DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and Klhl11

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_766153.1	Gene:	Klhl11 / 217194	MGIID:	2388648	Length:	709	Species:	Mus musculus

Alignment Length:	730	Identity:	172/730 - (23%)
Similarity:	290/730 - (39%)	Gaps:	173/730 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LGAAVGVAAMQQRNRLLQQQQQQHHHHQNPAAEGSGL----ERGSCLLRY---ASQNSLDESSQK 118
            :.||...||.....::|:.:..:      .|..||..    .|||..:.:   |..::|.::
Mouse     5 VAAAAAAAAAAASFQVLEMESME------TAVAGSASLAAEVRGSGTVDFVTGAGISTLVDT--- 60

  Fly   119 HVQRPNGKERGTVGQ-YSNEQHTARSFDAMNEMRKQKQLCDVILV---ADDVEIHAHRMVLASCS 179
                 .|.:.|...: :....|.:......||.|:|...||:.|.   |...|..|||.|||:.:
Mouse    61 -----GGSDPGPEAEDFECSTHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAAT 120

  Fly   180 PYFYAMFT-SFEESRQARITLQSVDAR------ALELLIDYVYTATVEVNEDNVQVLLTAANLLQ 237
            .||..:.: .|.|||..|:.::...:.      .:|.:|:|:||..:.|:..:|..:|..|:...
Mouse   121 EYFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFL 185

  Fly   238 LTDVRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQV 302
            |..:::.|.:||:.:|..|||:.|...|.::...:|...|...|.::|.:|||.:||..|....:
Mouse   186 LIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFYKVIQDEEFYTLPFHLI 250

  Fly   303 ISLIGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEG 367
            ...:.:..|:|.:||.::|.|:.|::.:...||::...|.:.:||..:...|:|:.|..|.|:..
Mouse   251 RDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVAN 315

  Fly   368 NIVCKNLIIEALTYHLLPTE----------TKSARTVPRKPVGMPKILLVIGGQAPKAIRSVEWY 422
            |.||..|:.||:..|.|..|          |.....:||....| .:::|||
Mouse   316 NEVCVKLVAEAVERHALRAENIQSGTLQQPTSQVSLLPRYGQNM-DVIMVIG------------- 366

  Fly   423 DLREEKWYQAAEMPNRRCRSGLSVLGDKV-YAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARR 486
                                |:|..||.: ..||.|        ||     .|:|.|..::....
Mouse   367 --------------------GVSEGGDYLSECVGYF--------VD-----EDRWVNLPHIHNHL 398

  Fly   487 STLGVAVLNGCIYAVG----GFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYA 547
            ....||:....:|..|    ||..|     .|.|:|..:.|..:.|:.||:.|.|:..|.|.||:
Mouse   399 DGHAVAITESYVYVAGSMEPGFAKT-----VERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYS 458

  Fly   548 VGGYDGFTRQCLSSVERYNPDTDTWVNVAEMSSR--RSGAGVGVLNNILYAVG-------GHDGP 603
            :||:..|: .....|..|||:.|.|.|: |.:.:  |....:.:.:..:|...       ..||
Mouse   459 IGGHGNFS-PGFKDVTVYNPELDKWHNL-ESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDG- 520

  Fly   604 MVRRSVEAYDCETNSWRSVADM----SYC------------------------------RRNAGV 634
             ::..:..||.||..|:.|..:    :||                              |:.||.
Mouse   521 -LKAVITCYDTETRQWQDVESLPLIDNYCFFQMSVVNSNFYQTASCCPKSYSLENEEAVRKIAGQ 584

  Fly   635 VAHDGL---------------------LYVVGGDDGTSNL-----ASVEVYCPDSDSWRILPALM 673
            |:.:.|                     ::::||...:.::     .....||.:...|.:||. |
Mouse   585 VSDEILESLPPEVLSIEGAAICYYRDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPP-M 648

  Fly   674 TIGRSYAGVCMIDKP 688
            ...|..|..|.:..|
Mouse   649 PQPRCRATACHVRIP 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	34/112 (30%)
		PHA03098	150..675	CDD:222983	150/618 (24%)
		BACK	258..359	CDD:285009	27/100 (27%)
		Kelch	405..449	CDD:128874	5/43 (12%)
		KELCH repeat	439..482	CDD:276965	12/43 (28%)
		Kelch	450..496	CDD:128874	10/46 (22%)
		KELCH repeat	486..530	CDD:276965	12/47 (26%)
		Kelch	497..543	CDD:128874	15/49 (31%)
		KELCH repeat	533..580	CDD:276965	17/46 (37%)
		Kelch	544..592	CDD:128874	14/49 (29%)
		KELCH repeat	582..626	CDD:276965	10/54 (19%)
		Kelch	594..639	CDD:128874	15/85 (18%)
		KELCH repeat	629..674	CDD:276965	12/70 (17%)
		Kelch	640..687	CDD:128874	12/72 (17%)
Klhl11	NP_766153.1	BTB	86..198	CDD:279045	34/111 (31%)
		BTB	96..201	CDD:197585	30/104 (29%)
		BACK	206..308	CDD:285009	27/101 (27%)
		Kelch 1	361..408		17/92 (18%)
		KELCH repeat	400..440	CDD:276965	11/44 (25%)
		Kelch 2	409..454		15/49 (31%)
		Kelch_1	443..487	CDD:279660	17/45 (38%)
		KELCH repeat	444..489	CDD:276965	17/46 (37%)
		Kelch 3	456..502		14/47 (30%)
		KELCH repeat	492..542	CDD:276965	10/51 (20%)
		Kelch 4	504..557		11/54 (20%)
		KELCH repeat	568..650	CDD:276965	13/82 (16%)
		Kelch 5	611..662		11/51 (22%)
		Kelch	612..658	CDD:128874	10/46 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910