DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and klhl12

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001106569.1	Gene:	klhl12 / 100127776	XenbaseID:	XB-GENE-961995	Length:	320	Species:	Xenopus tropicalis

Alignment Length:	298	Identity:	132/298 - (44%)
Similarity:	192/298 - (64%)	Gaps:	10/298 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 HTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTS-FEESRQARITLQSV 202
            |.....:.||.:||.:.||||.|..:..:..|||:|||:||.||.||||: ..|..:..:.:|.:
Frog    11 HAKSILNTMNSLRKSQTLCDVTLRVNLKDFPAHRIVLAACSDYFCAMFTNELSEKGKPYVDIQGL 75

  Fly   203 DARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADI 267
            .:..:|:|:|:|||.||.|..:|||.||.||.||||..|:.||||||::|||.|||||||:||:.
Frog    76 TSSTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCDFLESQLDPSNCLGIRDFAET 140

  Fly   268 HACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWLRYDVP 332
            |.|::|:..||.|.::||.||:|.:||:.|..|:|..||..|.|.:.:||.|:|.||.|::::..
Frog   141 HNCLDLMQAAEVYSQKHFPEVVQHEEFMLLHQEEVEKLIHCDEIQINSEEPVFEAVINWVKHNKN 205

  Fly   333 MREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYHLLPTETKSARTVPRK 397
            .||:....|:::||:|.|:..|||..:|.|.|:..::.|::|:.||..:||.| |.:|....||.
Frog   206 EREKSLPQLLQYVRMPLLTPRYITDVIDAEPLIRCSLQCRDLVDEAKKFHLRP-ELRSQMQGPRT 269

  Fly   398 PV--GMPKILLVIGG----QAPKAIRSVEWYDLREEKW 429
            .|  |..::||||||    |:|  |..||.||.:.::|
Frog   270 RVRLGANEVLLVIGGFGSQQSP--IDIVEKYDPKTQEW 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	51/103 (50%)
		PHA03098	150..675	CDD:222983	129/287 (45%)
		BACK	258..359	CDD:285009	44/100 (44%)
		Kelch	405..449	CDD:128874	14/29 (48%)
		KELCH repeat	439..482	CDD:276965
		Kelch	450..496	CDD:128874
		KELCH repeat	486..530	CDD:276965
		Kelch	497..543	CDD:128874
		KELCH repeat	533..580	CDD:276965
		Kelch	544..592	CDD:128874
		KELCH repeat	582..626	CDD:276965
		Kelch	594..639	CDD:128874
		KELCH repeat	629..674	CDD:276965
		Kelch	640..687	CDD:128874
klhl12	NP_001106569.1	Kelch_1	267..309	CDD:279660	18/41 (44%)
		KELCH repeat	268..309	CDD:276965	17/40 (43%)
		BTB	19..122	CDD:279045	50/102 (49%)
		BTB	30..126	CDD:197585	46/95 (48%)
		BACK	131..232	CDD:285009	44/100 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010