DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and kel-20

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_491322.2	Gene:	kel-20 / 172012	WormBaseID:	WBGene00020030	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	570	Identity:	219/570 - (38%)
Similarity:	328/570 - (57%)	Gaps:	22/570 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LDESSQKHVQRPNGKERGTVGQYSNEQHTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLA 176
            :|..|..|......:.|....:|.|..........:..::.:..||||.|:.....|:|||:||:
Worm    11 MDLPSTSHDSADMFESRKPQSKYKNSHFANSVLQQLGGLKNRDVLCDVTLICGWKRINAHRVVLS 75

  Fly   177 SCSPYFYAMFTS-FEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTD 240
            :|||||.:|||| ..|.....|.::.::...||.||::.||..:.:::.|||.:|.||.|||:.:
Worm    76 ACSPYFLSMFTSQMAECYMREINMEEIEPPTLEALIEFCYTGAIAIDDSNVQDILPAACLLQIHE 140

  Fly   241 VRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISL 305
            |:.||||:|:.|||.|||||||.|||.|:|.|||:.|:.:..::|:.||..:||..|:.|.:.::
Worm   141 VQTACCDYLKKQLDPSNCLGIRAFADTHSCKELLSSADEFALKNFSRVIGKEEFQMLTVESLTTI 205

  Fly   306 IGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIV 370
            |.:|:::..:||.|:..||.|:|:|:..|:...|:|:.|||||..:.:::...|.:|||::.:..
Worm   206 IKSDKLNAASEELVFSAVIQWVRHDISKRKTHLSMLLSHVRLPLCTPKFLVSVVSEEILVKSDPA 270

  Fly   371 CKNLIIEALTYHLLPTE---TKSARTVPRKPVGMPKILLVIGGQ-APKAIRSVEWYDLRE--EKW 429
            .::|:.||..|.|||.|   .:..||.||||:...::|..:||. :..||.|:|..|..:  ..|
Worm   271 SRDLVDEAKNYLLLPVERPNMQGPRTKPRKPLQGSEVLYAVGGWCSGDAIASIERLDPMKGGTTW 335

  Fly   430 YQAAEMPNRRCRSGLSVLGDKVYAVGGFNGSLRVRTVDVYDPATDQW-------ANCSNMEARRS 487
            ...|.|..|||..|::||.:.:|||||.:|...:.:::.|||.|:||       |.|      |:
Worm   336 KCVAPMGKRRCGVGVAVLENLLYAVGGHDGQSYLNSIERYDPMTNQWSSDVAPTATC------RT 394

  Fly   488 TLGVAVLNGCIYAVGGFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYD 552
            ::|||..||.:|||||.||.:.|...|.|||:.:.|..:|||.|||..|.|.||:|.:|||||.:
Worm   395 SVGVAAFNGSLYAVGGQDGESCLDVVEKYDPRKNEWAKVASMGTRRLGVSVSVVNGCIYAVGGSN 459

  Fly   553 GFTRQCLSSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETN 617
            |  ...|::||||:|....|..|..|.::|...|..|.:..:|||||.|......:.|.|..|.:
Worm   460 G--PAPLNTVERYDPRVGKWEEVRPMLTKRKHLGTAVYDGYIYAVGGRDTTTELNTAERYSVERD 522

  Fly   618 SWRSVADMSYCRRNAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSWR 667
            .|:.|..||..|...||......||.|||.||.:.|.|||::..|::.|:
Worm   523 EWQPVVAMSNRRSGVGVAVVGEKLYAVGGFDGQTYLKSVEIFDKDTNRWK 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	42/103 (41%)
		PHA03098	150..675	CDD:222983	213/532 (40%)
		BACK	258..359	CDD:285009	39/100 (39%)
		Kelch	405..449	CDD:128874	17/46 (37%)
		KELCH repeat	439..482	CDD:276965	19/49 (39%)
		Kelch	450..496	CDD:128874	18/52 (35%)
		KELCH repeat	486..530	CDD:276965	21/43 (49%)
		Kelch	497..543	CDD:128874	23/45 (51%)
		KELCH repeat	533..580	CDD:276965	21/46 (46%)
		Kelch	544..592	CDD:128874	18/47 (38%)
		KELCH repeat	582..626	CDD:276965	14/43 (33%)
		Kelch	594..639	CDD:128874	16/44 (36%)
		KELCH repeat	629..674	CDD:276965	16/39 (41%)
		Kelch	640..687	CDD:128874	13/28 (46%)
kel-20	NP_491322.2	PHA03098	56..572	CDD:222983	211/523 (40%)
		KELCH repeat	345..389	CDD:276965	17/43 (40%)
		KELCH repeat	393..437	CDD:276965	21/43 (49%)
		KELCH repeat	440..485	CDD:276965	21/46 (46%)
		KELCH repeat	487..531	CDD:276965	14/43 (33%)
		KELCH repeat	534..577	CDD:276965	16/39 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820