DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdo and cDIP

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	382	Identity:	94/382 - (24%)
Similarity:	172/382 - (45%)	Gaps:	67/382 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LRQFMKLEILRITDSNLPAIGAE-SFW-----GLKYLRILDLSKNNITNITENNFRGQDNLLELD 136
            ||.|..||   :::.::...|.. .:|     |...|.||.||.|:|..:....|||..||..:.
  Fly   110 LRLFYTLE---VSELDMRGCGIRFIYWENFSIGADKLVILLLSDNHIEVLPTKTFRGAGNLEFIF 171

  Fly   137 LSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPDVFRDV 201
            |::||:.::.:..|.:|..|:.|:|.:|.:..|....|..|..|:::.|:||.|..::.|:|...
  Fly   172 LNRNKLGKLQAGAFDNLLKLQYLDLTENRLEALAADVFAGLKSLRHVGLAGNQLTTIESDLFAHN 236

  Fly   202 PELKVLKCRNCQLKKINPQMYNLLPLLSELDLGR-NEFKFLDKDEFRDVKRLTKVLLDGNQLSVV 265
            |:|..:..:|.:|:::....:.        ..|| ::.:::|   ..:...|..:||:.|..::.
  Fly   237 PDLLSVAMQNNRLREVGEYAFR--------SRGRHHQMQYVD---LSNNPELVVLLLNINATNLT 290

  Fly   266 -----VDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLL 325
                 :|:: .:..|:.::|||.||:.::   .|.....|..|.|..|.||:|  .|:..:..|.
  Fly   291 ARNCSLDRV-NLYGSVTNVDLSDNRVREL---YFPASEALEHLVLRNNSLVQL--ASLSRVPRLR 349

  Fly   326 TLNISGNVLMDLREMRETFEPLIYYFFLTCSKLFFQLIPQLTHLAIADMGTM--PVGLLHPFKQL 388
            .|:::.|  .:|.::.:.:.                 .|.|..|.:.:.|.|  |:..|...:.|
  Fly   350 HLDVADN--PNLGQLPDGWR-----------------TPHLEMLVLRNTGQMELPLEALQGMQNL 395

  Fly   389 RYLNISGNSLNNTALEVIDPCRELEFLDLSRNQLHGIS---------EDTVLRIQGI 436
            :.|:||||:|..     |||........|:...:||.:         .|.::|..||
  Fly   396 QKLDISGNNLTE-----IDPSAFPTLTQLTHFYIHGNNWNCFSLRNIMDVLIRANGI 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	5/28 (18%)
		leucine-rich repeat	108..131	CDD:275380	10/22 (45%)
		LRR_8	131..190	CDD:290566	18/58 (31%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		LRR_RI	151..422	CDD:238064	64/278 (23%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		LRR_8	178..262	CDD:290566	18/84 (21%)
		leucine-rich repeat	180..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..251	CDD:275380	6/47 (13%)
		leucine-rich repeat	252..275	CDD:275380	5/27 (19%)
		LRR_8	274..334	CDD:290566	18/59 (31%)
		leucine-rich repeat	276..299	CDD:275380	6/22 (27%)
		LRR_4	298..342	CDD:289563	12/43 (28%)
		leucine-rich repeat	300..323	CDD:275380	8/22 (36%)
		leucine-rich repeat	388..411	CDD:275380	10/22 (45%)
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	3/23 (13%)
		LRR_RI	143..407	CDD:238064	76/299 (25%)
		leucine-rich repeat	143..166	CDD:275380	10/22 (45%)
		LRR_8	166..225	CDD:290566	18/58 (31%)
		leucine-rich repeat	167..190	CDD:275380	6/22 (27%)
		leucine-rich repeat	191..214	CDD:275380	7/22 (32%)
		leucine-rich repeat	215..238	CDD:275380	7/22 (32%)
		leucine-rich repeat	239..265	CDD:275380	5/33 (15%)
		leucine-rich repeat	266..325	CDD:275380	13/65 (20%)
		LRR_8	304..357	CDD:290566	18/59 (31%)
		leucine-rich repeat	326..347	CDD:275380	8/22 (36%)
		leucine-rich repeat	348..394	CDD:275380	11/64 (17%)
		LRR_8	369..428	CDD:290566	20/63 (32%)
		LRR_4	393..433	CDD:289563	13/44 (30%)
		leucine-rich repeat	395..418	CDD:275380	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840