DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and CG4950

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	628	Identity:	153/628 - (24%)
Similarity:	245/628 - (39%)	Gaps:	158/628 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PTECQ--CSMDDLDRYQAICTKGGLNSLLSPNELDVDVKVIIIRG--PRNSITIGPALRQFMKLE 85
            |..|.  .||..:|..:|.||..|.....|.|        ::|:.  |.|.:       :|||
  Fly    29 PLRCDEYDSMGYMDVNEAFCTVTGFTVTHSQN--------VVIKNIPPGNMV-------KFMK-- 76

  Fly    86 ILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLELDLSKNKVLRMASSTF 150
               ..:|.|..:....|....||:.||:|..||..:|.|.|....||..|:|:.|.:..:.:|.|
  Fly    77 ---FYESTLLYMPFHLFETFPYLKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSVF 138

  Fly   151 RHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPDVFRDVPELKVLKCRNCQLK 215
            .....|.||:|:.|.|..|....|..|..:..:.|:||.|::|..|:|:|...|:.:......|.
  Fly   139 IGANVLMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLT 203

  Fly   216 KINPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQL--------SVV------- 265
            .|.|:::..:..:.|::|..|...|:..|.|.|...|..::|..|:|        ::|
  Fly   204 SIQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKNFQLTEKNIVHQLHLDN 268

  Fly   266 --------------------VDQLFRMQK-SLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNK 309
                                :.:||..|. .:..||||.|:|:.:.|  ...:|::.:||:|.|.
  Fly   269 NYLTNLTINATRFVRASHNQISELFLHQSLHIETLDLSANKLSSISN--ITNITHMLYLDVSDNP 331

  Fly   310 LVRLEPQSIRSLSNLLTLNISGNVLMDLR----EMRETFEPL-IYYFFLTCSKLFFQLIPQLTHL 369
            :..|...:...|..|..||:.|..:.:|:    ..::..|.| :.:..||...| ...:|.||:|
  Fly   332 IGPLNISTFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNNLTILNL-DMFVPYLTNL 395

  Fly   370 AIADMGTMPVGLLHPFKQLRYLNISGNSL-----NNTALEVIDPCRELEFLDLSRNQ-----LH- 423
            .                  ::| |.||.|     |.|..|...   :|:.|.:|||:     ||
  Fly   396 K------------------KFL-IDGNGLTELQGNRTFSEAFP---QLQKLGVSRNRFNCSYLHH 438

  Fly   424 -----GISEDTVLRIQGIRNVRLDNNPLICDECHMGKLINVVRQLQWKWDTYPICFLPKSLRGAE 483
                 .:.|..||.|:...|  ||..|.|.|       ::.:.|.|                  |
  Fly   439 LLIPPSLPESVVLNIEPDTN--LDETPHIRD-------VSCISQSQ------------------E 476

  Fly   484 INNLDING----LHTCLTFITDEEQNAASTSYNFLEHGGLNTLA-------ILGGIIFVLIAVII 537
            :.|.....    |.:.:..::.:.....|.|.|...|     ||       ::||:  ||:.|:.
  Fly   477 VVNASFTAEESKLESQIQMLSKQLDIVGSHSKNLELH-----LAFMQIFAYVMGGL--VLVGVVS 534

  Fly   538 LSLVACFSKNRARYYTREDHLNGSESKCLEKNLEATTITTLGN 580
            |..:......|:..|.|...:..|.: .:|.||      |||:
  Fly   535 LITLRYLKNQRSGRYDRSSIVFRSNA-TMEANL------TLGS 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	3/22 (14%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_8	131..190	CDD:290566	19/58 (33%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		LRR_RI	151..422	CDD:238064	77/321 (24%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		LRR_8	178..262	CDD:290566	22/83 (27%)
		leucine-rich repeat	180..203	CDD:275380	8/22 (36%)
		leucine-rich repeat	204..251	CDD:275380	11/46 (24%)
		leucine-rich repeat	252..275	CDD:275380	8/58 (14%)
		LRR_8	274..334	CDD:290566	18/60 (30%)
		leucine-rich repeat	276..299	CDD:275380	7/22 (32%)
		LRR_4	298..342	CDD:289563	12/47 (26%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	388..411	CDD:275380	8/27 (30%)
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	9/22 (41%)
		LRR_8	118..178	CDD:290566	19/59 (32%)
		leucine-rich repeat	120..143	CDD:275380	6/22 (27%)
		leucine-rich repeat	144..167	CDD:275380	9/22 (41%)
		leucine-rich repeat	168..191	CDD:275380	8/22 (36%)
		LRR_8	192..250	CDD:290566	14/57 (25%)
		leucine-rich repeat	192..215	CDD:275380	4/22 (18%)
		LRR_RI	<207..432	CDD:238064	57/249 (23%)
		leucine-rich repeat	216..239	CDD:275380	7/22 (32%)
		leucine-rich repeat	240..299	CDD:275380	8/58 (14%)
		LRR_8	299..356	CDD:290566	18/58 (31%)
		leucine-rich repeat	300..321	CDD:275380	7/22 (32%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	344..405	CDD:290566	18/80 (23%)
		leucine-rich repeat	346..365	CDD:275380	5/18 (28%)
		leucine-rich repeat	370..394	CDD:275380	7/24 (29%)
		leucine-rich repeat	395..420	CDD:275380	9/46 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442133
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840