DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and TLR10

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001017388.1	Gene:	TLR10 / 81793	HGNCID:	15634	Length:	811	Species:	Homo sapiens

Alignment Length:	486	Identity:	107/486 - (22%)
Similarity:	173/486 - (35%)	Gaps:	168/486 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 DVPELK-----VLKCRNCQLKKINPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKRLTKVLLDG 259
            |.|||.     :..|.|..|:|:..   :|.|..:.|||..|....|...:|..|.:|..::|..
Human    20 DAPELPEERELMTNCSNMSLRKVPA---DLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCH 81

  Fly   260 NQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEP--QSIRSLS 322
            |::..:..:.|...|.|.:||||.|||..|   ::..|..|.:||||:|....: |  :...::|
Human    82 NRIQQLDLKTFEFNKELRYLDLSNNRLKSV---TWYLLAGLRYLDLSFNDFDTM-PICEEAGNMS 142

  Fly   323 NLLTLNISGNVLMDLREMRETFEPLIYYFFLTCSKLFFQLIPQLTHLAIADMGTMPVGLLHPFKQ 387
            :|..|.:||     .:..:..|:. |.:..|....|.|:.:|..      :.|::|:
Human   143 HLEILGLSG-----AKIQKSDFQK-IAHLHLNTVFLGFRTLPHY------EEGSLPI-------- 187

  Fly   388 LRYLNISGNSLNNTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQGI------------RNVR 440
                      ||.|.|.::.| .:..|..|.|:   ||....:|.:..|            ||:.
Human   188 ----------LNTTKLHIVLP-MDTNFWVLLRD---GIKTSKILEMTNIDGKSQFVSYEMQRNLS 238

  Fly   441 LDNN----------PLICDECHMGKLINVVRQLQWKWDTYPICFLPKSLRGAEINNLDING---- 491
            |:|.          .|:.|:..:        .||:.|.|        |:...:|.|:...|
Human   239 LENAKTSVLLLNKVDLLWDDLFL--------ILQFVWHT--------SVEHFQIRNVTFGGKAYL 287

  Fly   492 -------------------LHTCLTFITDEE---------------QNAA---------STSYNF 513
                               :|..:.:|..::               .||.         .|.:.:
Human   288 DHNSFDYSNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQY 352

  Fly   514 LEHGG----------------LNTLAILGGIIFVLIAVIILSLVACFSKNRARYYTREDHLNGSE 562
            |....                |.||.:.|.      .:..||||:||:.|     |..:||:.|:
Human   353 LNFANNILTDELFKRTIQLPHLKTLILNGN------KLETLSLVSCFANN-----TPLEHLDLSQ 406

  Fly   563 SKCLEKNLEATTITTLGNGSSPTTTTTLTLA 593
            :....||.|        |.|.|.|...:.|:
Human   407 NLLQHKNDE--------NCSWPETVVNMNLS 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380
		leucine-rich repeat	108..131	CDD:275380
		LRR_8	131..190	CDD:290566
		leucine-rich repeat	132..155	CDD:275380
		LRR_RI	151..422	CDD:238064	60/228 (26%)
		leucine-rich repeat	156..179	CDD:275380
		LRR_8	178..262	CDD:290566	20/66 (30%)
		leucine-rich repeat	180..203	CDD:275380	1/2 (50%)
		leucine-rich repeat	204..251	CDD:275380	14/51 (27%)
		leucine-rich repeat	252..275	CDD:275380	4/22 (18%)
		LRR_8	274..334	CDD:290566	23/61 (38%)
		leucine-rich repeat	276..299	CDD:275380	10/22 (45%)
		LRR_4	298..342	CDD:289563	12/45 (27%)
		leucine-rich repeat	300..323	CDD:275380	7/24 (29%)
		leucine-rich repeat	388..411	CDD:275380	5/22 (23%)
TLR10	NP_001017388.1	LRR 1	24..46		5/24 (21%)
		LRR 2	49..70		6/20 (30%)
		leucine-rich repeat	50..73	CDD:275378	7/22 (32%)
		LRR_8	72..129	CDD:316378	21/59 (36%)
		LRR 3	73..94		4/20 (20%)
		leucine-rich repeat	74..97	CDD:275378	4/22 (18%)
		LRR 4	97..118		10/23 (43%)
		leucine-rich repeat	98..112	CDD:275378	9/16 (56%)
		leucine-rich repeat	119..143	CDD:275378	7/24 (29%)
		LRR 5	119..139		7/20 (35%)
		LRR 6	143..166		6/28 (21%)
		leucine-rich repeat	144..155	CDD:275378	4/15 (27%)
		LRR	289..>522	CDD:227223	29/160 (18%)
		LRR 7	296..321		2/24 (8%)
		LRR 8	325..348		2/22 (9%)
		LRR 9	349..368		1/18 (6%)
		leucine-rich repeat	350..373	CDD:275380	1/22 (5%)
		LRR 10	373..394		9/26 (35%)
		leucine-rich repeat	374..398	CDD:275380	11/34 (32%)
		LRR 11	398..419		7/28 (25%)
		leucine-rich repeat	399..422	CDD:275380	9/30 (30%)
		LRR 12	422..442		2/8 (25%)
		leucine-rich repeat	423..444	CDD:275380	1/7 (14%)
		LRR 13	444..465
		leucine-rich repeat	445..467	CDD:275380
		LRR 14	467..488
		leucine-rich repeat	468..490	CDD:275380
		LRR 15	489..509
		leucine-rich repeat	491..513	CDD:275380
		LRRCT	522..574	CDD:214507
		TIR	633..775	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900