DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdo and tlr9

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001124066.1	Gene:	tlr9 / 403128	ZFINID:	ZDB-GENE-040219-10	Length:	1057	Species:	Danio rerio

Alignment Length:	600	Identity:	132/600 - (22%)
Similarity:	208/600 - (34%)	Gaps:	212/600 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 CQCSMDDLDRYQAICTKGGLNSLLSPNELDVDVKVIIIRGPRNSITIGPALRQFMKL---EILRI 89
            |..|:|            ||:.|.:...:|:...::......::.| ..|..|..:.   |...:
Zfish   398 CDISID------------GLSQLRTLRRVDLSQNMLAFSSCFSTCT-SEAEHQIPERYGNEQFNL 449

  Fly    90 TDSNLPAIGAE-------------SFWGLK--------YLRILDLSKNNITNITENNFRGQDNLL 133
            ....||.:.||             |.|..|        |   .|||:|||..:..:.|||.|.:.
Zfish   450 QMQELPILNAETQGSKPDYCSFYFSMWHFKRQICSKSLY---FDLSQNNIPWLNASTFRGMDRVA 511

  Fly   134 ELDLSKNKVLR-MASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPD- 196
            .:|||.|.:.: :....|.||:.|..||:|.|.|                         ||..|
Zfish   512 CVDLSYNYISQTLNGHQFSHLSKLSYLNMAYNRI-------------------------DLYSDK 551

  Fly   197 VFRDVPELKVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEFKFLDK---DEFRDVKRLTKVL-- 256
            .|::|.                       ..|..|||..|||.|:.|   .:|..:..::.::
Zfish   552 AFQEVS-----------------------GTLKALDLSNNEFHFIMKGMGHQFTFLTHMSSLIIL 593

  Fly   257 -LDGNQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDS--------FLQLTNLTFLDLSYNKLVR 312
             |..|.:.:.:..:. ...||.:|..|.||| .:..||        |..|||||.||:|.|:|..
Zfish   594 SLANNHIGLRISNIL-TSASLKYLIFSGNRL-DILWDSWRNQYINLFQGLTNLTHLDISENQLKS 656

  Fly   313 LEPQSIRSLSNLLTLNISGNVLMDLREMRETFEPLIYYFFLTCSKLFFQLIPQLTHLAIADMGTM 377
            |.|:.|            .|:.:.|:.:|..|..|.|:.:...|.|
Zfish   657 LSPEVI------------VNLPLSLQVLRVDFNMLTYFPWANISVL------------------- 690

  Fly   378 PVGLLHPFKQLRYLNISGNSLN---NTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNV 439
                    ::|.|||:|.|.|:   |...|:     .|..||||.|:|..|.:..:.:...::|:
Zfish   691 --------QKLCYLNLSSNMLSYLPNINFEL-----RLTGLDLSHNRLVAIPKVFLSQAANLKNL 742

  Fly   440 RLDN---------------------------------------NPLICDECHMGKLINVVRQLQW 465
            .|:|                                       ||..| .|.:......:|:...
Zfish   743 NLNNNQLKILDVQALPLPFHKGCTFIPGGQHKNRSSCKLVLHANPFTC-SCVISGFAKFLRETDL 806

  Fly   466 ---KWDTYPICFLPKSLRGAEINNLDINGLHTC------LTFITDEEQNAASTSYNFLEHGGLNT 521
               ...|...|..|:||.|..:.::|   |.:|      :.|:.......|:|....|:|
Zfish   807 DVPHLTTQVHCGFPESLAGVNVLSVD---LRSCQEIFGGVAFLCTSLLTLAATCVPLLKH----- 863

  Fly   522 LAILGGIIFVLIAVI 536
              :.|..::.||.::
Zfish   864 --LYGWDLWYLIQIL 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	8/46 (17%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_8	131..190	CDD:290566	13/59 (22%)
		leucine-rich repeat	132..155	CDD:275380	7/23 (30%)
		LRR_RI	151..422	CDD:238064	71/288 (25%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		LRR_8	178..262	CDD:290566	17/90 (19%)
		leucine-rich repeat	180..203	CDD:275380	5/23 (22%)
		leucine-rich repeat	204..251	CDD:275380	10/49 (20%)
		leucine-rich repeat	252..275	CDD:275380	2/25 (8%)
		LRR_8	274..334	CDD:290566	24/67 (36%)
		leucine-rich repeat	276..299	CDD:275380	10/30 (33%)
		LRR_4	298..342	CDD:289563	14/43 (33%)
		leucine-rich repeat	300..323	CDD:275380	10/22 (45%)
		leucine-rich repeat	388..411	CDD:275380	9/25 (36%)
tlr9	NP_001124066.1	leucine-rich repeat	39..57	CDD:275380
		LRR_8	56..129	CDD:290566
		leucine-rich repeat	58..81	CDD:275380
		LRR_RI	<73..312	CDD:238064
		leucine-rich repeat	82..118	CDD:275380
		leucine-rich repeat	119..138	CDD:275380
		leucine-rich repeat	139..192	CDD:275380
		LRR_8	191..246	CDD:290566
		leucine-rich repeat	193..213	CDD:275380
		leucine-rich repeat	214..237	CDD:275380
		leucine-rich repeat	238..279	CDD:275380
		LRR_RI	274..>422	CDD:238064	7/35 (20%)
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..323	CDD:275380
		leucine-rich repeat	360..386	CDD:275380
		leucine-rich repeat	387..408	CDD:275380	5/21 (24%)
		LRR_8	490..545	CDD:290566	22/54 (41%)
		leucine-rich repeat	490..509	CDD:275380	9/18 (50%)
		leucine-rich repeat	510..534	CDD:275380	7/23 (30%)
		leucine-rich repeat	535..559	CDD:275380	11/71 (15%)
		leucine-rich repeat	560..589	CDD:275380	10/28 (36%)
		leucine-rich repeat	590..612	CDD:275380	2/22 (9%)
		LRR_8	612..679	CDD:290566	27/79 (34%)
		leucine-rich repeat	613..643	CDD:275380	10/30 (33%)
		leucine-rich repeat	644..668	CDD:275380	11/35 (31%)
		leucine-rich repeat	669..692	CDD:275380	7/49 (14%)
		leucine-rich repeat	693..714	CDD:275380	9/25 (36%)
		TIR_2	894..1040	CDD:304906
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900