DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5758 and Tgfbi

DIOPT Version :9

Sequence 1:	NP_001286028.1	Gene:	CG5758 / 35083	FlyBaseID:	FBgn0032666	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_446254.1	Gene:	Tgfbi / 116487	RGDID:	620017	Length:	685	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	118/577 - (20%)
Similarity:	217/577 - (37%)	Gaps:	127/577 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VLLSLLPIAHVAAASATAADATAATAASTTSTGIDASLKNAKLIEAKVLPDLAILQRVNQEDEKW 78
            :|:.|||:|...:...|      .|.|....:.....|::::|...:..|::..:|:|...::|:
  Rat     3 LLVRLLPLALALSLGFT------GTLAGPAKSPYQLVLQHSRLRGRQHGPNVCAVQKVIGTNKKY 61

  Fly    79 ----QQVYRFIDDGFPVLELY----GYKPLPD-------LPYTLIVPKIDVRSIEKPRLKEFMLE 128
                :|.|:....|...:..|    ||:.:|.       ||.:.:...:.:......:|.....|
  Rat    62 FTNCKQWYQRKICGKSTVISYECCPGYEKVPGEKGCPAALPLSNLYETLGIVGSTTTQLYTDRTE 126

  Fly   129 HVVPGKIFDSYNGNGNSKEEEESFGNGNGHKIVFRKLEKSHNNVWLLNGQQILHKLRINENLMAI 193
            .:.|               |.|    |.|...:|    ...|..|.....::|..|..|.|:..:
  Rat   127 KLRP---------------EME----GPGSFTIF----APSNEAWSSLPAEVLDSLVSNVNIELL 168

  Fly   194 -AIDGYLGDRK-------------SPYSKRNIQETNNRYNDPQPLEQPNI-----TNAHAK---- 235
             |:..::.||:             |.|...|||    .::.|..:...|.     .:.||.
  Rat   169 NALRYHMVDRRVLTDELKHGMALTSMYQNSNIQ----IHHYPNGIVTVNCARLLKADHHATNGVV 229

  Fly   236 --VEPVIKESKASPLMSFLANMKTGTKVFQHFLSKSNLTRIMD-DNAYTVLIPSDNAFQRWHPID 297
              ::.||  |..:..:..:..::...:..:..::.|.|..::: |..:|:|.|::.||:: .|.:
  Rat   230 HLIDKVI--STVTNNIQQIIEIEDTFETLRAAVAASGLNTVLEGDGQFTLLAPTNEAFEK-IPAE 291

  Fly   298 WGFYPFSVPEFTESVLRNHFLPMQRPLRLADVRNMDEVVVTTMGGEDVVFHGQPTPTVNNVSIMS 362
            ........||....:|.||.|....... |.|..|   .:.|:||           |...|....
  Rat   292 TLNRILGDPEALRDLLNNHILKTAMCAE-AIVAGM---AMETLGG-----------TTLEVGCSG 341

  Fly   363 DYNLSNGNQVFIISEVLFVTEAVVSKLHQMHKDKETPPLLAFPWFGAQFLSHSFLALERDPRFTQ 427
            |....||..|....::| .|..|:..:.::........||.             ||.|.|  .:.
  Rat   342 DMLTINGKAVISNKDIL-ATNGVIHFIDELLIPDSAKTLLE-------------LASESD--VST 390

  Fly   428 ITRYLNSAEIAPHISG-ANYTFFVPEDRAFEKQGFDKLSDEVMASQRGVKMLLNHFVKGRLYNRD 491
            ....|..|.::.|:|| ...||..|.:..| |.|..::..::..      :||||.|||:|.::.
  Rat   391 AIDLLRQAGLSTHLSGKEQLTFLAPLNSVF-KDGVPRIDGQMKT------LLLNHMVKGQLASKY 448

  Fly   492 LRDNEVFETIGGGHIKITRNPGSNYTSVNNAQITESEVFVYN----LGTMYYLDDIL 544
            |...:..:|:||..:::       :...|:..|..|.:..::    .||::.:|.:|
  Rat   449 LYSGQTLDTLGGKKLRV-------FVYRNSLCIENSCIAAHDKKGRYGTLFTMDRML 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5758	NP_001286028.1	FAS1	281..380	CDD:214719	24/98 (24%)
CG5758	NP_001286028.1	FAS1	447..545	CDD:214719	25/102 (25%)
Tgfbi	NP_446254.1	Fasciclin	133..236	CDD:280607	22/114 (19%)
		Fasciclin	253..373	CDD:280607	30/136 (22%)
		Fasciclin	386..500	CDD:280607	31/129 (24%)
		Fasciclin	514..634	CDD:280607
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10900
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010