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Protein Alignment rdo and CD180

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_005573.2	Gene:	CD180 / 4064	HGNCID:	6726	Length:	661	Species:	Homo sapiens

Alignment Length:	671	Identity:	135/671 - (20%)
Similarity:	255/671 - (38%)	Gaps:	191/671 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KWLLFSLCIMPAMFSNTKRKCP-------TECQCSMDDLDRYQAICTKGGLNSL-LSPNELDVDV 60
            ::|.||...:|.:.:.|..:..       |.||.:....|.:|   :...|::| |:.|.| :.:
Human    56 EFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQ---SHHQLSTLVLTGNPL-IFM 116

  Fly    61 KVIIIRGPRN-----SITIGPALRQFM------KLEILRITDSNLPAIGAESFWGLKYLRILDLS 114
            ....:.||::     .|..|.:..:|:      .||.|.:..:::.:|.....:..:.|::||..
Human   117 AETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQ 181

  Fly   115 KNNITNITENNFRGQDNLLELDLSKN----KVLRMAS---------------------------- 147
            .|.|..|:..:.|..:..:.|.|:.|    |.:.:.:
Human   182 NNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNST 246

  Fly   148 ------STFRHLTD---------------LRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQ 191
                  .||..:.|               :..|||.::...::....|...::|:.|||:...|:
Human   247 TQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLK 311

  Fly   192 DLQPDVFRDVPELK--VLKCRN----CQLKKIN-PQMYNL------------------LPLLSEL 231
            .| |...:.:..||  ||...:    ||:...| |.:.:|                  |..|..|
Human   312 GL-PSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTL 375

  Fly   232 DLGRNEFKFLD--KDEFRDVKRLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRL------AK 288
            ||..|:.:..|  ..:.:::..|..:.|..|:...:..|.|:....|..|||::.||      :.
Human   376 DLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSP 440

  Fly   289 VPNDSFLQLTNLT--FLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVLMDLREMRETFEPLIYYF 351
            ..|..|||:.|||  |||.|...|       :..|..|..||:.||...|
Human   441 FQNLHFLQVLNLTYCFLDTSNQHL-------LAGLPVLRHLNLKGNHFQD--------------- 483

  Fly   352 FLTCSKL-FFQLIPQLTHLAIADMGTMPVG--LLHPFKQLRYLNISGNSLNNTALEVIDPCRELE 413
             .|.:|. ..|.:..|..|.::..|.:.:.  ..|...::.::::|.|||...:::.:...:.:
Human   484 -GTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI- 546

  Fly   414 FLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPL--ICDECHMGKLINVVRQLQW-KWDTYPI--- 472
            :|:|:.|.::.||...:..:.....:.|.:|||  .|...|.         |.| |.:.:.:
Human   547 YLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHF---------LTWYKENLHKLEGS 602

  Fly   473 ----CFLPKSLRGAEINNLDINGLHTCLTFITDEEQNAASTSYNFLEHGGLNTLAILGGIIFVLI 533
                |..|.||||.:::::.:    :|                      |:..:    ||.|:::
Human   603 EETTCANPPSLRGVKLSDVKL----SC----------------------GITAI----GIFFLIV 637

  Fly   534 AVIILSLVACFSKNRARYYTR 554
            .:::|:::..|:   .:|..|
Human   638 FLLLLAILLFFA---VKYLLR 655

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.