DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and tlr21

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001186264.1	Gene:	tlr21 / 402884	ZFINID:	ZDB-GENE-040220-4	Length:	989	Species:	Danio rerio

Alignment Length:	561	Identity:	131/561 - (23%)
Similarity:	225/561 - (40%)	Gaps:	93/561 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LFSLCIMPAMFSNTKRKCPTECQCSMDDLDRYQAICTKGGLNSLLSPNELDVDVKVIIIRGPRNS 71
            |.|||::....|:...:.|                      ..||..|.:.. :|       .|:
Zfish   293 LSSLCVLMRNHSHKHLQIP----------------------KMLLQSNSIGA-LK-------NNT 327

  Fly    72 ITIGPALRQFMKLEILRITDSNLPAIGAESF-WGLKYLRILDLSKNNITNITE-NNFRGQDNLLE 134
            ....|::.:.|.|     :.:.|.:.|...| .....|:.|.:..|::|.:|. |.....::|..
Zfish   328 FRYCPSITREMDL-----SRNELKSAGCLQFLHNQTQLKSLKMEHNHLTKLTSCNKAEIHNSLTN 387

  Fly   135 LDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPDVFR 199
            |....|::|:::...|.:...|..|.|..|.|..:..:....|..||.|.|..|.|.|:..|.|.
Zfish   388 LSYRYNRILQISGYAFSNTPKLEILELNINIIAYMDHKALSGLKDLKTLRLDNNLLSDIYNDSFE 452

  Fly   200 DVPELKVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQLSV 264
            |:..||.|..||.::..|....:..|..|..||||.|:...|....|..:..||.:.||.|.|.:
Zfish   453 DLTNLKTLNLRNNEIAVIFNYTFQNLSKLDILDLGGNKISQLKPHAFDGLYSLTNLYLDRNHLKM 517

  Fly   265 VVDQLF-RMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFL-DLSYN----KLVRLEPQS-IRSLS 322
            :...|| ::..:|..|||..|.:......:.....|::.| ||..|    ..:.|.|:: .|.|:
Zfish   518 IDVVLFGKLSGTLQVLDLQGNMIMYFTEHTHSPFKNMSRLYDLKLNGQQPNGINLLPRAFFRGLT 582

  Fly   323 NLLTLNISGNVLMDLREMRETFEPLIYYFFLTCSKLFFQLIPQLTHLAIADMGTMPVGLLHPFKQ 387
            :|.:|.::.|.::...:  |||:.|....:||...            :.|.:..:..|:....::
Zfish   583 SLKSLYLTNNHIIGFGD--ETFDDLKNLDYLTLDN------------SCAGVAQLQSGIFKSLQK 633

  Fly   388 LRYLNISGNSLNNTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPLICDECH 452
            ||.|::....:.:.:.:|......|:.|.|:||.:..:....:..:..:..:.:.:.||.|. ||
Zfish   634 LRTLSLENMGIKSFSKDVFGNLTGLKTLHLNRNPMMSLDISLLDNLTNLIYIDMRSCPLSCG-CH 697

  Fly   453 MGKLIN---VVRQLQWKWDTYPICF---LPKSLRGAEINNLDINGLHTCLTFITDEEQNAASTSY 511
            ...|.|   :.::||     :|..|   .|.. .|:..:|.|     |.:.::..|....:|||
Zfish   698 NSDLQNWTIMNKRLQ-----FPHLFNITCPDH-PGSYFHNFD-----TKVCYLDIELYFFSSTS- 750

  Fly   512 NFLEHGGLNTLAILGGIIFVLIAVIILSLVACFSKNRARYY 552
                     ||.|       |:.:|.|..|..:.|.:..||
Zfish   751 ---------TLTI-------LLTLIPLLYVKLYWKFKYGYY 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	4/23 (17%)
		leucine-rich repeat	108..131	CDD:275380	6/23 (26%)
		LRR_8	131..190	CDD:290566	16/58 (28%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		LRR_RI	151..422	CDD:238064	73/277 (26%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		LRR_8	178..262	CDD:290566	30/83 (36%)
		leucine-rich repeat	180..203	CDD:275380	10/22 (45%)
		leucine-rich repeat	204..251	CDD:275380	15/46 (33%)
		leucine-rich repeat	252..275	CDD:275380	8/23 (35%)
		LRR_8	274..334	CDD:290566	17/65 (26%)
		leucine-rich repeat	276..299	CDD:275380	5/22 (23%)
		LRR_4	298..342	CDD:289563	12/49 (24%)
		leucine-rich repeat	300..323	CDD:275380	8/28 (29%)
		leucine-rich repeat	388..411	CDD:275380	4/22 (18%)
tlr21	NP_001186264.1	leucine-rich repeat	65..85	CDD:275380
		LRR_8	84..144	CDD:290566
		leucine-rich repeat	86..109	CDD:275380
		LRR_RI	107..350	CDD:238064	15/91 (16%)
		leucine-rich repeat	110..133	CDD:275380
		leucine-rich repeat	134..157	CDD:275380
		LRR_8	156..217	CDD:290566
		leucine-rich repeat	158..183	CDD:275380
		leucine-rich repeat	184..206	CDD:275380
		leucine-rich repeat	207..229	CDD:275380
		leucine-rich repeat	230..253	CDD:275380
		LRR_RI	<336..540	CDD:238064	60/208 (29%)
		leucine-rich repeat	360..383	CDD:275380	6/22 (27%)
		leucine-rich repeat	385..408	CDD:275380	5/22 (23%)
		LRR_8	407..467	CDD:290566	21/59 (36%)
		leucine-rich repeat	409..432	CDD:275380	6/22 (27%)
		leucine-rich repeat	433..456	CDD:275380	10/22 (45%)
		LRR_8	455..515	CDD:290566	20/59 (34%)
		leucine-rich repeat	457..480	CDD:275380	7/22 (32%)
		leucine-rich repeat	481..504	CDD:275380	8/22 (36%)
		leucine-rich repeat	505..529	CDD:275380	8/23 (35%)
		leucine-rich repeat	530..556	CDD:275380	6/25 (24%)
		LRR_8	555..615	CDD:290566	17/61 (28%)
		leucine-rich repeat	557..583	CDD:275380	8/25 (32%)
		LRR_8	582..668	CDD:290566	20/99 (20%)
		leucine-rich repeat	584..607	CDD:275380	7/24 (29%)
		leucine-rich repeat	608..633	CDD:275380	4/36 (11%)
		leucine-rich repeat	634..657	CDD:275380	4/22 (18%)
		leucine-rich repeat	658..679	CDD:275380	5/20 (25%)
		leucine-rich repeat	682..694	CDD:275378	2/11 (18%)
		TIR	797..942	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900