DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and tlr19.1

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001352353.1	Gene:	tlr19.1 / 403134	ZFINID:	ZDB-GENE-040220-3	Length:	958	Species:	Danio rerio

Alignment Length:	552	Identity:	127/552 - (23%)
Similarity:	205/552 - (37%)	Gaps:	159/552 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 AICTKGGLNSLLSPNELDVDVKVIIIRGPRNSITIGPALRQFMKLEILRITDSNLPAIGAESFWG 104
            |.|....|::.||  ::..:|:.:.:.|...||. ..|......||:|.|....|..:.|.:|.|
Zfish    62 ANCNITDLSTDLS--QVGFEVRTLCVFGDITSIP-AKAFSHLPSLEVLHIDGIRLERVQAGAFEG 123

  Fly   105 LKYLRILDLSKNN----ITNITENNFRGQDNLLELDLSKNKVLRMASSTF--------------- 150
            |..|:.|.:..::    :..|...:|.|.:||.||.|:...:|..:|..|
Zfish   124 LPNLKYLSMLFSDELYRLVRIDNRSFAGLNNLEELSLTGLMLLNGSSGIFDPLVSLIRLDIVRTC 188

  Fly   151 ------------RHLTDLRRLNLADNSIVELVQRN---------FFMLSRLKYLDLSGNPLQDLQ 194
                        ..:|.||.||:.|:.|..:..:.         ...||.::.|.|.||.::.:|
Zfish   189 AQDLGEIFCCISNGMTRLRHLNVEDSEISTIENKGCPGGSMTWPLTALSGVQNLYLIGNNIKYIQ 253

  Fly   195 PD---VFRDVPEL------------------KV--LKCRNCQLKKINPQMYNLLPLLS-----EL 231
            .:   :|:::..|                  ||  |..:...|||.:....:|..|:|     .|
Zfish   254 ANSLIIFQNLSSLFLEFEGKSLGSIWESGVGKVNDLTLKGKVLKKYSTNFKDLCHLVSSLYSQSL 318

  Fly   232 DLGRNEFKFLDKDEFRDV-KRLTKVLLDGNQLSVVVDQL-FR-------MQK------------- 274
            .|.......|..::.:|. .:|||:|:..::    :|.| ||       ||.
Zfish   319 SLVYTSIDRLTAEDLKDCGTKLTKLLIQNSK----IDNLDFRFWTSKLEMQALQMAYMKLTDAPF 379

  Fly   275 ---------SLNHLDLSYNRLAKVPNDSF------------------LQ------LTNLTFLDLS 306
                     ||..|||:.|.:..:..|.|                  ||      |..|..|.|.
Zfish   380 CFVANSTMWSLTSLDLTGNSITNIEGDQFACMPFLEQLYLSQNAIKTLQLHAFRGLPRLKILQLD 444

  Fly   307 YNKLVRLEPQSIRSLSNLLTLNISGNVL--------MDLREMRE-TFEPLIYYFFLTCSKLFFQL 362
            .||:.:|.....::|..|..|.|:.|::        .|.||:.| :|..|.|.:.|....:||:.
Zfish   445 SNKIWQLSANDFKNLRALEVLLINDNIIETIETGTFWDQRELCELSFGRLEYVYELHLENIFFEF 509

  Fly   363 IPQLTHLAI-ADMGT-MPVGLLHPFKQLRYLNISGNSLNNTAL--EVIDPCRELE---------- 413
            .|:|..|:| |..|| :.:|...|......|.::|..|.....  :|:...|||:
Zfish   510 PPKLQRLSIDAHYGTNIYIGNASPPNGTFALELNGERLGFVGCDSDVLMAVRELKVNCTYFLCKD 574

  Fly   414 ------FLDLSRNQLHGISEDTVLRIQGIRNV 439
                  ||:|...::.|.:|...|....|.|:
Zfish   575 SFMAPYFLNLESLEISGGAERAPLNYATINNL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	9/22 (41%)
		leucine-rich repeat	108..131	CDD:275380	5/26 (19%)
		LRR_8	131..190	CDD:290566	21/94 (22%)
		leucine-rich repeat	132..155	CDD:275380	7/49 (14%)
		LRR_RI	151..422	CDD:238064	90/391 (23%)
		leucine-rich repeat	156..179	CDD:275380	7/31 (23%)
		LRR_8	178..262	CDD:290566	25/112 (22%)
		leucine-rich repeat	180..203	CDD:275380	6/25 (24%)
		leucine-rich repeat	204..251	CDD:275380	14/72 (19%)
		leucine-rich repeat	252..275	CDD:275380	10/52 (19%)
		LRR_8	274..334	CDD:290566	22/105 (21%)
		leucine-rich repeat	276..299	CDD:275380	10/46 (22%)
		LRR_4	298..342	CDD:289563	14/51 (27%)
		leucine-rich repeat	300..323	CDD:275380	7/22 (32%)
		leucine-rich repeat	388..411	CDD:275380	4/24 (17%)
tlr19.1	NP_001352353.1	LRR_8	101..162	CDD:316378	19/60 (32%)
		leucine-rich repeat	103..126	CDD:275380	9/22 (41%)
		leucine-rich repeat	127..154	CDD:275380	5/26 (19%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..238	CDD:275380	8/58 (14%)
		leucine-rich repeat	207..219	CDD:275378	5/11 (45%)
		leucine-rich repeat	239..265	CDD:275380	6/25 (24%)
		leucine-rich repeat	340..363	CDD:275380	8/26 (31%)
		leucine-rich repeat	364..389	CDD:275380	2/24 (8%)
		LRR_8	389..448	CDD:316378	15/58 (26%)
		leucine-rich repeat	390..413	CDD:275378	7/22 (32%)
		leucine-rich repeat	414..437	CDD:275378	3/22 (14%)
		LRR_8	436..>482	CDD:316378	11/45 (24%)
		leucine-rich repeat	438..461	CDD:275378	7/22 (32%)
		leucine-rich repeat	462..485	CDD:275378	5/22 (23%)
		leucine-rich repeat	540..562	CDD:275380	4/21 (19%)
		leucine-rich repeat	563..608	CDD:275380	9/44 (20%)
		leucine-rich repeat	609..634	CDD:275380
		leucine-rich repeat	635..658	CDD:275380
		TIR	809..952	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900