DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31741 and CD36

DIOPT Version :9

Sequence 1:	NP_724088.2	Gene:	CG31741 / 35079	FlyBaseID:	FBgn0051741	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_000063.2	Gene:	CD36 / 948	HGNCID:	1663	Length:	472	Species:	Homo sapiens

Alignment Length:	468	Identity:	111/468 - (23%)
Similarity:	200/468 - (42%)	Gaps:	46/468 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GGLILAIGIFLASAWPAVSRQWIRSLLPLAPNSFIYNRWVTTPTPVYSTVFLFNWTNPGDLNTEG 83
            ||:::.:|..|.       ::.|:..:.|...:..:..||.|.|.||...::|:..||.::....
Human    23 GGILMPVGDLLI-------QKTIKKQVVLEEGTIAFKNWVKTGTEVYRQFWIFDVQNPQEVMMNS 80

  Fly    84 VKPHFEQLGPYTF-----SDFKVKEDLEWNQPQVTYFGKRTWHFLPEKSNGSLDDVVIAPHFPTL 143
            .....:|.||||:     :...|.:|.|.|  .|::.......|.|..|.|:..|     :|..|
Human    81 SNIQVKQRGPYTYRVRFLAKENVTQDAEDN--TVSFLQPNGAIFEPSLSVGTEAD-----NFTVL 138

  Fly   144 TAA------LYSRRLRRILRKVMNFTLNREGGATHMTHTAGQWLFDGYYDHLLDFVEQLHSPLLP 202
            ..|      :|.   .:.::.::|..:|:...:.....|..:.|: ||.|..|..|.      .|
Human   139 NLAVAAASHIYQ---NQFVQMILNSLINKSKSSMFQVRTLRELLW-GYRDPFLSLVP------YP 193

  Fly   203 VYDNTFGWFYERNNSKTAEGNFTLHTGRGDLSQLGDLLLWNGENTTGFYPGECGKVNGSTGELWS 267
            | ..|.|.||..||  ||:|.:.:..|:.::|::..:..:.|:....::...|..:||:....:.
Human   194 V-TTTVGLFYPYNN--TADGVYKVFNGKDNISKVAIIDTYKGKRNLSYWESHCDMINGTDAASFP 255

  Fly   268 PYRTWDQPTTIFLPDAARYLNLFPKENLTIDGIDVWRYESTNLTIDNGQLSPDTECFCLK---NR 329
            |:....|....|..|..|.:....:.::.:.||.|:|:...:....:...:||..|||.:   ::
Human   256 PFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVYRFVLPSKAFASPVENPDNYCFCTEKIISK 320

  Fly   330 ECPRNGVLDYGPPAFNGPFYMSHPHFFLTDQMYRENTTGLQPEESEHGMYVIMEPTLGIPLSLRG 394
            .|...||||........|.|:|.|||........|...||.|.|.||..|:.:||..|..|....
Human   321 NCTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGLNPNEEEHRTYLDIEPITGFTLQFAK 385

  Fly   395 QLMISTKVVRDEAIDLFKNVAYDHYAPLFTMRLHAELDEGLTKLLKLALNAAI--IGMYTGIGLV 457
            :|.::..|...|.|.:.||:..::..|:..:.....:.:....:.:..:...|  :|:   |.::
Human   386 RLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNETGTIGDEKANMFRSQVTGKINLLGL---IEMI 447

  Fly   458 LLGMSIVVTGIFI 470
            ||.:.:|:...|:
Human   448 LLSVGVVMFVAFM 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31741	NP_724088.2	CD36	21..469	CDD:279474	108/463 (23%)
CD36	NP_000063.2	CD36	14..463	CDD:395898	111/468 (24%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000269\|PubMed:1371676	93..120		5/28 (18%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000269\|PubMed:20037584	460..472		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820