DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and Tlr8

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001094479.1	Gene:	Tlr8 / 684440	RGDID:	1590327	Length:	1029	Species:	Rattus norvegicus

Alignment Length:	663	Identity:	150/663 - (22%)
Similarity:	239/663 - (36%)	Gaps:	205/663 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 QAICTKGGLNSLLSPNELDVDVKVIIIRGPRNSITIGP---ALRQFMKLEIL------------- 87
            |.|.:...|..|.|...||:... .|.:.....|||.|   .||...||.:.
  Rat   317 QEIASGAFLTKLPSLQTLDLSFN-FIHKEYLQYITISPNFSMLRSLRKLHLKGYVFRELKKEHFK 380

  Fly    88 ------RITDSNL-----PAIGAESFWGLKYLRILDLSKNNITNITE------------------ 123
                  .:|..||     ..|..::|.....|:::.||.|.|.::.:
  Rat   381 PLQNLPNLTTINLGINFIEKIDFKAFQDFPNLKVIYLSGNRIASVIDGTDHSSWRNRLRKPLSTD 445

  Fly   124 --------NNFRGQDNLLE---------LDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQ 171
                    |.:...:.|::         ||||.|.:..:..|.|....|:..|||:.|:..:::.
  Rat   446 YDEFDPHMNFYHSTEPLIKPQCTTYGKALDLSLNNIFVIGKSQFEGFQDIACLNLSFNANGQVLN 510

  Fly   172 -RNFFMLSRLKYLDLSGNPLQDLQPDVFRDVPELKVLK-CRNCQLKKINPQMYNL-----LPLLS 229
             ..|..:..:|||||:.|.|.......|.|:.:|:||. ..|.....|....:.|     |..|.
  Rat   511 GTEFSSMPHIKYLDLTNNRLDFDDNQTFSDLHDLEVLDLSHNAHYFSIAGVTHRLGFIQNLIKLK 575

  Fly   230 ELDLGRNEFKFLDKDEFR-DVKRLTKVLLDGNQLSVVVD-------QLFRMQKSLNHLDLSYNRL 286
            .|:|..|....| .||:: ..|.|.:::..||:|..:.:       .:|...::|..||||||.|
  Rat   576 VLNLSHNGIYTL-TDEYKLQSKSLKELVFSGNRLDRLWNANDGKYWSIFTSLETLTRLDLSYNNL 639

  Fly   287 AKVPNDSFLQL-TNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVLMDLREMRETFEPLIYY 350
            .::||::||.| .:|..|.::.|:|.......::...:|..|::..|.|               |
  Rat   640 QQIPNEAFLNLPQSLQELHINDNRLRFFNWTLLQYFPHLHVLDLGRNEL---------------Y 689

  Fly   351 FFLTCSKLFFQLIPQL-------THLAIADMGTMPVGLLHPFKQLRYLNISGNS---LNNTALEV 405
            |...|...|...:..|       :||        |.|.|...:.|.||::|.|:   :|.::|:.
  Rat   690 FLTNCLSKFTHSLKTLLLNHNHFSHL--------PAGFLSEARNLVYLDLSFNTIKMINKSSLQT 746

  Fly   406 IDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPLICDECHMGKLINVVRQLQWKWDTY 470
             :....|..|||..|..     |....|...|: .|:.||.:    .:.:|::|
  Rat   747 -ETKTNLSVLDLQGNHF-----DCTCDISDFRS-WLEENPHV----RIPRLVDV----------- 789

  Fly   471 PICFLPKSLRGAEINNLDINGLHTCLTFITDEEQNAASTSYNFLEHGGLNTLAILGGIIFVLIAV 535
             ||..|...|...:.:||   |.||   ::|                  .|.|||....|:..:.
  Rat   790 -ICSNPGDQRWKSVMSLD---LTTC---VSD------------------TTAAILFFFTFLTTST 829

  Fly   536 IILSLVA--------------CFSKNRA---------------RYYTRED------------HLN 559
            ::|:.:.              |.:|.|.               .|.|::.            ||.
  Rat   830 VLLAALVHHLFYWDVWFIYHMCSAKLRGYRSSSTSQTFYDAYISYDTKDASVTDWVINELRYHLE 894

  Fly   560 GSESK----CLEK 568
            .||.|    |||:
  Rat   895 ESEDKSVLLCLEE 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	6/46 (13%)
		leucine-rich repeat	108..131	CDD:275380	6/48 (13%)
		LRR_8	131..190	CDD:290566	20/68 (29%)
		leucine-rich repeat	132..155	CDD:275380	8/31 (26%)
		LRR_RI	151..422	CDD:238064	78/296 (26%)
		leucine-rich repeat	156..179	CDD:275380	5/23 (22%)
		LRR_8	178..262	CDD:290566	27/90 (30%)
		leucine-rich repeat	180..203	CDD:275380	9/22 (41%)
		leucine-rich repeat	204..251	CDD:275380	14/53 (26%)
		leucine-rich repeat	252..275	CDD:275380	5/29 (17%)
		LRR_8	274..334	CDD:290566	20/60 (33%)
		leucine-rich repeat	276..299	CDD:275380	13/23 (57%)
		LRR_4	298..342	CDD:289563	8/43 (19%)
		leucine-rich repeat	300..323	CDD:275380	4/22 (18%)
		leucine-rich repeat	388..411	CDD:275380	7/25 (28%)
Tlr8	NP_001094479.1	PRK15370	<21..>218	CDD:185268
		leucine-rich repeat	62..85	CDD:275380
		leucine-rich repeat	86..119	CDD:275380
		leucine-rich repeat	120..140	CDD:275380
		PLN00113	141..>664	CDD:215061	86/348 (25%)
		leucine-rich repeat	141..164	CDD:275380
		leucine-rich repeat	165..194	CDD:275380
		leucine-rich repeat	195..215	CDD:275380
		leucine-rich repeat	216..239	CDD:275380
		leucine-rich repeat	240..280	CDD:275380
		leucine-rich repeat	281..304	CDD:275380
		leucine-rich repeat	305..324	CDD:275380	2/6 (33%)
		leucine-rich repeat	331..387	CDD:275380	11/56 (20%)
		leucine-rich repeat	388..411	CDD:275380	5/22 (23%)
		leucine-rich repeat	467..494	CDD:275380	7/26 (27%)
		leucine-rich repeat	495..510	CDD:275380	4/14 (29%)
		leucine-rich repeat	520..543	CDD:275380	9/22 (41%)
		leucine-rich repeat	544..573	CDD:275380	7/28 (25%)
		leucine-rich repeat	574..597	CDD:275380	7/23 (30%)
		leucine-rich repeat	598..628	CDD:275380	5/29 (17%)
		PRK15370	<629..>739	CDD:185268	36/132 (27%)
		leucine-rich repeat	629..653	CDD:275380	13/23 (57%)
		leucine-rich repeat	654..677	CDD:275380	4/22 (18%)
		leucine-rich repeat	678..701	CDD:275380	8/37 (22%)
		leucine-rich repeat	702..725	CDD:275380	6/30 (20%)
		leucine-rich repeat	726..745	CDD:275380	6/18 (33%)
		PCC	730..>813	CDD:188093	26/111 (23%)
		TIR	868..1004	CDD:214587	10/40 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900