.|.|: |.:.:  |....:.:.:..:|...       ..||
Mouse   459 IGGHGNFS-PGFKDVTVYNPELDKWHNL-ESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDG- 520

  Fly   604 MVRRSVEAYDCETNSWRSVADM----SYC------------------------------RRNAGV 634
             ::..:..||.||..|:.|..:    :||                              |:.||.
Mouse   521 -LKAVITCYDTETRQWQDVESLPLIDNYCFFQMSVVNSNFYQTASCCPKSYSLENEEAVRKIAGQ 584

  Fly   635 VAHDGL---------------------LYVVGGDDGTSNL-----ASVEVYCPDSDSWRILPALM 673
            |:.:.|                     ::::||...:.::     .....||.:...|.:||. |
Mouse   585 VSDEILESLPPEVLSIEGAAICYYRDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPP-M 648

  Fly   674 TIGRSYAGVCMIDKP 688
            ...|..|..|.:..|
Mouse   649 PQPRCRATACHVRIP 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB_POZ_KLHL2-like	136..255	CDD:349544	37/128 (29%)
		PHA03098	150..675	CDD:222983	150/618 (24%)
		KELCH repeat	439..482	CDD:276965	12/43 (28%)
		KELCH repeat	486..530	CDD:276965	12/47 (26%)
		KELCH repeat	533..580	CDD:276965	17/46 (37%)
		KELCH repeat	582..626	CDD:276965	10/54 (19%)
		KELCH repeat	629..674	CDD:276965	12/70 (17%)
Klhl11	NP_766153.1	BTB_POZ_KLHL11	72..206	CDD:349550	38/133 (29%)
		PHA03098	91..554	CDD:222983	136/518 (26%)
		BACK_KLHL11	201..288	CDD:350526	25/86 (29%)
		Kelch 1	361..408		17/92 (18%)
		KELCH repeat	400..440	CDD:276965	11/44 (25%)
		Kelch 2	409..454		15/49 (31%)
		KELCH repeat	444..489	CDD:276965	17/46 (37%)
		Kelch 3	456..502		14/47 (30%)
		KELCH repeat	492..542	CDD:276965	10/51 (20%)
		Kelch 4	504..557		11/54 (20%)
		KELCH repeat	568..650	CDD:276965	13/82 (16%)
		Kelch 5	611..662		11/51 (22%)
		Kelch	612..658	CDD:128874	10/46 (22%)