DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rdo and TLR4

DIOPT Version :10

Sequence 1:NP_001286024.1 Gene:rdo / 35077 FlyBaseID:FBgn0243486 Length:757 Species:Drosophila melanogaster
Sequence 2:NP_612564.1 Gene:TLR4 / 7099 HGNCID:11850 Length:839 Species:Homo sapiens


Alignment Length:671 Identity:142/671 - (21%)
Similarity:247/671 - (36%) Gaps:191/671 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 QFMKLEILRITDSNLP--------------AIGAESFWGLKYLRILDLSKNNITNITENNFRGQD 130
            |.|:|...:|.| |||              .:|:.||:....|::||||:..|..|.:..::...
Human    39 QCMELNFYKIPD-NLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLS 102

  Fly   131 NLLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQ- 194
            :|..|.|:.|.:..:|...|..|:.|::|...:.::..|.......|..||.|:::.|.:|..: 
Human   103 HLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKL 167

  Fly   195 PDVFRDVPELKVLKCRNCQLKKI---NPQMYNLLPLLS-ELDLGRNEFKFLDKDEFRDVKRLTKV 255
            |:.|.::..|:.|...:.:::.|   :.::.:.:|||: .|||..|...|:....|::: ||.|:
Human   168 PEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEI-RLHKL 231

  Fly   256 LLDGN--QLSVV-----------VDQL----FRMQKSLNHLDLS--------------------- 282
            .|..|  .|:|:           |.:|    ||.:.:|...|.|                     
Human   232 TLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYY 296

  Fly   283 -------YNRLAKVPNDSFLQLTNLTFLDLSYN-----------KLVRLEPQSIRSLSNL-LTLN 328
                   :|.|..|.:.|.:.:|.....|.|||           |..:.....::||..| .|.|
Human   297 LDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSN 361

  Fly   329 ISGNV----------LMDLREMRETFE----------------PLIYYFFLTCSKLFFQLIPQLT 367
            ..||.          .:||.....:|:                .|.:...:|.|..|..| .||.
Human   362 KGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGL-EQLE 425

  Fly   368 HL-----AIADMGTMPV----------------------GLLHPFKQLRYLNISGNSLNNTAL-E 404
            ||     .:..|....|                      |:.:....|..|.::|||.....| :
Human   426 HLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPD 490

  Fly   405 VIDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPLICDECHMGKLINVVRQLQWKWD- 468
            :....|.|.|||||:.||..:|......:..::.:.:.:|.....:....|.:|.::.|.:..: 
Human   491 IFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNH 555

  Fly   469 -----TYPICFLPKSLRGAEINNLDINGLHTC-----LTFITDEEQ--------NAASTSYNFLE 515
                 ...:...|.||  |.:|....:...||     |.:|.|:.|        ..|:.|    :
Human   556 IMTSKKQELQHFPSSL--AFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPS----D 614

  Fly   516 HGGLNTL---------------AILGGIIFVLIAVII-------LSLVACFSKNRAR-------- 550
            ..|:..|               ::|..::..::||::       :.|..|....|..        
Human   615 KQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLMLLAGCIKYGRGENIYDAFVI 679

  Fly   551 YYTREDHLNGSESKCLEKNLE 571
            |.::::....:|   |.||||
Human   680 YSSQDEDWVRNE---LVKNLE 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdoNP_001286024.1 LRR 69..>446 CDD:443914 111/495 (22%)
leucine-rich repeat 84..107 CDD:275380 9/36 (25%)
leucine-rich repeat 108..131 CDD:275380 7/22 (32%)
leucine-rich repeat 132..155 CDD:275380 7/22 (32%)
leucine-rich repeat 156..179 CDD:275380 4/22 (18%)
leucine-rich repeat 180..203 CDD:275380 7/23 (30%)
leucine-rich repeat 204..251 CDD:275380 12/50 (24%)
leucine-rich repeat 252..275 CDD:275380 10/39 (26%)
leucine-rich repeat 276..299 CDD:275380 7/50 (14%)
leucine-rich repeat 300..323 CDD:275380 7/33 (21%)
leucine-rich repeat 388..411 CDD:275380 6/23 (26%)
TLR4NP_612564.1 LRR 1 55..76 3/20 (15%)
leucine-rich repeat 56..79 CDD:275378 3/22 (14%)
LRR_8 57..114 CDD:404697 14/56 (25%)
PPP1R42 76..>190 CDD:455733 27/113 (24%)
LRR 2 79..100 7/20 (35%)
leucine-rich repeat 80..103 CDD:275378 7/22 (32%)
LRR 3 103..124 6/20 (30%)
leucine-rich repeat 104..127 CDD:275378 7/22 (32%)
LRR 4 127..148 3/20 (15%)
leucine-rich repeat 128..176 CDD:275378 11/47 (23%)
leucine-rich repeat 130..151 CDD:275380 3/20 (15%)
LRR 5 151..172 6/20 (30%)
LRR 6 176..199 3/22 (14%)
leucine-rich repeat 177..190 CDD:275378 2/12 (17%)
leucine-rich repeat 195..224 CDD:275380 8/28 (29%)
LRR 7 205..225 6/19 (32%)
LRR 8 227..247 7/19 (37%)
LRR 290..>581 CDD:443914 57/293 (19%)
LRR 9 331..351 1/19 (5%)
LRR 10 352..373 7/20 (35%)
leucine-rich repeat 353..374 CDD:275380 6/20 (30%)
LRR 11 374..394 3/19 (16%)
LRR 12 400..422 5/22 (23%)
leucine-rich repeat 401..423 CDD:275380 5/22 (23%)
LRR 13 423..444 6/20 (30%)
leucine-rich repeat 424..448 CDD:275380 5/23 (22%)
LRR 14 448..456 0/7 (0%)
leucine-rich repeat 449..472 CDD:275380 1/22 (5%)
LRR 15 472..495 6/22 (27%)
leucine-rich repeat 473..497 CDD:275380 6/23 (26%)
LRR 16 497..518 9/20 (45%)
leucine-rich repeat 498..521 CDD:275380 9/22 (41%)
LRR 17 521..542 1/20 (5%)
LRR 18 545..565 1/19 (5%)
leucine-rich repeat 546..570 CDD:275380 2/23 (9%)
LRRCT 579..625 CDD:214507 10/49 (20%)
TIR 674..815 CDD:214587 7/27 (26%)

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