DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31741 and Scarb2

DIOPT Version :9

Sequence 1:	NP_724088.2	Gene:	CG31741 / 35079	FlyBaseID:	FBgn0051741	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_446453.1	Gene:	Scarb2 / 117106	RGDID:	621882	Length:	478	Species:	Rattus norvegicus

Alignment Length:	480	Identity:	115/480 - (23%)
Similarity:	212/480 - (44%)	Gaps:	45/480 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CCSVRQQKIWVFSMGG------LILAIGIFLASAWPAVSRQWIRSLLPLAPNSFIYNRWVTTPTP 63
            ||         |...|      |:.::.:.:|..:.....|.|...:.|...:.:::.|...|.|
  Rat     4 CC---------FYTAGTLSLLLLVTSVTLLVARVFQKAVDQTIEKNMVLQNGTKVFDSWEKPPLP 59

  Fly    64 VYSTVFLFNWTNPGDLNTEGVKPHFEQLGPYTFSDFKVKEDLEWNQPQVTYFGKRTWHFLPEKSN 128
            ||...:.||.|||.:: .:|..|..|::||||:.:.:.|.::::.:...|........::.|::.
  Rat    60 VYIQFYFFNVTNPEEI-LQGEIPLLEEVGPYTYRELRNKANVQFGENGTTISAVTNKAYIFERNQ 123

  Fly   129 GSLD---DVVIAPHFPTLTAALYSRRLRRILRKVMNFTLNREGGATHMTHTAGQWLFDGYYDHLL 190
            ...|   |::...:.|.||....::  :..||:::...|........:|||..:.|: ||.|.:|
  Rat   124 SVGDPTVDLIRTINIPLLTVVEMAQ--QPFLREIIEAMLKAYQQTLFVTHTVHELLW-GYKDEVL 185

  Fly   191 DFVEQLHSPLLPVYDNTFGWFYERNNSKTAEGNFTLHTGRGDLSQLGDLLLWNGENTTGFYPGE- 254
            ..|......:.|    .||.|||||.  |.:|.:...||..:......::.|||:.:..::..:
  Rat   186 SLVHIFRPDVSP----NFGLFYERNG--TNDGEYVFLTGEDNYLNFTKIVEWNGKTSLDWWTTDT 244

  Fly   255 CGKVNGSTGELWSPYRTWDQPTTIFLPDAAR--YLNLFPKENLTIDGIDVWRYESTNLTIDNGQL 317
            |..:||:.|:.:.|..:.|:...||..|..|  |:.....||  ::|:..:||:.....:.|
  Rat   245 CNMINGTDGDSFHPLISKDETLYIFPSDFCRSVYITFSSFEN--VEGLPAFRYKVPAEILAN--- 304

  Fly   318 SPDTECFCLKNRECPRNGVLDYGPPAFNGPFYMSHPHFFLTDQMYRENTTGLQPEESEHGMYVIM 382
            |.:...||:....|...|||:........|..||.|||:..|:.:.....|::|.:.||..:|.:
  Rat   305 SSENAGFCIPEGNCMDAGVLNVSICKNGAPIIMSFPHFYQADEKFVSAIKGMRPNKEEHESFVDI 369

  Fly   383 EPTLGIPLSLRGQLMISTKVVR-DEAIDL--FKNVAYDHYAPLFTMRLHAELDEGLTKLLKLALN 444
            .|..||.|....:..|:|.|.: |:.::.  .:.:.:    |:..:.....:|:.....||..:|
  Rat   370 NPLTGIILRGAKRFQINTYVKKLDDFVETGNIRTMVF----PVMYLNESVLIDKETASQLKSVIN 430

  Fly   445 AAIIGMYTGIGLVLLGMSIVVTGIF 469
            ..:|  .|.|..:::.:.:....||
  Rat   431 TTLI--VTNIPYIIMALGVFFGLIF 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31741	NP_724088.2	CD36	21..469	CDD:279474	109/456 (24%)
Scarb2	NP_446453.1	CD36	34..457	CDD:395898	109/441 (25%)
Scarb2	NP_446453.1	Important for interaction with GBA. /evidence=ECO:0000250	155..191		10/36 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45589
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930