DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and tlr20.2

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001170914.2	Gene:	tlr20.2 / 403140	ZFINID:	ZDB-GENE-040220-6	Length:	950	Species:	Danio rerio

Alignment Length:	615	Identity:	132/615 - (21%)
Similarity:	232/615 - (37%)	Gaps:	180/615 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SNTKRKCPTECQCSMD---DLDRYQA------ICTKGGLNSLLSPNELDVDVKVIIIRGPRNSIT 73
            |:.:::..|.|:...|   ||....|      :.|..|.:.:|:||
Zfish    47 SSPRKRNTTVCRSVTDMKEDLRGLPANLQNLIVQTDLGYHGVLAPN------------------- 92

  Fly    74 IGPALRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLELDLS 138
               :..:|..||.|.|... |..:..|:|             |.:||:|           .|.||
Zfish    93 ---SFLRFGSLENLEIVGC-LSEVPPEAF-------------NGLTNVT-----------TLTLS 129

  Fly   139 KNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPDVFR--DV 201
            .::.....:..|..||.|..|:|:|.|:..|....|..:.:|::|.|....|:||...:.|  :|
Zfish   130 CSQQCTEVAFDFSRLTSLTSLSLSDYSLSLLPSNVFEKIPQLRWLHLCSECLKDLSEVLCRLKNV 194

  Fly   202 PELKVLKCRNCQLKKI---NPQMYN---------------LLPLLSELD---------LGRNEFK 239
            ..||.|...|..|.::   |..::|               ||..|..:|         |.|..|.
Zfish   195 KSLKYLGLGNTMLTRLQYPNCSVFNVSEISTKFNIERADLLLGKLEHVDEGALKVFGKLSRLYFT 259

  Fly   240 FLDKDEFRDVKRLTKVLLDGNQLSVV--------VDQLFRMQK--SLNHLDLSYNRL-----AKV 289
            ...|:..||:.     |:..:|:||:        ||.|....|  |:..:|:.|:.:     :|:
Zfish   260 VSSKNFLRDLS-----LIGVHQISVIIATVDVLNVDDLCVAAKLYSVKSVDVDYDTINLSLTSKI 319

  Fly   290 PNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSL----SNLLTLNISGNVLMDLREMRETFEPLIYY 350
             :|...|:..:...:..:.|.|.|  ..:.||    |||.::.|..:||..     ..|:.|...
Zfish   320 -SDGCKQIGYIMLENNIFGKTVNL--LDVNSLFQIFSNLTSVTIDKHVLRS-----NDFQSLCAS 376

  Fly   351 FFLTCSKL------FFQLIPQLTH--LAIADMGTMPVGL-----LHPF-----KQLRYLNISGNS 397
            |..|..|:      ..::...::|  :...::.|:.:.:     :..|     .:|:.||:..|.
Zfish   377 FPQTVKKISDMVLRIIRIDKIVSHQFMCFVNLKTLKLAMSKFSVIEDFAFIGLNKLKELNLHSNK 441

  Fly   398 LNNTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRL------DNNPLICDECHMGKL 456
            :::..........||..|||:.|.|..|..::...:..:|.:.|      .|..||  :.|   |
Zfish   442 ISSIHQHTFSGLHELRVLDLNENPLFHIEPESFRHLINLRTLLLGDLNFPPNMSLI--KLH---L 501

  Fly   457 INVVRQLQWKWDTYPICFLPKSLRGAEINNLDINGLHTCLTFITDEEQNAASTSYNFLEHGGLNT 521
            .::.|:            :|::|....|:: .:..:|..:         .::|:.|    .|||
Zfish   502 SDIFRE------------IPRNLSNVFISS-GLRPMHLVI---------GSNTTLN----NGLN- 539

  Fly   522 LAILGGIIFV-------LIAVIILSLVACF 544
            |.|.|..:.|       |.:|:.|.:.|.:
Zfish   540 LHIKGQYVIVEDCNSLLLTSVVTLQINAAY 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	7/22 (32%)
		leucine-rich repeat	108..131	CDD:275380	4/22 (18%)
		LRR_8	131..190	CDD:290566	16/58 (28%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		LRR_RI	151..422	CDD:238064	77/336 (23%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		LRR_8	178..262	CDD:290566	26/112 (23%)
		leucine-rich repeat	180..203	CDD:275380	8/24 (33%)
		leucine-rich repeat	204..251	CDD:275380	17/73 (23%)
		leucine-rich repeat	252..275	CDD:275380	8/32 (25%)
		LRR_8	274..334	CDD:290566	16/70 (23%)
		leucine-rich repeat	276..299	CDD:275380	5/27 (19%)
		LRR_4	298..342	CDD:289563	11/47 (23%)
		leucine-rich repeat	300..323	CDD:275380	5/26 (19%)
		leucine-rich repeat	388..411	CDD:275380	4/22 (18%)
tlr20.2	NP_001170914.2	leucine-rich repeat	358..383	CDD:275380	7/29 (24%)
		LRR_8	407..466	CDD:290566	12/58 (21%)
		leucine-rich repeat	408..431	CDD:275380	2/22 (9%)
		LRR_4	431..471	CDD:289563	12/39 (31%)
		leucine-rich repeat	432..455	CDD:275380	4/22 (18%)
		leucine-rich repeat	456..479	CDD:275380	7/22 (32%)
		leucine-rich repeat	496..539	CDD:275380	12/73 (16%)
		leucine-rich repeat	540..583	CDD:275380	8/30 (27%)
		leucine-rich repeat	584..608	CDD:275380
		leucine-rich repeat	609..634	CDD:275380
		leucine-rich repeat	635..658	CDD:275380
		TIR	802..940	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900