DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kel and klhl17

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_004916201.1	Gene:	klhl17 / 100491332	XenbaseID:	XB-GENE-977875	Length:	627	Species:	Xenopus tropicalis

Alignment Length:	618	Identity:	279/618 - (45%)
Similarity:	385/618 - (62%)	Gaps:	36/618 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LLQQQQ--QQHHHHQNPAAEGSGLERGSCLLRYASQNSLDESSQKHVQRPNGKERGTVGQYSNEQ 138
            |||:.:  ::....|:||.|      |:..|.....:|:..:|::|                  .
Frog    20 LLQRVKPVKEKSGDQSPAME------GAVQLLTRDGHSISHNSKRH------------------Y 60

  Fly   139 HTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTS-FEESRQARITLQSV 202
            |.|  |..||.||::..|||::|.....||..|::|||||||||:||||: ..||||..:||..:
Frog    61 HDA--FVCMNRMRQRGLLCDIVLHVGTKEIKGHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDI 123

  Fly   203 DARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADI 267
            |.:|||.|:.|.|||.:.|.|.|||.||.||:||||..||||||.||.:|||.|||||||.|||.
Frog   124 DPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADT 188

  Fly   268 HACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWLRYDVP 332
            |:|.:||..|..|:.|||.||.:.:||:.|..:||:.||.:|.::||:||.||..|:.|:::||.
Frog   189 HSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLNWVKHDVD 253

  Fly   333 MREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYHLLPTE---TKSARTV 394
            .|.|....||:.||||.||::::...||.|:|:..:..||:|:||||.|||:|.:   ..::||.
Frog   254 GRRQHVPRLMKCVRLPLLSRDFLMSSVDTELLVRHHSECKDLLIEALKYHLMPEQRGVLSNSRTR 318

  Fly   395 PRKPVGMPKILLVIGGQAPKAIR-SVEWYDLREEKWYQAAEMPNRRCRSGLSVLGDKVYAVGGFN 458
            ||:..|...:|..:||.:..||. ..|.||.|.::|:....|..||.|.|::.:|:|:|||||::
Frog   319 PRRCEGASTVLFAVGGGSLFAIHGDCEAYDTRTDRWHMVTSMSTRRARVGVAAIGNKLYAVGGYD 383

  Fly   459 GSLRVRTVDVYDPATDQWANCSNMEARRSTLGVAVLNGCIYAVGGFDGTTGLSSAEMYDPKTDIW 523
            |:..:.||:.|||.|:.|....:|..|||.||||||:|.:||.||:||.:.|:|||.|||.|..|
Frog   384 GTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAVLHGLLYAAGGYDGASCLNSAERYDPLTGTW 448

  Fly   524 RFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDTWVNVAEMSSRRSGAGVG 588
            ..||:|||||..|.|..:.|.||||||||..:.  |::||:|.|..:||..:|.|.||||.|||.
Frog   449 TSIAAMSTRRRYVRVATLDGNLYAVGGYDSSSH--LATVEKYEPQINTWTPIANMLSRRSSAGVA 511

  Fly   589 VLNNILYAVGGHDGPMVRRSVEAYDCETNSWRSVADMSYCRRNAGVVAHDGLLYVVGGDDGTSNL 653
            ||..:||..||:||.....|||.|:.:.|:|.|||.|:..|....:||.||.||.|||:||:|:|
Frog   512 VLEGMLYVAGGNDGTSCLNSVERYNPKANTWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSL 576

  Fly   654 ASVEVYCPDSDSWRILPALMTIGRSYAGVCMID 686
            .|:|.|.|.::.| :..:.|...||..||.:::
Frog   577 NSIEKYNPRTNKW-VAASCMFTRRSSVGVAVLE 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	59/103 (57%)
		PHA03098	150..675	CDD:222983	258/529 (49%)
		BACK	258..359	CDD:285009	47/100 (47%)
		Kelch	405..449	CDD:128874	15/44 (34%)
		KELCH repeat	439..482	CDD:276965	18/42 (43%)
		Kelch	450..496	CDD:128874	24/45 (53%)
		KELCH repeat	486..530	CDD:276965	26/43 (60%)
		Kelch	497..543	CDD:128874	24/45 (53%)
		KELCH repeat	533..580	CDD:276965	21/46 (46%)
		Kelch	544..592	CDD:128874	26/47 (55%)
		KELCH repeat	582..626	CDD:276965	22/43 (51%)
		Kelch	594..639	CDD:128874	19/44 (43%)
		KELCH repeat	629..674	CDD:276965	19/44 (43%)
		Kelch	640..687	CDD:128874	19/47 (40%)
klhl17	XP_004916201.1	BTB_POZ_KLHL17_actinfilin	38..176	CDD:349555	71/163 (44%)
		PHA03098	77..543	CDD:222983	230/467 (49%)
		KELCH repeat	321..360	CDD:276965	11/38 (29%)
		KELCH repeat	364..407	CDD:276965	18/42 (43%)
		KELCH repeat	411..454	CDD:276965	26/42 (62%)
		KELCH repeat	458..502	CDD:276965	20/45 (44%)
		KELCH repeat	505..549	CDD:276965	22/43 (51%)
		KELCH repeat	552..597	CDD:276965	20/45 (44%)
		Kelch	564..608	CDD:128874	19/44 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010