DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and Toll-7

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster

Alignment Length:	839	Identity:	180/839 - (21%)
Similarity:	290/839 - (34%)	Gaps:	262/839 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NTKRKCPTECQCSMDDL-------DRYQAICTKG------GLNSLLSPNELDV-DVKVIIIRGPR 69
            |..|:.|:...|.:.:|       :|.:.....|      |..|..:.:||.| |.....:|
  Fly   199 NNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELR--- 260

  Fly    70 NSITIGPALRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLE 134
             ||:....:.:..:|:.|.:..:||..:..|:..||..|||::||.|::..:.|..|.|...|.|
  Fly   261 -SISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELRE 324

  Fly   135 LDLSKNKVLRMASSTFRHLTDLRRLNLADNSIV--ELVQRNFFMLSRLKYLDLSGNPLQDLQPDV 197
            :.|.:|::..:....|..|..|..::|:.|.:.  .:....|..|.||..|:|:.|.|..:....
  Fly   325 IHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRT 389

  Fly   198 FRDVPELKVLKCRNCQLKKINPQMYNLLPL--LSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGN 260
            |:::..|::|..||..:..|....:  |||  |..|:|..|....||...|..:..|:|:.|:.|
  Fly   390 FKELYFLQILNLRNNSIGHIEDNAF--LPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNN 452

  Fly   261 QLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLL 325
            .:|||...:|:....|..||||.|:|.:||. :...|..|..|||..|::...:.||.::|.
  Fly   453 LISVVEPAVFKNCSDLKELDLSSNQLNEVPR-ALQDLAMLRTLDLGENQIRTFDNQSFKNLH--- 513

  Fly   326 TLNISGNVLMDLREMRETFEPLIYYFFLTCSKLFFQLIPQLTHLAIAD--MGTMPVGLLHPFKQL 388
                                                   |||.|.:.|  :|.:.||:.....:|
  Fly   514 ---------------------------------------QLTGLRLIDNQIGNITVGMFQDLPRL 539

  Fly   389 RYLNISGNSLNNTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPLICDECHM 453
            ..||::.|.:.:......|...|||.:.|.||.|..|: .....:..:..:.|..|.|:
  Fly   540 SVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADIN-GVFATLVSLLWLNLSENHLV------ 597

  Fly   454 GKLINVVRQLQWKWDTYPICFLPKSLRGAEINNLDINGLHTCLTFITDEEQNAASTSYNFLEHGG 518
                         |..|  .|:|.:|:.     |||:|                    |::|..|
  Fly   598 -------------WFDY--AFIPSNLKW-----LDIHG--------------------NYIEALG 622

  Fly   519 LNTLAILGGIIFVLIAVIILSLVACFSKNRARYYTREDHLNGSESKCLEKNLEAT--TITTLGNG 581
                                           .||..::.:.       .|.|:|:  .||.:|..
  Fly   623 -------------------------------NYYKLQEEIR-------VKTLDASHNRITEIGPM 649

  Fly   582 SSPTTTTTLTLATS---PAAPNG-----------------PKTNGQGLSLSPANGSTPVHGISDD 626
            |.|.|...|.:..:   ...||.                 .|...|.|.::|.....|:
  Fly   650 SIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPL------ 708

  Fly   627 KGKEINF---TFPVDDRVCTIDELMPSPPPPPQQHP--------------------HPNMG---- 664
              .|...   .|..|   ||:|.|........:|||                    .|..|
  Fly   709 --PEFYLGGNPFECD---CTMDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQ 768

  Fly   665 -------SLMYSVSH------------SPNSATTLAAVAAAATVIPPGAPSHSSMPTPTPTPAEA 710
                   |..:::.|            .|::.|.......:..|:..|....:.:  |...|.::
  Fly   769 DFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTEL--PRRVPMDS 831

  Fly   711 VVVVLPPPPLPPQQHH----------------------HQMDGSLASLREVQQQLVHLS 747
            .||.|.....|..::|                      ::...|||||     ||:||:
  Fly   832 SVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASL-----QLLHLA 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	7/22 (32%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_8	131..190	CDD:290566	16/60 (27%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		LRR_RI	151..422	CDD:238064	73/276 (26%)
		leucine-rich repeat	156..179	CDD:275380	5/24 (21%)
		LRR_8	178..262	CDD:290566	26/85 (31%)
		leucine-rich repeat	180..203	CDD:275380	6/22 (27%)
		leucine-rich repeat	204..251	CDD:275380	15/48 (31%)
		leucine-rich repeat	252..275	CDD:275380	8/22 (36%)
		LRR_8	274..334	CDD:290566	18/59 (31%)
		leucine-rich repeat	276..299	CDD:275380	10/22 (45%)
		LRR_4	298..342	CDD:289563	8/43 (19%)
		leucine-rich repeat	300..323	CDD:275380	8/22 (36%)
		leucine-rich repeat	388..411	CDD:275380	5/22 (23%)
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	1/1 (100%)
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	13/59 (22%)
		leucine-rich repeat	191..214	CDD:275380	4/14 (29%)
		leucine-rich repeat	215..248	CDD:275380	5/32 (16%)
		LRR_RI	247..501	CDD:238064	79/260 (30%)
		LRR_8	247..308	CDD:290566	20/64 (31%)
		leucine-rich repeat	249..273	CDD:275380	6/27 (22%)
		leucine-rich repeat	274..297	CDD:275380	7/22 (32%)
		LRR_8	297..356	CDD:290566	18/58 (31%)
		leucine-rich repeat	298..321	CDD:275380	9/22 (41%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	16/60 (27%)
		leucine-rich repeat	346..371	CDD:275380	5/24 (21%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	8/24 (33%)
		LRR_8	419..478	CDD:290566	21/58 (36%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	8/22 (36%)
		LRR_RI	466..622	CDD:238064	53/245 (22%)
		leucine-rich repeat	468..488	CDD:275380	9/20 (45%)
		LRR_8	491..549	CDD:290566	20/99 (20%)
		leucine-rich repeat	491..514	CDD:275380	8/64 (13%)
		leucine-rich repeat	515..536	CDD:275380	7/20 (35%)
		leucine-rich repeat	539..562	CDD:275380	5/22 (23%)
		leucine-rich repeat	563..585	CDD:275380	7/22 (32%)
		leucine-rich repeat	586..626	CDD:275380	16/116 (14%)
		leucine-rich repeat	627..653	CDD:275380	7/32 (22%)
		LRRCT	716..772	CDD:214507	11/58 (19%)
		LRRNT	796..830	CDD:214470	6/35 (17%)
		leucine-rich repeat	812..829	CDD:275380	3/18 (17%)
		leucine-rich repeat	833..854	CDD:275380	5/20 (25%)
		LRR_8	853..913	CDD:290566	9/38 (24%)
		leucine-rich repeat	855..878	CDD:275380	2/22 (9%)
		LRR_4	878..918	CDD:289563	6/13 (46%)
		leucine-rich repeat	879..902	CDD:275380	5/12 (42%)
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453765
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740