DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kel and kel-1

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001254310.1	Gene:	kel-1 / 174791	WormBaseID:	WBGene00002184	Length:	618	Species:	Caenorhabditis elegans

Alignment Length:	605	Identity:	258/605 - (42%)
Similarity:	366/605 - (60%)	Gaps:	39/605 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 SQKHVQRPNGKERGTVGQYSNEQHTARSFDAMNEMRKQKQLCDVIL-------------VADDV- 166
            |..:.:.||..:...   |||.......:..:|.||.|::||||:|             ::|||
Worm    18 SHSNSRSPNFNKTSI---YSNPTMLGEFYQNLNLMRCQQELCDVVLEAYPIQGTSSEDGMSDDVH 79

  Fly   167 -EIHAHRMVLASCSPYFYAMFT-SFEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVL 229
             .|||||::|::.|.||.|||| ...||.|..|.::.||...|..||||:||..:.::|.|||.:
Worm    80 QHIHAHRVILSASSSYFRAMFTGGLRESTQRIIPIKEVDVEVLSQLIDYMYTGRMRIDEQNVQTI 144

  Fly   230 LTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEF 294
            |..|:|||||.|||||..|:...||.:||:|:.|||..|||.:|.:.|:.|..|||.|:|..:|.
Worm   145 LATASLLQLTCVRDACARFMLELLDMTNCVGMAEFARAHACHQLAHAAQLYTRQHFVEIIDNEEL 209

  Fly   295 LNLSHEQVISLIGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRV 359
            |:|..:....||.:|||:||:|:.|.:.|:.|:.::.|.|..|.:.||.:||||.|..:|:.::.
Worm   210 LSLDKDAFCELIQDDRITVPSEKPVMQAVLNWVAHEEPSRRPFLAELMSNVRLPLLGDDYLFEKW 274

  Fly   360 DKEILLEGNIVCKNLIIEALTYHLLPTETKSARTVPRKPV------------GMPKI--LLVIGG 410
            ..:.:::.:..|.|:|||.: :.|..|:...:.|.|..|:            .||:.  ::::||
Worm   275 RNDEMIKSDAACLNVIIEGM-HQLKITKQDISSTEPHYPIQELNRKWFVAREPMPESQHIMIVGG 338

  Fly   411 QAPKAIRSVEWYDLREEKWYQAAEMPNRRCRSGLSVLGDKVYAVGGFNGSLRVRTVDVYDPATDQ 475
            ||||||.:|:.:|...:.|...|.:|.||||||:|:....||..|||||:.|||:||.|||.||.
Worm   339 QAPKAITNVDLFDPDSQLWSSCASLPQRRCRSGVSMCNGYVYTTGGFNGAQRVRSVDFYDPRTDT 403

  Fly   476 WANCSNMEARRSTLGVAVLNGCIYAVGGFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGV 540
            |.:.:.|.|||||.|:......:||||||||||||:|||.:||.|..|..:.|||||||||||..
Worm   404 WRSANQMSARRSTHGITTCQQVLYAVGGFDGTTGLASAEYFDPHTGNWFPLPSMSTRRSSVGVAA 468

  Fly   541 VHGLLYAVGGYDGFTRQCLSSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGPMV 605
            ....:||:||:||.::|||::||.::.....|.....|.:.||||||.|.:..:.|||||.|..:
Worm   469 FEEDIYAIGGFDGVSKQCLNTVEIFDRRAHKWRPGPAMLNVRSGAGVTVYDKKIIAVGGHKGAEI 533

  Fly   606 RRSVEAYDCETNSWRSVADMSYCRRNAGVVAHDGLLYVVGGDDGTSNLASVE-VYCPD-SDS-WR 667
            .||.|....|  .|..:|:|:..|||....|.:||||.||||||:|||:::| :...| ||: |:
Worm   534 HRSAEILIGE--EWIELANMAIPRRNTAATALNGLLYAVGGDDGSSNLSTIECIQLSDRSDAQWK 596

  Fly   668 ILPALMTIGRSYAGVCMIDK 687
            |:.|.|:.||||||:.:|.|
Worm   597 IVDAPMSQGRSYAGIALIPK 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	55/118 (47%)
		PHA03098	150..675	CDD:222983	243/557 (44%)
		BACK	258..359	CDD:285009	41/100 (41%)
		Kelch	405..449	CDD:128874	20/43 (47%)
		KELCH repeat	439..482	CDD:276965	24/42 (57%)
		Kelch	450..496	CDD:128874	25/45 (56%)
		KELCH repeat	486..530	CDD:276965	24/43 (56%)
		Kelch	497..543	CDD:128874	30/45 (67%)
		KELCH repeat	533..580	CDD:276965	19/46 (41%)
		Kelch	544..592	CDD:128874	20/47 (43%)
		KELCH repeat	582..626	CDD:276965	19/43 (44%)
		Kelch	594..639	CDD:128874	17/44 (39%)
		KELCH repeat	629..674	CDD:276965	24/47 (51%)
		Kelch	640..687	CDD:128874	27/49 (55%)
kel-1	NP_001254310.1	PHA03098	82..603	CDD:222983	231/523 (44%)
		KELCH repeat	367..410	CDD:276965	24/42 (57%)
		KELCH repeat	414..458	CDD:276965	24/43 (56%)
		KELCH repeat	461..507	CDD:276965	18/45 (40%)
		KELCH repeat	510..552	CDD:276965	19/43 (44%)
		KELCH repeat	555..604	CDD:276965	25/48 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164194
Domainoid	1	1.000	97	1.000	Domainoid score	I4542
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H79542
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	1	1.000	-	-		oto18986
orthoMCL	1	0.900	-	-		OOG6_100281
Panther	1	1.100	-	-	LDO	PTHR24412
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4618
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.870