DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and tlr18

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001082819.1	Gene:	tlr18 / 403133	ZFINID:	ZDB-GENE-040220-2	Length:	854	Species:	Danio rerio

Alignment Length:	638	Identity:	123/638 - (19%)
Similarity:	231/638 - (36%)	Gaps:	209/638 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 LEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLELDLSKN-------- 140
            ||.|.::.:.:..|..:.|..|.|||:|.|:.|||:.:.::.|:|...|.||:|..|
Zfish    54 LEELDLSFNTIHVIRKQDFVKLTYLRVLKLNFNNISLVLDDAFQGNLLLEELNLFNNSLTEIPFK 118

  Fly   141 --------KVLRMAS---------STFRHLTDLRRLNLADNSIVELVQRNFFMLSRL---KYLDL 185
                    |||.|::         :.|.:...|:.|::....:..|..|:.::|..:   |:...
Zfish   119 ALEPLTNLKVLEMSNNLYSQASLGAAFLNFNQLKVLSIGGPLVSSLGSRDIYVLKNISLDKFAVK 183

  Fly   186 SGNPLQDLQPDVFRDV--------------PEL-------------KVLKCRNC----------- 212
            :|...:|.:|..|:.:              |:|             .||:.||.
Zfish   184 TGTGFRDYEPGYFKSLSTKHLWFDIAFDKNPDLLPKMLKDLANKTFDVLRFRNLFEFQYYTGKRD 248

  Fly   213 ---QLKKINPQMYNLLPLLSELDLGRNEFK------FLDKDEFRDVKRLTKVLLD---------G 259
               .|:.:|.|         .|...|.:|.      .|...|...:|.|..:|:|         |
Zfish   249 IFYGLQYVNAQ---------TLTFYRGKFNEEVMRMALKNVEISPIKALELLLIDFARSQNRTQG 304

  Fly   260 NQL-SVVVDQLFRMQKS-------------LNHL------DLSYNRLAKVPNDSFLQLTNLTFLD 304
            :.: ::.:|:|.....|             |||:      ::::|   .||.||:.::.::..||
Zfish   305 SSVKNLSLDRLVLSDISNPDIMRFDWSFTWLNHVRKFIVWNVNFN---SVPCDSWPEMKSVELLD 366

  Fly   305 LSYNKLVR---LEP--QSIRSLSNLLTLNISGNVLMDLREMRETFEPLIYYFFLTCSKLFFQLIP 364
            :|.|:|:.   ..|  .:..:|..|.|.|:|.|.|..|.::            .:.:|.|.:|..
Zfish   367 ISNNQLLDSYIYNPLCDTRNTLHKLDTFNVSHNRLTSLSDL------------ASLTKDFVKLTT 419

  Fly   365 -QLTHLAIADMG----------TMPVG-----LLHPFK----QLRYLNISGNSLNNTALEVIDPC 409
             .::|..:..:|          |..:|     ....||    .:.:|::|.:||:...::..:..
Zfish   420 IDMSHNQLQYLGNGACDWRKTITKVIGNHNSLTSDSFKCLPTSVNFLDLSYSSLDQLDMDYFNKA 484

  Fly   410 RELEFLDLSRNQLHGISED------TVLRIQG----------------IRNVRLDNNPLICDECH 452
            .||..|.||.|::..|...      ..|.:.|                :|.:...|||..| .|
Zfish   485 SELTELLLSGNKIKFIPSGWKNRYLRTLALDGNSFGLVSMKSFKDMLSLRVLTAGNNPYHC-TC- 547

  Fly   453 MGKLINVVRQLQWK-------WDTYPICFLPKSLRGAEINNLDINGLHTCLTFITDEEQNAASTS 510
              .|...:::...|       |.....|:.|:.|....::......|...:|.:.
Zfish   548 --DLYTFIQETTSKGKVTITDWPNNYKCYHPERLLNTMVSKYSPGHLACDITLVI---------- 600

  Fly   511 YNFLEHGGLNTLAILGGIIFVLIAVIILSLVACFSKN-----RARYYTREDHL 558
                    :.:::....::.|::.:..:..|..:.|.     ||:|...::.|
Zfish   601 --------IISVSTTAAVVLVIMLLCYIFHVPWYVKATYQIIRAKYRAHKEGL 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	6/22 (27%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_8	131..190	CDD:290566	17/86 (20%)
		leucine-rich repeat	132..155	CDD:275380	10/47 (21%)
		LRR_RI	151..422	CDD:238064	73/374 (20%)
		leucine-rich repeat	156..179	CDD:275380	5/22 (23%)
		LRR_8	178..262	CDD:290566	24/142 (17%)
		leucine-rich repeat	180..203	CDD:275380	5/39 (13%)
		leucine-rich repeat	204..251	CDD:275380	13/79 (16%)
		leucine-rich repeat	252..275	CDD:275380	6/32 (19%)
		LRR_8	274..334	CDD:290566	21/83 (25%)
		leucine-rich repeat	276..299	CDD:275380	8/28 (29%)
		LRR_4	298..342	CDD:289563	14/48 (29%)
		leucine-rich repeat	300..323	CDD:275380	7/27 (26%)
		leucine-rich repeat	388..411	CDD:275380	4/22 (18%)
tlr18	NP_001082819.1	LRR_8	53..>98	CDD:316378	15/43 (35%)
		leucine-rich repeat	54..77	CDD:275380	6/22 (27%)
		leucine-rich repeat	78..101	CDD:275380	9/22 (41%)
		leucine-rich repeat	102..125	CDD:275380	5/22 (23%)
		leucine-rich repeat	126..150	CDD:275380	5/23 (22%)
		LRR	<345..>519	CDD:227223	41/188 (22%)
		leucine-rich repeat	362..390	CDD:275380	7/27 (26%)
		leucine-rich repeat	391..416	CDD:275380	9/36 (25%)
		leucine-rich repeat	417..440	CDD:275380	3/22 (14%)
		leucine-rich repeat	441..462	CDD:275380	4/20 (20%)
		leucine-rich repeat	463..486	CDD:275380	4/22 (18%)
		leucine-rich repeat	487..508	CDD:275380	6/20 (30%)
		leucine-rich repeat	509..532	CDD:275380	2/22 (9%)
		TIR	653..791	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900