DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5758 and YLR001C

DIOPT Version :9

Sequence 1:	NP_001286028.1	Gene:	CG5758 / 35083	FlyBaseID:	FBgn0032666	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_013101.1	Gene:	YLR001C / 850687	SGDID:	S000003991	Length:	862	Species:	Saccharomyces cerevisiae

Alignment Length:	559	Identity:	112/559 - (20%)
Similarity:	195/559 - (34%)	Gaps:	198/559 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 QVYRFIDDGFPVLELYG---YKPLPDLPYTLIVPKID--------VRSIEKP-------RLKEFM 126
            |..::|....|:|.|..   ..|..|.|::.::..:.        :|.|:|.       .|:.|.
Yeast     6 QTIKYIFWLLPILGLTQALLQNPGDDFPFSTVIDILSENVEFSTFLRIIQKTGHVQYLNELQNFT 70

  Fly   127 LEHVVPGKIFDSYN-----GNGNSKEEEESFGNGNGHKIVFRKLEKSHNNVWLLNGQQILHKLRI 186
            |        |...|     |:..:.:.||.|                |...:|::.:.:  ::|.
Yeast    71 L--------FAPINSAFIKGDQTTDQFEEHF----------------HIEDFLIHDRVL--QVRD 109

  Fly   187 NENLMAIAIDGYLGDR--KSPYSKRNIQETNNRYNDPQPLEQ---PNITNAHAK-------VEPV 239
            .||      ..||..|  |:|...|. .|.:...|:...:|.   |:..||..:       ::|.
Yeast   110 LEN------GTYLEKRAAKAPLLLRK-HERHCFVNEIAVVEPDLLPSFQNASLQGINNLLLIQPQ 167

  Fly   240 IKESKASPLMSFLANMKTGTKVFQHFLSK-SNLTRIMDDNAY----TVLIPSDNAFQRWHPIDWG 299
            |.|     |:..|.......|:|..|:|. ||.      |||    |||:|.|..|::
Yeast   168 INE-----LLVQLDEETQDLKIFSDFISSFSNY------NAYTNSSTVLVPLDVNFRK------- 214

  Fly   300 FYPFSVPEFTESVLRNHFLPMQRPLRLADVRN-----------MDEVVVTTMGG----EDVVFHG 349
                    |..::..|:.|.....|..::..:           :.|:::..:.|    ::::...
Yeast   215 --------FFNTIEINYLLDKYNKLGKSNTISQAKWAADRTSLLQELIIDDVYGGILPKELILEN 271

  Fly   350 Q-------------PTPTVNNVSIMSDYNLSNGNQVFIISEVLFVTEAVVSKLHQMHKDKETPPL 401
            :             .:.:|||    |||: ...|::|.|..|              |...:...|
Yeast   272 KNNRKLFMKSNSEGTSVSVNN----SDYS-PISNRIFEIGVV--------------HGFSDLDFL 317

  Fly   402 LAFPWFGAQFLSHSFLALE--RDPRFTQITRYLNSAEIAPHISGANYTFFVPEDRAFEKQGFDKL 464
            .....|.|:...|.....|  ::..|..:.:::.        :|...|.|||:....|.:|:.|.
Yeast   318 RTHIQFDAEKYLHGLNCSEFVKELYFRDLEKFIQ--------NGRKITIFVPQASFNEDRGYTKP 374

  Fly   465 SDEVMASQRGVKMLLNHFVKGRLYNRDLRDN------------EVFETIG-------GGH---IK 507
            |            ||.|||:|::   ||..:            :::::..       |||   .|
Yeast   375 S------------LLYHFVEGKI---DLEQDFSSLRPIQYAPTQIYDSAFCSSAKRLGGHCQKFK 424

  Fly   508 ITRNPGSNYTSVNNAQITESEVFVYNLG--TMYYLDDIL 544
            |||:....|.   |.:........|.:|  ::|.:||.|
Yeast   425 ITRSNKGYYI---NGRFKILNTKPYEIGNTSIYSIDDDL 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5758	NP_001286028.1	FAS1	281..380	CDD:214719	22/126 (17%)
CG5758	NP_001286028.1	FAS1	447..545	CDD:214719	31/122 (25%)
YLR001C	NP_013101.1	Fasciclin	<36..>86	CDD:413430	9/57 (16%)
		Fasciclin	78..468	CDD:413430	96/479 (20%)
		Fasciclin	493..603	CDD:413430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344696
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10900
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030