DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and KLHL40

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_689606.2	Gene:	KLHL40 / 131377	HGNCID:	30372	Length:	621	Species:	Homo sapiens

Alignment Length:	603	Identity:	147/603 - (24%)
Similarity:	228/603 - (37%)	Gaps:	167/603 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 DAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTSFEESRQARITLQSVDARALEL 209
            |.:.:|....:..|.::.|.:.|...||:|||:|||||.|.|.: |..|...:.|:.|....:..
Human    21 DGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLA-EPERAGELHLEEVSPDVVAQ 84

  Fly   210 LIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADIHACVELL 274
            ::.|:||:.:.::|.:||.|..||:..|:..:...|..|||.:|..||||.:.....:..|..|.
Human    85 VLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARLA 149

  Fly   275 NYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWL-RYDVPM---RE 335
            ..|..:|..||..|.:..:||.||.:::|::|.:|.::|..||.|:|.|:.|. ..|...   |:
Human   150 VAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAEAQAERQ 214

  Fly   336 QFTSLLMEHVRLPFLSKEYITQRVDKEILL-----------------EGNIV------------- 370
            :....:.|.||...|.:.::..||::..|:                 ||.|.
Human   215 RALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDAHEGRITTLRKKKKGKDGAG 279

  Fly   371 ------------------------------------CKNLII-----EALTYHLLPTETKSA--- 391
                                                .::||.     .|:.|.....|...|
Human   280 AKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLS 344

  Fly   392 RTVPRKPV-----------------------------------------GMPKI----------- 404
            ..||:..|                                         |||.:
Human   345 NQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGE 409

  Fly   405 ----LLVIGGQ----APKAIRSVEWYDLREEKWYQAAEMPNRRCRSGLSVLG--DKVYAVGGFNG 459
                :.|:||:    ..:.:.||..||....||.::..:|  ....|.:||.  |.||.:|| .|
Human   410 ALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGESDPLP--YVVYGHTVLSHMDLVYVIGG-KG 471

  Fly   460 SLR--VRTVDVYDPATDQWANCSNMEARRSTLGVAVLNGCIYAVGGFDGTTGLSSAEMYDPKTDI 522
            |.|  :..:.||||...:|...:.|:..||..|..|.:|.|....|...|...||||:|....:.
Human   472 SDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNK 536

  Fly   523 WRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQC-------LSSVERYNPDTDTWVNVAEMSS 580
            |....:....|||:.:..:.|.|||:||:.....:.       |:.:.|||.:...|
Human   537 WAPFEAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKW-------- 593

  Fly   581 RRSGAGVGVLNNILYAVG 598
                  .|||..|.||.|
Human   594 ------EGVLREIAYAAG 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	32/102 (31%)
		PHA03098	150..675	CDD:222983	146/598 (24%)
		BACK	258..359	CDD:285009	29/104 (28%)
		Kelch	405..449	CDD:128874	13/49 (27%)
		KELCH repeat	439..482	CDD:276965	16/46 (35%)
		Kelch	450..496	CDD:128874	17/47 (36%)
		KELCH repeat	486..530	CDD:276965	14/43 (33%)
		Kelch	497..543	CDD:128874	12/45 (27%)
		KELCH repeat	533..580	CDD:276965	14/53 (26%)
		Kelch	544..592	CDD:128874	13/54 (24%)
		KELCH repeat	582..626	CDD:276965	7/17 (41%)
		Kelch	594..639	CDD:128874	3/5 (60%)
		KELCH repeat	629..674	CDD:276965
		Kelch	640..687	CDD:128874
KLHL40	NP_689606.2	BTB	23..125	CDD:279045	32/102 (31%)
		PHA03098	47..551	CDD:222983	124/507 (24%)
		BACK	133..239	CDD:285009	30/105 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..295		1/29 (3%)
		KELCH repeat	351..398	CDD:276965	4/46 (9%)
		Kelch 1	360..412		3/51 (6%)
		Kelch_1	401..442	CDD:279660	7/40 (18%)
		KELCH repeat	402..448	CDD:276965	9/45 (20%)
		Kelch 2	413..462		13/50 (26%)
		KELCH repeat	452..497	CDD:276965	16/45 (36%)
		Kelch	463..510	CDD:128874	17/47 (36%)
		Kelch 3	463..510		17/47 (36%)
		Kelch_1	499..537	CDD:279660	13/37 (35%)
		Kelch 4	512..557		12/44 (27%)
		Kelch_1	547..594	CDD:279660	14/60 (23%)
		KELCH repeat	547..594	CDD:276965	14/60 (23%)
		Kelch 5	559..613		17/61 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810