Protein Alignment rdo and tlr3

DIOPT Version :10

• Sequence 1: NP_001286024.1
• Gene: rdo / 35077
• FlyBaseID: FBgn0243486
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_001013287.2
• Gene: tlr3 / 403126
• ZFINID: ZDB-GENE-040219-7
• Length: 903
• Species: Danio rerio
• Alignment Length: 438
• Identity: 111/438 - (25%)
• Similarity: 194/438 - (44%)
• Gaps: 53/438 - (12%)

  Fly    83 KLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLELDLSKNKVLRMAS 147
            |:.:|.::::.:..|...:|..|..|..|.|..|.|.::|.::|.|..||.:|:|.|..:...||
Zfish   276 KITVLDLSENRISKIVDGAFQWLPQLEFLSLEHNTIRHLTNDSFSGLGNLRQLNLRKALIKSHAS 340

  Fly   148 ------STFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGN--PLQDLQPDVF---RDV 201
                  .:|:||..|..|.:|:.:..||.::.|..|..||.||||.:  .::.:....|   ::.
Zfish   341 LPVIDDFSFQHLVQLEYLCMANTAFRELTEQIFSGLRNLKTLDLSWSITGIKTVTNKTFAGLQES 405

  Fly   202 PELKVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEFKFLDK----DEFRDVKRLTKVLLDGNQL 262
            |.|:.|......:.|:.|..::.|..||.|.:.||   |:::    :||:.:..:.::.:..||.
Zfish   406 PLLQTLNLTGMGINKLEPGAFSSLGNLSNLLMSRN---FINQQLQGNEFKGLSNIKEIDMSINQQ 467

  Fly   263 SV-VVDQLFRMQKSLNHLDLSYNRLAKVPND----SFLQLTNLTFLDLSYNKLVRLEPQSIRSLS 322
            |: :.:..|....:|..|.|  .|..|...|    .|..|.|||.||||.|.:..:....:..|.
Zfish   468 SISLTNASFVHVSTLRTLKL--GRALKGTLDMEPSPFRPLVNLTILDLSNNNIANINADLLEGLY 530

  Fly   323 NLLTLNISGNVLMDLREMRETFEPLIYYFFLTCSKLFFQLIPQLTHLAIADMG--TMPVGLLHPF 385
            ||..:.:..|.|..|.:|.....|:          ||.:....|::|.:...|  .:|......|
Zfish   531 NLKVVKMQHNNLARLWKMANPGGPV----------LFLKDATNLSYLNLDYNGIDEIPPNAFRGF 585

  Fly   386 KQLRYLNISGNSLNNTALEVIDPCRELEFLDLSRNQLHGISEDTV-LRIQGIRNVRLDNNPLICD 449
            .:|..|::.||.|:.....|.|....|::|.|.:|.:..:...|. :.:..::.:.:|:||..|
Zfish   586 SELHELSLRGNLLDQLHASVFDDLNSLKYLHLQKNLITSVQRATFGVPLSKLKELNMDHNPFDC- 649

  Fly   450 ECHMGKLINVVRQLQWKWDT------YP---ICFLPKSLRGAEINNLD 488
            .|.     :::...:|...|      :|   ||..|.:.....:.|.|
Zfish   650 TCE-----SILWFSEWLNSTNTSVPGFPQSYICNTPNAYFNHSVMNFD 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	LRR	69..>446	CDD:443914	100/385 (26%)
		leucine-rich repeat	84..107	CDD:275380	4/22 (18%)
		leucine-rich repeat	108..131	CDD:275380	8/22 (36%)
		leucine-rich repeat	132..155	CDD:275380	9/28 (32%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..203	CDD:275380	7/27 (26%)
		leucine-rich repeat	204..251	CDD:275380	13/50 (26%)
		leucine-rich repeat	252..275	CDD:275380	4/23 (17%)
		leucine-rich repeat	276..299	CDD:275380	8/26 (31%)
		leucine-rich repeat	300..323	CDD:275380	8/22 (36%)
		leucine-rich repeat	388..411	CDD:275380	7/22 (32%)
tlr3	NP_001013287.2	LRR	<54..436	CDD:443914	45/159 (28%)
		leucine-rich repeat	57..77	CDD:275380
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..125	CDD:275380
		leucine-rich repeat	126..148	CDD:275380
		leucine-rich repeat	149..172	CDD:275380
		leucine-rich repeat	173..276	CDD:275380	111/438 (25%)
		leucine-rich repeat	278..300	CDD:275380	4/21 (19%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..354	CDD:275380	9/28 (32%)
		leucine-rich repeat	355..378	CDD:275380	7/22 (32%)
		LRR	368..>666	CDD:443914	78/318 (25%)
		leucine-rich repeat	379..404	CDD:275380	7/24 (29%)
		leucine-rich repeat	408..431	CDD:275380	5/22 (23%)
		leucine-rich repeat	432..456	CDD:275380	8/26 (31%)
		leucine-rich repeat	457..507	CDD:275380	12/51 (24%)
		leucine-rich repeat	482..498	CDD:275380	6/17 (35%)
		leucine-rich repeat	508..531	CDD:275380	8/22 (36%)
		leucine-rich repeat	532..563	CDD:275380	8/40 (20%)
		leucine-rich repeat	564..587	CDD:275380	5/22 (23%)
		leucine-rich repeat	588..611	CDD:275380	7/22 (32%)
		leucine-rich repeat	612..630	CDD:275380	4/17 (24%)
		Tlr3_TMD	698..730	CDD:465595
		TIR	756..898	CDD:214587