DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5758 and POSTN

DIOPT Version :9

Sequence 1:	NP_001286028.1	Gene:	CG5758 / 35083	FlyBaseID:	FBgn0032666	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_006466.2	Gene:	POSTN / 10631	HGNCID:	16953	Length:	836	Species:	Homo sapiens

Alignment Length:	480	Identity:	92/480 - (19%)
Similarity:	175/480 - (36%)	Gaps:	134/480 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 VLELYGYKPLPDLPYTLIVPKIDVRSIEKPRLKEFMLEHVVPGKIFDSYNGNGNSKEEEESFGNG 155
            :||..|    .|..:||..|..:  :.||  |...:||.::
Human   259 ILEALG----RDGHFTLFAPTNE--AFEK--LPRGVLERIM------------------------ 291

  Fly   156 NGHKIVFRKLEKSHNNVWLLNGQQILHKLRINENLMAIAI----DG---YLGDRKSPYSKRNIQE 213
             |.|:....|.|.|          ||:.|:.:|::|..|:    :|   .:|......:...|:.
Human   292 -GDKVASEALMKYH----------ILNTLQCSESIMGGAVFETLEGNTIEIGCDGDSITVNGIKM 345

  Fly   214 TNNRYNDPQPLEQPNITN---AHAKVEPVIKESKASPLMSFLANMKTGTKVFQHFLSKSNL-TRI 274
            .|         ::..:||   .|. ::.|:....|..::......:|   .|...:::..| :.:
Human   346 VN---------KKDIVTNNGVIHL-IDQVLIPDSAKQVIELAGKQQT---TFTDLVAQLGLASAL 397

  Fly   275 MDDNAYTVLIPSDNAF--------QRWHPIDWGFYPFSVPEFTESVLRNHFLPMQRPLRLADVRN 331
            ..|..||:|.|.:|||        ||               ..:.:|:||.|.::  :.|.::.|
Human   398 RPDGEYTLLAPVNNAFSDDTLSMDQR---------------LLKLILQNHILKVK--VGLNELYN 445

  Fly   332 MDEVVVTTMGGEDV-VFHGQPTPTVNNVSIMSDYNLSNGNQVFIISEVLFVTEAVVSKLHQMHKD 395
            ..  ::.|:||:.: ||..:....:.|..:...........:.|..|::...|   ..||:
Human   446 GQ--ILETIGGKQLRVFVYRTAVCIENSCMEKGSKQGRNGAIHIFREIIKPAE---KSLHE---- 501

  Fly   396 KETPPLLAFPWFGAQFLSHSFLALERDPRFTQITRYLNSAEIAPHIS-GANYTFFVPEDRAFEKQ 459
                                  .|::|.||:.....|.:|::...:: ..::|.|||.:.||  :
Human   502 ----------------------KLKQDKRFSTFLSLLEAADLKELLTQPGDWTLFVPTNDAF--K 542

  Fly   460 GFDKLSDEVMASQRGV--KMLLNHFVKGRLYNRDLRD--NEVFETIGGGHIKITRNPGSNYTSVN 520
            |......|::...:..  .::|.|...|....:....  ..:.:|..|.  ||.....::...||
Human   543 GMTSEEKEILIRDKNALQNIILYHLTPGVFIGKGFEPGVTNILKTTQGS--KIFLKEVNDTLLVN 605

  Fly   521 NAQITESEVFVYNLGTMYYLDDILY 545
            ..:..||::...| |.::.:|.:||
Human   606 ELKSKESDIMTTN-GVIHVVDKLLY 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5758	NP_001286028.1	FAS1	281..380	CDD:214719	22/107 (21%)
CG5758	NP_001286028.1	FAS1	447..545	CDD:214719	22/101 (22%)
POSTN	NP_006466.2	Fasciclin	109..230	CDD:280607
		Fasciclin	245..367	CDD:280607	31/160 (19%)
		Fasciclin	382..494	CDD:280607	27/133 (20%)
		Fasciclin	507..630	CDD:280607	28/128 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10900
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010