DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdo and CG6749

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	127/498 - (25%)
Similarity:	195/498 - (39%)	Gaps:	109/498 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LFKWLL---------FSLCIMPAMFSNTKRKCPTECQC----SMDDL-----DRYQAICTK---- 44
            |..|||         ..|| .|..:.|        .||    |:.||     :.:..:..:
  Fly    11 LLLWLLCMGFPILHGADLC-QPIGWRN--------FQCSEVASLQDLVDLGAENWHTLAIRNVQT 66

  Fly    45 -----GGLNSLLSPNELDVDVK-VIIIRGPRNSITIGPALRQFMKLEILRITDSNLPAIGAESFW 103
                 .|.|:....|.||:|:. ...|....|..:|.|.|||      |.::...|..|....|.
  Fly    67 ELEVGSGENADHLANLLDLDLTGAAPINVHTNGFSILPNLRQ------LNLSGCGLVDIRGNHFA 125

  Fly   104 GLKYLRILDLSKN-----------NITNITENNFRGQDNLLELDLSKNKVL--------RMASST 149
            ....|:.:|.|.|           |:..:...|| ..:.|.:.||....:|        |:.::|
  Fly   126 PESALQRIDFSHNQMELLDRDFFGNLRKLIYANF-SHNALKQCDLPHMPLLNRLELGHNRLVNAT 189

  Fly   150 FRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPDVFRDVPELKVLKCRNCQL 214
            |.....|:.|.|.||.:::|....|..|..|..|.||||.|..:..:.|:.:.:|:.|......|
  Fly   190 FGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNAL 254

  Fly   215 KKINPQMY----NLLPLLSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVVDQLFRMQKS 275
            ..:.|.::    |.:..|.:|||..|..:.|..::||.:.||..:.:..|.::.:....|....|
  Fly   255 DALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGS 319

  Fly   276 LNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSI--RSLSNLLTLNISGNVLMDLR 338
            |..|.|.||.:.::...:|..|.||..||||||.|..||.|..  .:|..:..||::||.:..|
  Fly   320 LRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHL- 383

  Fly   339 EMRETFEPLIYYFFLTCSKLFFQLIPQLTHLAIADMGTMPVGLLHPFKQLRYLNISGNSLNNTAL 403
                  .||.:      |.|                         ||  |.||.:..|.|.:..:
  Fly   384 ------HPLAF------SSL-------------------------PF--LEYLKLGHNELKSLDV 409

  Fly   404 EVIDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPL 446
            .:..|.|.|:.|.|..|.|..|:.|.:..:..::.:.:|||.|
  Fly   410 RMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRL 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	4/22 (18%)
		leucine-rich repeat	108..131	CDD:275380	7/33 (21%)
		LRR_8	131..190	CDD:290566	21/66 (32%)
		leucine-rich repeat	132..155	CDD:275380	7/30 (23%)
		LRR_RI	151..422	CDD:238064	76/276 (28%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		LRR_8	178..262	CDD:290566	24/87 (28%)
		leucine-rich repeat	180..203	CDD:275380	8/22 (36%)
		leucine-rich repeat	204..251	CDD:275380	13/50 (26%)
		leucine-rich repeat	252..275	CDD:275380	3/22 (14%)
		LRR_8	274..334	CDD:290566	25/61 (41%)
		leucine-rich repeat	276..299	CDD:275380	7/22 (32%)
		LRR_4	298..342	CDD:289563	18/45 (40%)
		leucine-rich repeat	300..323	CDD:275380	12/24 (50%)
		leucine-rich repeat	388..411	CDD:275380	6/22 (27%)
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	41/159 (26%)
		LRR_8	104..164	CDD:290566	15/66 (23%)
		leucine-rich repeat	106..129	CDD:275380	7/28 (25%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	9/41 (22%)
		LRR_RI	194..455	CDD:238064	83/299 (28%)
		LRR_8	194..254	CDD:290566	18/59 (31%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	4/22 (18%)
		LRR_8	271..330	CDD:290566	18/58 (31%)
		leucine-rich repeat	272..295	CDD:275380	8/22 (36%)
		leucine-rich repeat	296..319	CDD:275380	3/22 (14%)
		LRR_8	319..380	CDD:290566	25/60 (42%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	12/24 (50%)
		LRR_8	368..428	CDD:290566	22/99 (22%)
		leucine-rich repeat	370..393	CDD:275380	9/60 (15%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453579
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840