DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and Tollo

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster

Alignment Length:	622	Identity:	151/622 - (24%)
Similarity:	252/622 - (40%)	Gaps:	137/622 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLLFSLCIMP----AMFSNTKRKCPTECQCSMDDLDRYQAICTKGGLNSLLSPNELDVDVKVIII 65
            ::|.:.|::|    |:......:.|.||:.|.........:|....:||.|.    :.:..||
  Fly     9 YVLIATCVIPIFGAALSKTVLYQAPDECRWSGGGEHDITLVCHLRTINSELE----NTNFSVI-- 67

  Fly    66 RGPRNSI--------------TIGP-ALRQFMKLEILRITDSNLPAIGAESFWGLKYLR------ 109
             .|:|::              ::.| :.|..::|..|.|....|..:...||.||:.||
  Fly    68 -QPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRT 131

  Fly   110 ------------------------ILDLSKNNI----------------TNITENNFRGQDN--- 131
                                    .||||.|||                .|.:.|..:...|
  Fly   132 HNGDWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYF 196

  Fly   132 ---------------LLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLK 181
                           |..||||.||::.:.::....|..|..||:|.||:..|..|.|..|..|:
  Fly   197 SASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLR 261

  Fly   182 YLDLSGNPLQDLQPDVFRDVPELKVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEF--KFLDKD 244
            .:|||.|.|..|.|::|.:..:|:.:..||..:..:.|.::..|..|..|||..||.  ::::..
  Fly   262 VVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAA 326

  Fly   245 EFRDVKRLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNK 309
            .|..:|||..:.|..|::|.:...:||...||..|.|..|.:.::|...|..||||..|.||.|:
  Fly   327 TFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNR 391

  Fly   310 LVRLEPQSIRSLSNLLTLNISGNVL--MDLREMRETFEPLIYYFFLTCSKL--------FFQLIP 364
            :..:|.::::.|.|||.|::..|.:  ||.|.:            :.||:|        ..|.:|
  Fly   392 ISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSL------------VNCSQLQDLHLNDNKLQAVP 444

  Fly   365 Q-LTHLAIADMGTMPVG----------LLHPFKQLRYLNISGNSLNNTALEVIDPCRELEFLDLS 418
            : |.|:.:  :.|:.||          .:...:.|..|.::.|||.:....|.|....|:.|:||
  Fly   445 EALAHVQL--LKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLS 507

  Fly   419 RNQLHGISEDTVLRIQGIRNVRLDNNPLICDECHMGKLINVVRQLQW------KWDTYPICFLPK 477
            :|:|..|...::.|...::.:|||.|.|    ..:..|...:..|.|      :.:.:....:|.
  Fly   508 QNKLKSIEAGSLQRNSQLQAIRLDGNQL----KSIAGLFTELPNLVWLNISGNRLEKFDYSHIPI 568

  Fly   478 SLRGAEINNLDINGLHTCLTFITDEEQNAASTSYNFL 514
            .|:..::....|..|.......::...:....|||.|
  Fly   569 GLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLL 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	11/68 (16%)
		LRR_8	131..190	CDD:290566	24/76 (32%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		LRR_RI	151..422	CDD:238064	87/293 (30%)
		leucine-rich repeat	156..179	CDD:275380	10/22 (45%)
		LRR_8	178..262	CDD:290566	26/85 (31%)
		leucine-rich repeat	180..203	CDD:275380	9/22 (41%)
		leucine-rich repeat	204..251	CDD:275380	12/48 (25%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		LRR_8	274..334	CDD:290566	22/59 (37%)
		leucine-rich repeat	276..299	CDD:275380	7/22 (32%)
		LRR_4	298..342	CDD:289563	17/45 (38%)
		leucine-rich repeat	300..323	CDD:275380	7/22 (32%)
		leucine-rich repeat	388..411	CDD:275380	7/22 (32%)
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	49/195 (25%)
		leucine-rich repeat	100..123	CDD:275380	8/22 (36%)
		leucine-rich repeat	124..144	CDD:275380	2/19 (11%)
		LRR_8	152..222	CDD:290566	16/69 (23%)
		leucine-rich repeat	154..177	CDD:275380	7/22 (32%)
		leucine-rich repeat	178..201	CDD:275380	3/22 (14%)
		LRR	210..656	CDD:227223	113/414 (27%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..259	CDD:275380	10/22 (45%)
		leucine-rich repeat	260..283	CDD:275380	9/22 (41%)
		LRR_RI	276..558	CDD:238064	79/299 (26%)
		leucine-rich repeat	284..307	CDD:275380	5/22 (23%)
		leucine-rich repeat	308..333	CDD:275380	7/24 (29%)
		leucine-rich repeat	334..357	CDD:275380	6/22 (27%)
		leucine-rich repeat	358..381	CDD:275380	7/22 (32%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..429	CDD:275380	8/34 (24%)
		leucine-rich repeat	430..452	CDD:275380	5/21 (24%)
		leucine-rich repeat	453..500	CDD:275380	10/46 (22%)
		leucine-rich repeat	501..521	CDD:275380	7/19 (37%)
		leucine-rich repeat	525..547	CDD:275380	6/25 (24%)
		leucine-rich repeat	548..573	CDD:275380	4/24 (17%)
		leucine-rich repeat	604..640	CDD:275380	1/2 (50%)
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453667
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740