DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and trn

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster

Alignment Length:	842	Identity:	192/842 - (22%)
Similarity:	310/842 - (36%)	Gaps:	210/842 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 W-LLFSLCIMPAM-FSNTKRKCPTECQCSMDDLDRYQAICTKGGLNSLLSPNELDVDVKVIIIRG 67
            | :|.|:.:.||. .:|    ||..|||  || :.....|.:|.|:.|  |..|:..::.::|:.
  Fly    13 WCILASIGVEPAAGLAN----CPPGCQC--DD-NTLVVQCGEGQLDVL--PIALNPSIQRLVIKS 68

  Fly    68 PRNSITIGPALRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNL 132
            .:                 ::..||::      .|:.  .|..||||.|::..|.:..|..|..|
  Fly    69 NK-----------------IKTIDSSI------QFYA--ELTFLDLSSNHLMTIPQRTFAYQKKL 108

  Fly   133 LELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPDV 197
            .|:.|:.||:.::::.||..|:.:..|||..|.|.||.|..|..|.:::.|:|..|.:..|.|..
  Fly   109 QEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKA 173

  Fly   198 FRDVPELKVLKCRNCQLKKI-NPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQ 261
            |..:.:|::|...:..|..: :|.::..:|.|:||.||.|..:.:..|.|:|:|.||::.|.|..
  Fly   174 FDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGAS 238

  Fly   262 LSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLT 326
            |..:....|...:.|..||||.|||.::|:....:|..|..|.|..|....:...:...|..|..
  Fly   239 LRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKR 303

  Fly   327 LNISGNVLMDLREMRETFEP--LIYYFFLTCSKLFFQLIPQLTHLAIADMGTMPVGLLHPFKQLR 389
            |.::|.:.:. |.|...|..  .:.|..|:.:|:..:               :..|.|....||:
  Fly   304 LEVNGALRLK-RVMTGAFSDNGNLEYLNLSSNKMLLE---------------VQEGALSGLSQLK 352

  Fly   390 YLNISGNSLNNTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPLICDECHMG 454
            ::.:..|:|.:.| |.:.|.::|:.||||                        .|||.|| |.:.
  Fly   353 HVVLKANALTSLA-EGLFPWKDLQTLDLS------------------------ENPLSCD-CRVM 391

  Fly   455 KLINVVRQLQWKWDTYP--ICFLPKSLRGAEINNLDINGLHTCLTFITDEEQNAASTSYNFLEHG 517
            .|.|::.......|...  :|..|:.|||..:.:|                 |.|...   ..|.
  Fly   392 WLHNLLVAKNASQDDVSELLCEFPERLRGESLRHL-----------------NPAMMG---CTHA 436

  Fly   518 GLNTLAILGGIIF---VLIAVIILSLVACFSK----------------NRARYYTR----EDHLN 559
            .....|::|.::.   ..|..:.|.|..|..|                .:.|.|.:    ||:::
  Fly   437 DPRKQALIGALLVGSAATITALALVLYRCRHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMS 501

  Fly   560 GSESKCLEKNLEATTITTLGNGSSPTTTTTLTLATSPAAPNG---PKTNGQGLSLSPA------- 614
            ..:.......:.:|...|......|..|....:...|....|   |:...|.|.:..|
  Fly   502 RHQHHPCSLGIHSTFPNTYTAPHHPGATHHYGMCPMPVNDLGAIDPQQKFQQLVVPTATMISEKK 566

  Fly   615 ---NGSTPVHGISDDKGKEINFTFPVDDRVCTIDELMPSPPPPPQQHPHPNMGSLMYSVSHSPNS 676
               |.:....|..||..     :|.:..:..|:...:....|....:..|...|...:|..|..|
  Fly   567 LNNNKALVSQGAIDDSA-----SFVLHMKSATMGRDVHQQNPQLNHYTKPQFLSATATVGDSCYS 626

  Fly   677 ATTLAAVAAAATVIPPGAP-----------------------------------SHSSMP----- 701
            ...:..|..|    |.|.|                                   :|.|||
  Fly   627 YADVPMVHGA----PLGGPNQPQLRLTQEHFKQRELYDQEMGSEILDHNYIYSNTHYSMPLEQLG 687

  Fly   702 ---TPTPTPAEAVVVVLPPPPLPPQQ------HHHQMDGSLASLREVQ-----QQLVHLSST 749
               ||||.|.        ||.||.:.      .........||.::.|     :|..|.|||
  Fly   688 RSKTPTPPPM--------PPALPLRNGLCATTGRRSFQQKSASQKQQQNNNTLRQFTHXSST 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	3/22 (14%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_8	131..190	CDD:290566	21/58 (36%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		LRR_RI	151..422	CDD:238064	76/273 (28%)
		leucine-rich repeat	156..179	CDD:275380	10/22 (45%)
		LRR_8	178..262	CDD:290566	25/84 (30%)
		leucine-rich repeat	180..203	CDD:275380	6/22 (27%)
		leucine-rich repeat	204..251	CDD:275380	14/47 (30%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		LRR_8	274..334	CDD:290566	18/59 (31%)
		leucine-rich repeat	276..299	CDD:275380	10/22 (45%)
		LRR_4	298..342	CDD:289563	10/43 (23%)
		leucine-rich repeat	300..323	CDD:275380	5/22 (23%)
		leucine-rich repeat	388..411	CDD:275380	6/22 (27%)
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	3/40 (8%)
		LRR_8	83..142	CDD:290566	21/58 (36%)
		leucine-rich repeat	84..107	CDD:275380	9/22 (41%)
		leucine-rich repeat	108..131	CDD:275380	8/22 (36%)
		LRR_RI	129..421	CDD:238064	89/333 (27%)
		LRR_8	132..190	CDD:290566	18/57 (32%)
		leucine-rich repeat	132..155	CDD:275380	10/22 (45%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		leucine-rich repeat	180..204	CDD:275380	4/23 (17%)
		LRR_8	203..263	CDD:290566	23/59 (39%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_8	252..308	CDD:290566	17/55 (31%)
		leucine-rich repeat	253..276	CDD:275380	10/22 (45%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		leucine-rich repeat	301..322	CDD:275380	6/21 (29%)
		LRR_8	325..384	CDD:290566	18/98 (18%)
		leucine-rich repeat	326..350	CDD:275380	5/38 (13%)
		leucine-rich repeat	351..373	CDD:275380	6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453573
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840