DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and kek6

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	892	Identity:	170/892 - (19%)
Similarity:	280/892 - (31%)	Gaps:	340/892 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLLFSLCIMP-AMFSNTKRKCPTECQCSMDDLDRYQAICTKGGLNSLLSPNELDVDVKVIIIRGP 68
            |:|  ||::. .:..:....|.:.|.|...: .:..|||:...|.::  ||.|..:::|::
  Fly    20 WIL--LCLVAWTVADDWSLSCASNCTCKWTN-GKKSAICSSLQLTTI--PNTLSTELQVLV---- 75

  Fly    69 RNSITIGPALRQFMKLEILRITDSNLPAIGAESF--WGLKYLRILDLSKNNITNITENNFRGQDN 131
                                :.|:::|.:..|.|  .||..|:.:.|.|:.:..|.:.:||....
  Fly    76 --------------------LNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKI 120

  Fly   132 LLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFM-LSRLKYLDLSGNPLQDLQP 195
            |:|:|||.||                         :|::.::.|| ..||:.|.|:||||:.|..
  Fly   121 LVEIDLSDNK-------------------------LEMLDKDTFMGNDRLRILYLNGNPLKRLAA 160

  Fly   196 DVFRDVPELKVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGN 260
            ..|..:|.|:.|...:|.:..|:|.
  Fly   161 YQFPILPHLRTLDMHDCLISYIDPM---------------------------------------- 185

  Fly   261 QLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLL 325
                          ||.:|:|                  |.||:|..|.|..|.....:.::||.
  Fly   186 --------------SLANLNL------------------LEFLNLKNNLLESLSEYVFQHMANLK 218

  Fly   326 TLNISGNVLM---DLREMRETF-EPLIYYFFLTCSKLFFQLIPQLTHLAIAD--MGTMPVGLLHP 384
            ||::..|...   .||:.|..: ...:....|.|.....|  ...|..::.|  .|..|...:..
  Fly   219 TLSLEENPWQCNCKLRKFRGWYVNSRLSSVSLVCKGPPAQ--KDRTWDSVDDELFGCPPRVEIFN 281

  Fly   385 FKQLRYLNISGNSLNNTALEVIDPCRELEFLDLSRNQLHG--ISEDTVL-RIQGIRNVRLDNNPL 446
            .::::.::| |::...:.|...||..|:.:      :|:|  :..|.|| ..:.|.:.:|.:|
  Fly   282 NEEVQNIDI-GSNTTFSCLVYGDPLPEVAW------ELNGKILDNDNVLFESESIASDKLWSN-- 337

  Fly   447 ICDECHMGKLINVVRQLQWKWDTYPICFLPKSLRGAEINNLDINGLHTCLTFITDEEQNAASTSY 511
                      :.|.........|| .|....|: |:...|:.|        ::::..|:....:.
  Fly   338 ----------LTVFNVTSLDAGTY-ACTGSNSI-GSMTQNISI--------YLSEIVQHVLEKTP 382

  Fly   512 NFLEHGGLNTLAILG--GIIFVLIAVIILSLVACFSKNRARYYTRED--------HLNGSESKCL 566
            ....:.||    |:|  |.:|:||::   |.|.|..|...|.:...:        ..|..|.|.|
  Fly   383 ETFWYFGL----IMGIFGTVFLLISI---SFVVCLCKRTTRQHRHANKAGVKSSVSFNDQEKKLL 440

  Fly   567 EKNLEATTITTLGNGSSPTTTTTLTLATSPAAPNGPKTNG--QGLSLSPANGSTPVHGISDDK-- 627
            :               |..||||.....|....|.|.:.|  :|.|.........:|.:...:
  Fly   441 D---------------SSVTTTTNDRGDSYGIDNQPTSIGMNKGDSAGMGFNQIEIHAVESHRHG 490

  Fly   628 ----------------GKEINFTFPVDDRVC------------------TIDELMPSP----PPP 654
                            |........|.|..|                  .|.|..|..    |||
  Fly   491 SMLVQQQPQQQQVAGGGGMRQQLMQVKDSTCGMMSVPTSMAGHAHSHPAQISEEFPLNVGVFPPP 555

  Fly   655 PQ----QHPHPNMGSLMY---SVSHS----------------PNSATTLAAVAAAATVIPPG--- 693
            |:    ..|:|..|..::   ||:..                |.....:....|.|..:|.|
  Fly   556 PEFCSNIVPNPAFGGNIFIRVSVTQDMLDGADLNMYPDLLNIPKRMQDVQESGAGAVAVPEGQFA 620

  Fly   694 -APSHSS---------------------------------------------MPTPTPTPAEAV- 711
             .|.|::                                             .|:...|..|.|
  Fly   621 TLPRHTARRGILKKDTSLQQQQQQHQQQHQHQQQQQQQQIQQQQHQQLQQQHQPSGLYTHDEIVT 685

  Fly   712 ------------------VVVLPPPPLPPQ-----QHHHQMDGSLAS 735
                              .:.|||||.||.     |.||....:.||
  Fly   686 YNLEASGYDPHQSGYHSNAMELPPPPPPPAVTAVVQCHHPSPNNCAS 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	6/24 (25%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		LRR_8	131..190	CDD:290566	16/59 (27%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		LRR_RI	151..422	CDD:238064	51/277 (18%)
		leucine-rich repeat	156..179	CDD:275380	3/23 (13%)
		LRR_8	178..262	CDD:290566	16/83 (19%)
		leucine-rich repeat	180..203	CDD:275380	9/22 (41%)
		leucine-rich repeat	204..251	CDD:275380	5/46 (11%)
		leucine-rich repeat	252..275	CDD:275380	0/22 (0%)
		LRR_8	274..334	CDD:290566	16/59 (27%)
		leucine-rich repeat	276..299	CDD:275380	3/22 (14%)
		LRR_4	298..342	CDD:289563	14/46 (30%)
		leucine-rich repeat	300..323	CDD:275380	7/22 (32%)
		leucine-rich repeat	388..411	CDD:275380	5/22 (23%)
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	7/48 (15%)
		LRR_8	96..155	CDD:290566	22/83 (27%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	10/47 (21%)
		LRR_4	144..186	CDD:289563	16/95 (17%)
		leucine-rich repeat	145..168	CDD:275380	9/22 (41%)
		leucine-rich repeat	169..216	CDD:275380	16/118 (14%)
		LRRCT	225..274	CDD:214507	10/50 (20%)
		Ig	295..367	CDD:143165	19/91 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453728
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030