Protein Alignment rdo and ISLR2

DIOPT Version :10

• Sequence 1: NP_001286024.1
• Gene: rdo / 35077
• FlyBaseID: FBgn0243486
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_065902.1
• Gene: ISLR2 / 57611
• HGNCID: 29286
• Length: 745
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 111/578 - (19%)
• Similarity: 188/578 - (32%)
• Gaps: 168/578 - (29%)

  Fly   211 NCQLKKINPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVVDQLFRMQKS 275
            :|..|::......|...::.|.|..|:...|.:..|.||.::|.:.|..|::..|......:...
Human    36 DCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQ 100

  Fly   276 LNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVLMDLREM 340
            |.:||||:|.::..|......|:.|..|.:::|:|..|...::.:|.:|.:|.|:.|.|..|..
Human   101 LKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAP- 164

  Fly   341 RETFEPL-------IYY--FFLTCSKLFFQLIPQLTHLAIADMGTMPVGLLHPFKQLRYLNISGN 396
             .||:.|       :|:  |...|..::.|.....|.:::.:..::...
Human   165 -GTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACA---------------- 212

  Fly   397 SLNNTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQG---------IRNVRLDNNPLICDECH 452
              :..||:.: |...|..|..:...:| :|.:..|...|         :.:...|.:|
Human   213 --SPPALQGV-PVYRLPALPCAPPSVH-LSAEPPLEAPGTPLRAGLAFVLHCIADGHP------- 266

  Fly   453 MGKLINVVRQLQWKWDTYPICFLPKSLRGAEINNLDINGLHTCL--TFITDEEQNAASTSYNFLE 515
                   ..:|||:                    |.|.|....|  ..::.|:....:.......
Human   267 -------TPRLQWQ--------------------LQIPGGTVVLEPPVLSGEDDGVGAEEGEGEG 304

  Fly   516 HGGLNT----------------------LAILGGIIFVLIAVIILSLVACFSKNRARYYTREDHL 558
            .|.|.|                      ||:..|.:          ||...|...|..||...|.
Human   305 DGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSL----------LVPLLSAKEAGVYTCRAHN 359

  Fly   559 N-GSESKCLEKNLEATTITTLG------------NGSSPTTTTTLTL-----ATSPAAPNGPKTN 605
            . |:.|..:...:.||     |            :|.:||:....|.     :..|:.|.| |..
Human   360 ELGANSTSIRVAVAAT-----GPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEG-KIK 418

  Fly   606 GQGLSLSPANGSTPVHGISD-DKGKEINFTFPVDDRVCTIDELMPSPPPPPQQHPHPNMGSLMYS 669
            ||||:.....|.|......| .:|:|      .:|::..         .|.::....|.....|.
Human   419 GQGLAKVSILGETETEPEEDTSEGEE------AEDQILA---------DPAEEQRCGNGDPSRYV 468

  Fly   670 VSHSPNSATTL--------------AAVAAAATVIP------PGAPSHSSMPTPTPTP 707
            .:|:.|.:..|              |...|...:.|      ||.......|.|...|
Human   469 SNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRP 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	LRR	69..>446	CDD:443914	52/252 (21%)
		leucine-rich repeat	84..107	CDD:275380
		leucine-rich repeat	108..131	CDD:275380
		leucine-rich repeat	132..155	CDD:275380
		leucine-rich repeat	156..179	CDD:275380
		leucine-rich repeat	180..203	CDD:275380
		leucine-rich repeat	204..251	CDD:275380	10/39 (26%)
		leucine-rich repeat	252..275	CDD:275380	4/22 (18%)
		leucine-rich repeat	276..299	CDD:275380	8/22 (36%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	388..411	CDD:275380	3/22 (14%)
ISLR2	NP_065902.1	leucine-rich repeat	36..52	CDD:275380	3/15 (20%)
		LRR	<51..>183	CDD:443914	35/133 (26%)
		LRR 1	52..73		5/20 (25%)
		leucine-rich repeat	53..76	CDD:275380	7/22 (32%)
		LRR 2	76..97		4/20 (20%)
		leucine-rich repeat	77..100	CDD:275380	4/22 (18%)
		LRR 3	100..123		7/22 (32%)
		leucine-rich repeat	101..124	CDD:275380	8/22 (36%)
		LRR 4	124..145		5/20 (25%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		LRR 5	148..169		8/22 (36%)
		leucine-rich repeat	149..172	CDD:275380	9/24 (38%)
		PCC	154..>228	CDD:188093	16/94 (17%)
		Ig_3	232..359	CDD:464046	26/171 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..326		4/38 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..466		22/111 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..722