DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and KLHL2

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_011529874.1	Gene:	KLHL2 / 11275	HGNCID:	6353	Length:	633	Species:	Homo sapiens

Alignment Length:	648	Identity:	356/648 - (54%)
Similarity:	454/648 - (70%)	Gaps:	74/648 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 HQNPAAEGSGLERGSCLLRYASQNSLDESSQKHVQRPNGKERGTVGQYSNEQHTARSFDAMNEMR 151
            ||.|.                  :|.|::::||..       .||    |..|..::|..|||:|
Human    15 HQKPL------------------DSKDDNTEKHCP-------VTV----NPWHMKKAFKVMNELR 50

  Fly   152 KQKQ----------------------------------------LCDVILVADDVEIHAHRMVLA 176
            :|..                                        ||||.:||:|:||.|||:|||
Human    51 RQSHSATQAGMQWRDLSSLQPPTPGFKRLSHLSLPSSWDYSQNLLCDVTIVAEDMEISAHRVVLA 115

  Fly   177 SCSPYFYAMFT-SFEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTD 240
            :|||||:|||| ...|||..|:.::.||...|.:||||||||.::|.|:||||||.||.||||.|
Human   116 ACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQD 180

  Fly   241 VRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISL 305
            |:..||:||::||...||||||.|||:|||.:|||.|.||.||||.:|:..:|||||..|||.||
Human   181 VKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSL 245

  Fly   306 IGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIV 370
            |.:|::::.:||:|:|.||||:.:|..:|::|.:.||||||||.|.:||:.|||::|.|::.:..
Human   246 ISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 310

  Fly   371 CKNLIIEALTYHLLPTE----TKSARTVPRKPVGMPKILLVIGGQAPKAIRSVEWYDLREEKWYQ 431
            ||:.:|||:.|||||||    .||.||..|.|:.:||:::|:||||||||||||.||.:||:|:|
Human   311 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQ 375

  Fly   432 AAEMPNRRCRSGLSVLGDKVYAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARRSTLGVAVLNG 496
            .||:|:||||:|:..:...|:|||||||||||||||.|||..|||.:.:||..||||||.|||||
Human   376 VAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNG 440

  Fly   497 CIYAVGGFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSS 561
            .:||||||||:|||||.|.|:.|::.|..:|.|:|||||||||||.|||||||||||.:|||||:
Human   441 LLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLST 505

  Fly   562 VERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETNSWRSVADMS 626
            ||.||..|:.|..:||||:||||||||||||:||||||||||:||:|||.||..||:||.||||:
Human   506 VECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMN 570

  Fly   627 YCRRNAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSWRILPALMTIGRSYAGVCMIDKPM 689
            .|||||||.|.:|||||||||||:.||||||.|.|.:|.|.::.:.|:.|||||||.:||||:
Human   571 MCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	63/143 (44%)
		PHA03098	150..675	CDD:222983	330/569 (58%)
		BACK	258..359	CDD:285009	57/100 (57%)
		Kelch	405..449	CDD:128874	27/43 (63%)
		KELCH repeat	439..482	CDD:276965	26/42 (62%)
		Kelch	450..496	CDD:128874	33/45 (73%)
		KELCH repeat	486..530	CDD:276965	28/43 (65%)
		Kelch	497..543	CDD:128874	30/45 (67%)
		KELCH repeat	533..580	CDD:276965	34/46 (74%)
		Kelch	544..592	CDD:128874	35/47 (74%)
		KELCH repeat	582..626	CDD:276965	35/43 (81%)
		Kelch	594..639	CDD:128874	33/44 (75%)
		KELCH repeat	629..674	CDD:276965	28/44 (64%)
		Kelch	640..687	CDD:128874	29/46 (63%)
KLHL2	XP_011529874.1	GVQW	57..>90	CDD:290611	0/32 (0%)
		PHA03098	89..613	CDD:222983	327/523 (63%)
		BTB	90..189	CDD:279045	57/98 (58%)
		BACK	198..300	CDD:285009	58/101 (57%)
		Kelch	351..393	CDD:128874	27/41 (66%)
		KELCH repeat	383..426	CDD:276965	26/42 (62%)
		Kelch	394..440	CDD:128874	33/45 (73%)
		Kelch_1	429..474	CDD:279660	29/44 (66%)
		KELCH repeat	430..474	CDD:276965	28/43 (65%)
		Kelch	488..536	CDD:128874	35/47 (74%)
		KELCH repeat	526..570	CDD:276965	35/43 (81%)
		Kelch	537..583	CDD:128874	33/45 (73%)
		KELCH repeat	573..619	CDD:276965	29/45 (64%)
		Kelch	584..631	CDD:128874	29/46 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4855
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	1	1.000	-	-		otm41829
orthoMCL	1	0.900	-	-		OOG6_100281
Panther	1	1.100	-	-	LDO	PTHR24412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.770