Protein Alignment CG31741 and Scarb2

DIOPT Version :10

• Sequence 1: NP_724088.2
• Gene: CG31741 / 35079
• FlyBaseID: FBgn0051741
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_031670.1
• Gene: Scarb2 / 12492
• MGIID: 1196458
• Length: 478
• Species: Mus musculus
• Alignment Length: 485
• Identity: 110/485 - (22%)
• Similarity: 211/485 - (43%)
• Gaps: 46/485 - (9%)

  Fly     5 CCSVRQQKIWVFSMGG------LILAIGIFLASAWPAVSRQWIRSLLPLAPNSFIYNRWVTTPTP 63
            ||         |...|      |:.::.:.:|..:.....|.|...:.|...:.::|.|...|.|
Mouse     4 CC---------FYTAGTLSLLLLVTSVTLLVARVFQKAVDQTIEKNMVLQNGTKVFNSWEKPPLP 59

  Fly    64 VYSTVFLFNWTNPGDLNTEGVKPHFEQLGPYTFSDFKVKEDLEWNQPQVTYFGKRTWHFLPEKSN 128
            ||...:.||.|||.:: .:|..|..|::||||:.:.:.|.::::.:...|........::.|::.
Mouse    60 VYIQFYFFNVTNPEEI-LQGEIPLLEEVGPYTYRELRNKANIQFGENGTTISAVTNKAYVFERNQ 123

  Fly   129 GSLD---DVVIAPHFPTLTAALYSRRLRRILRKVMNFTLNREGGATHMTHTAGQWLFDGYYDHLL 190
            ...|   |::...:.|.||....::  ..:||:::...|........:.||..:.|: ||.|.:|
Mouse   124 SVGDPNVDLIRTINIPLLTVVDLAQ--LTLLRELIEAMLKAYQQKLFVIHTVHELLW-GYKDEIL 185

  Fly   191 DFVEQLHSPLLPVYDNTFGWFYERNNSKTAEGNFTLHTGRGDLSQLGDLLLWNGENTTGFYPGE- 254
            ..|......:.|    .||.|||||.  |.:|.:...||..:......::.|||:.:..::..:
Mouse   186 SLVHIFKPDVSP----NFGLFYERNG--TNDGEYVFLTGEDNYLNFSKIVEWNGKTSLDWWTTDT 244

  Fly   255 CGKVNGSTGELWSPYRTWDQPTTIFLPDAARYLNLFPKENLTIDGIDVWRYESTNLTIDNGQLSP 319
            |..:||:.|:.:.|..:.|:...:|..|..|.:::.......::|:..:||:.....:.|   :.
Mouse   245 CNMINGTDGDSFHPLISKDEVLYLFPSDLCRSVHITFSSFENVEGLPAFRYKVPAEILAN---TS 306

  Fly   320 DTECFCLKNRECPRNGVLDYGPPAFNGPFYMSHPHFFLTDQMYRENTTGLQPEESEHGMYVIMEP 384
            :...||:....|..:|||:........|..||.|||:..|:.:.....|:.|.:.||..:|.:.|
Mouse   307 ENAGFCIPEGNCMDSGVLNISICKNGAPIIMSFPHFYQADEKFVSAIKGMHPNKEEHESFVDINP 371

  Fly   385 TLGIPLSLRGQLMISTKVVR-DEAIDL--FKNVAYDHYAPLFTMRLHAELDEGLTKLLKLALNAA 446
            ..||.|....:..|:|.|.: |:.::.  .:.:.:    |:..:.....:|:.....||..:|..
Mouse   372 LTGIILRGAKRFQINTYVRKLDDFVETGDIRTMVF----PVMYLNESVLIDKETANQLKSVINTT 432

  Fly   447 IIGMYTGIGLVLLGMSIVVTGIFITKKHKW 476
            ::  .|.|..:::.:     |:|......|
Mouse   433 LV--VTNIPYIIMAL-----GVFFGLVFTW 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31741	NP_724088.2	CD36	19..471	CDD:460076	106/464 (23%)
Scarb2	NP_031670.1	CD36	28..457	CDD:460076	104/452 (23%)
		Important for interaction with GBA1	155..191		9/36 (25%)