DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and CG18249

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001163549.1	Gene:	CG18249 / 40964	FlyBaseID:	FBgn0037553	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	649	Identity:	146/649 - (22%)
Similarity:	243/649 - (37%)	Gaps:	177/649 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FKWLLFSLCIMP-----AMFS-----NTKRKCPTECQCSMDDLD-RYQAI------------CTK 44
            :|::|..:|.:.     |::.     |....|| :..||:.|.. .|.|.            |::
  Fly     4 YKYILLGICGLTVSDALAVYDASGRFNLSASCP-DSFCSLSDRPVAYSATPALQLRELHLRNCSR 67

  Fly    45 GGLNSLLSPNELDVDVKVIIIRGPRNSITIGPALRQFMKLEILRITDSNLPAIGAESFWGLKYLR 109
            ..:..|:.  :|...::.::||..........:||....|..|::..::|..:..:.|..:..|.
  Fly    68 QSITWLVL--QLTPGLRTLVIRNCATYHISKESLRPVENLTSLQMQGTSLGVLRDQIFNAVPRLE 130

  Fly   110 ILDLSKNNITNITENNFRGQDNLLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNF 174
            ||.||:|.|..:....|:|...|..|.|..|.:..:.|||...|.:|..|:|:.|.:..|.|..|
  Fly   131 ILQLSQNFIHTVHVAAFQGLSKLRLLGLQGNAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIF 195

  Fly   175 FMLSRLKYLDLSGNPLQDLQPDVFRDVPELKVLKCRN-CQLKKINPQMYNLLPLLSE-------- 230
            ....:|:.|.|:||||:.|.|||...:|.|::|...: .:|:.:...:.|:..|:.|
  Fly   196 AKNKKLQTLLLNGNPLRILMPDVLGSLPNLRLLDLGHAAELEVMTLNLTNVQNLVLEGSSLSSLV 260

  Fly   231 -------LDLGRNEFKFLDKDEFRDV--KRLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRL 286
                   |..|.||...|.......|  ..|...||:||..:.::..::.:|:    ||||.||:
  Fly   261 INGGFIKLQAGNNELNHLQVGNKSSVIEMDLHGNLLNGNDTAALLRGMWNLQR----LDLSKNRI 321

  Fly   287 AKVP----------NDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVLMDLREMR 341
            ..:|          ....|.|.:|.||:|:.|:||||.|:|....|.|..|::|.|:::
  Fly   322 EALPQHGSGLDASGTQELLILPSLKFLNLANNQLVRLPPESPILSSRLSYLDLSHNLML------ 380

  Fly   342 ETFEPLIYYFFLTCSKLFFQLIPQLTHLAIADMGTMPVGLLHPFKQLRYLNISGNSLNNTALEVI 406
                                              |:.|.:|.....|:.|.:.||.||....:.:
  Fly   381 ----------------------------------TLDVAILRSLSVLKGLYVEGNRLNTINYQKL 411

  Fly   407 DPCRELEFLDLSRNQLH------GISEDTVLRIQGIRNVRLDNNPLICDECHMGKLINVVRQLQW 465
            ..    |..|||...||      |:.....|.... |.|.|...|       ..:::|...::..
  Fly   412 HE----EHPDLSELGLHDNPWSSGLYRKMFLYFTD-RGVHLQARP-------QNRVLNKSSRVDI 464

  Fly   466 KWDTYPICFLPKSLRGAEINNLD---INGLH------TCLTFITDEEQNAASTSYNFLEHGGLNT 521
            .|        |.:...||...:|   :.|:|      ..|.|:|
  Fly   465 DW--------PPNEGQAEAQKMDPPGVTGIHPYWTLRDILAFVT--------------------- 500

  Fly   522 LAILGGIIFVLIAVIILSLVACFSKNRARYYTREDHLNGSESKCLEKNLEATTITTLGNGSSPT 585
                   :.|::.:::::|          |:..|      |..||.:........|||..:|.|
  Fly   501 -------LLVVMIILLMNL----------YHILE------EEGCLRRFRHWRRSRTLGQNTSTT 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	4/22 (18%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_8	131..190	CDD:290566	20/58 (34%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		LRR_RI	151..422	CDD:238064	76/298 (26%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		LRR_8	178..262	CDD:290566	29/101 (29%)
		leucine-rich repeat	180..203	CDD:275380	11/22 (50%)
		leucine-rich repeat	204..251	CDD:275380	12/64 (19%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		LRR_8	274..334	CDD:290566	25/69 (36%)
		leucine-rich repeat	276..299	CDD:275380	9/32 (28%)
		LRR_4	298..342	CDD:289563	16/43 (37%)
		leucine-rich repeat	300..323	CDD:275380	11/22 (50%)
		leucine-rich repeat	388..411	CDD:275380	6/22 (27%)
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	3/24 (13%)
		LRR_8	104..163	CDD:290566	17/58 (29%)
		leucine-rich repeat	105..128	CDD:275380	4/22 (18%)
		LRR_RI	107..438	CDD:238064	98/378 (26%)
		leucine-rich repeat	129..152	CDD:275380	9/22 (41%)
		leucine-rich repeat	153..176	CDD:275380	8/22 (36%)
		LRR_8	176..232	CDD:290566	21/55 (38%)
		leucine-rich repeat	177..200	CDD:275380	7/22 (32%)
		leucine-rich repeat	201..224	CDD:275380	11/22 (50%)
		leucine-rich repeat	225..258	CDD:275380	6/32 (19%)
		leucine-rich repeat	259..310	CDD:275380	11/50 (22%)
		leucine-rich repeat	311..344	CDD:275380	10/36 (28%)
		LRR_8	343..403	CDD:290566	23/99 (23%)
		leucine-rich repeat	345..368	CDD:275380	11/22 (50%)
		leucine-rich repeat	369..390	CDD:275380	7/60 (12%)
		leucine-rich repeat	393..417	CDD:275380	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453826
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840