DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGHMBP2 and Ighmbp2

DIOPT Version :9

Sequence 1:	NP_002171.2	Gene:	IGHMBP2 / 3508	HGNCID:	5542	Length:	993	Species:	Homo sapiens
Sequence 2:	NP_113774.2	Gene:	Ighmbp2 / 29532	RGDID:	68325	Length:	988	Species:	Rattus norvegicus

Alignment Length:	1001	Identity:	775/1001 - (77%)
Similarity:	851/1001 - (85%)	Gaps:	21/1001 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLYGRLLV 65
            |.|:.|||||.:||.||||||||||||||||||:.||||||||||||||||||.|||||||:.||
  Rat     1 MDSSTVESFVAQQLQLLELERDAEVEERRSWQEHSSLKELQSRGVCLLKLQVSGQRTGLYGQRLV 65

Human    66 TFEPRRYGSAAALPSNSFTSGDIVGLYDAANEGSQLATGILTRVTQKSVTVAFDESHDFQLSLDR 130
            |||||::|.|..|||||||||||||||| .||.||||||:|||:|||||.|||||||||||:|||
  Rat    66 TFEPRKFGPAVVLPSNSFTSGDIVGLYD-TNESSQLATGVLTRITQKSVIVAFDESHDFQLNLDR 129

Human   131 ENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPASEIHPLTFFNTCLDTS 195
            ||:||||||||||||:||||||:.|||||||||||||:||.|.|.||||:||.||||:||.||.|
  Rat   130 ENTYRLLKLANDVTYKRLKKALLTLKKYHSGPASSLIDVLLGGSTPSPATEIPPLTFYNTTLDPS 194

Human   196 QKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKVLCCAPSNIAVDNLVERLALCKQ 260
            |||||.|||:|||:||||||||||||||||||||||||||||||||||||||||||||||||||:
  Rat   195 QKEAVSFALAQKEVAIIHGPPGTGKTTTVVEIILQAVKQGLKVLCCAPSNIAVDNLVERLALCKK 259

Human   261 RILRLGHPARLLESIQQHSLDAVLARSDSAQIVADIRKDIDQVFVKNKKTQDKREKSNFRNEIKL 325
            :|||||||||||||:|||||||||||||:||||||||:||||||.||||||||||||||||||||
  Rat   260 QILRLGHPARLLESVQQHSLDAVLARSDNAQIVADIRRDIDQVFGKNKKTQDKREKSNFRNEIKL 324

Human   326 LRKELKEREEAAMLESLTSANVVLATNTGASADGPLKLLPESYFDVVVIDECAQALEASCWIPLL 390
            ||||||||||||:::||::|:||||||||||.|||||||||.||||||:||||||||||||||||
  Rat   325 LRKELKEREEAAIVQSLSAADVVLATNTGASTDGPLKLLPEDYFDVVVVDECAQALEASCWIPLL 389

Human   391 KARKCILAGDHKQLPPTTVSHKAALAGLSLSLMERLAEEYGARVVRTLTVQYRMHQAIMRWASDT 455
            ||.||||||||||||||||||||||||||.||||||||::||.|||.|.|||||||||.||||:.
  Rat   390 KAPKCILAGDHKQLPPTTVSHKAALAGLSRSLMERLAEKHGAAVVRMLAVQYRMHQAITRWASEA 454

Human   456 MYLGQLTAHSSVARHLLRDLPGVAATEETGVPLLLVDTAGCGLFELEEEDEQSKGNPGEVRLVSL 520
            ||.||||||.|||.|||:||||||.||||.|||||:|||||||.||||||.||||||||||||:|
  Rat   455 MYHGQLTAHPSVAGHLLKDLPGVADTEETSVPLLLIDTAGCGLLELEEEDSQSKGNPGEVRLVTL 519

Human   521 HIQALVDAGVPARDIAVVSPYNLQVDLLRQSLVHRHPELEIKSVDGFQGREKEAVILSFVRSNRK 585
            ||||||||||.|.||||::|||||||||||||.::||||||||||||||||||||||:|||||||
  Rat   520 HIQALVDAGVQAGDIAVIAPYNLQVDLLRQSLSNKHPELEIKSVDGFQGREKEAVILTFVRSNRK 584

Human   586 GEVGFLAEDRRINVAVTRARRHVAVICDSRTVNNHAFLKTLVEYFTQHGEVRTAFEYLDDIVPEN 650
            |||||||||||||||||||||||||||||.||||||||||||:|||:||||||||||||||||||
  Rat   585 GEVGFLAEDRRINVAVTRARRHVAVICDSHTVNNHAFLKTLVDYFTEHGEVRTAFEYLDDIVPEN 649

Human   651 YSHENSQGSSHAATKPQGPATSTRTGSQRQEGGQEAAAPARQGRKKPAGKSLASEAPSQPSLNGG 715
            |:||.|:..| .|.||:.|.||.|..:..||..|||.|.....|:||:.|.|.|:...|.|....
  Rat   650 YTHEGSRSHS-CAPKPKCPTTSVRKPASAQESRQEARAATGHSRRKPSEKPLGSQVQPQHSSKAN 713

Human   716 SPEGVESQDGVDHFRAMIVEFMASKKMQLEFPPSLNSHDRLRVHQIAEEHGLRHDSSGEGKRRFI 780
            ..:.....|..:||||||.||:|||:.|||||.||:|||||||||:|||.||:|||:||||.|.|
  Rat   714 GSDRTGGTDRTEHFRAMIEEFVASKEAQLEFPTSLSSHDRLRVHQLAEEFGLKHDSTGEGKARHI 778

Human   781 TVSKRAPRPRAALGPPAGTGGPAPLQPVPPTPA------QTEQPPREQRGPDQPDLRTLHLERLQ 839
            |||:|:         |||:|...|..|.||:||      |.|||..:..|..|.||:.|||||||
  Rat   779 TVSRRS---------PAGSGSATPQPPSPPSPAQAEPEPQVEQPVGQPHGSTQLDLKALHLERLQ 834

Human   840 RVRSAQGQPASKEQQASGQQKLPEKKKKKAKGHPATDLPTEEDFEALVSAAVKADNTCGFAKCTA 904
            |.:..|.|  |:....|..||.|:|||||....||..||:||||:|||||.|||||||.|.||:|
  Rat   835 RQQGCQAQ--SQLGGGSRPQKAPQKKKKKEPKGPAMALPSEEDFDALVSAVVKADNTCSFTKCSA 897

Human   905 GVTTLGQFCQLCSRRYCLSHHLPEIHGCGERARAHARQRISREGVLYAGSGTKNGSLDPAKRAQL 969
            ..|||||||..|||||||||||||||||||:||||||||||||||||||||||:.:|||||||||
  Rat   898 STTTLGQFCMHCSRRYCLSHHLPEIHGCGEKARAHARQRISREGVLYAGSGTKDRALDPAKRAQL 962

Human   970 QRRLDKKLSELSNQRTSRR--KERGT 993
            ||:|||||.|||:||||::  |||||
  Rat   963 QRKLDKKLGELSSQRTSKKKEKERGT 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGHMBP2	NP_002171.2	TIGR00376	19..641	CDD:273041	542/621 (87%)
		AAA_19	198..256	CDD:289986	54/57 (95%)
		AAA_12	418..615	CDD:289832	169/196 (86%)
		SS DNA-binding. /evidence=ECO:0000250	638..785		84/146 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..723		26/71 (37%)
		R3H_Smubp-2_like	726..784	CDD:100070	43/57 (75%)
		DUF3628	<766..850	CDD:289100	43/89 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	782..828		18/51 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	841..879		15/37 (41%)
		Nuclear localization signal. /evidence=ECO:0000255	864..868		3/3 (100%)
		zf-AN1	897..934	CDD:279736	29/36 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..993		16/23 (70%)
Ighmbp2	NP_113774.2	TIGR00376	19..640	CDD:273041	542/621 (87%)
		SS DNA-binding. /evidence=ECO:0000250	637..783		84/146 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..722		25/71 (35%)
		R3H_Smubp-2_like	724..782	CDD:100070	43/57 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..820		28/63 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..872		16/38 (42%)
		Nuclear localization signal. /evidence=ECO:0000255	857..861		3/3 (100%)
		ZnF_AN1	890..930	CDD:197545	31/39 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..988		34/44 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83680293
Domainoid	1	1.000	394	1.000	Domainoid score	I10992
eggNOG	1	0.900	-	-		E1_COG1112
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1642
Inparanoid	1	1.050	1491	1.000	Inparanoid score	I2770
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG55486
OrthoDB	1	1.010	-	-		D13523at314146
OrthoFinder	1	1.000	-	-		FOG0005858
OrthoInspector	1	1.000	-	-		oto144287
orthoMCL	1	0.900	-	-		OOG6_102586
Panther	1	1.100	-	-	LDO	PTHR43788
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4257
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270