DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and Tlr3

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_942086.2	Gene:	Tlr3 / 364594	RGDID:	735171	Length:	905	Species:	Rattus norvegicus

Alignment Length:	646	Identity:	158/646 - (24%)
Similarity:	246/646 - (38%)	Gaps:	189/646 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LFSLCIMPAMFSNTKRKCPTECQCSMDDLDRYQ-AICTKGGLNSLLSPNELDVDVKVI------- 63
            |.||.|:....:|         ||::    ||. |.|:...|..:  |::|..::.|:
  Rat    15 LLSLWILVVSSTN---------QCTV----RYNVADCSHLKLTHI--PDDLPSNITVLNLTHNQL 64

  Fly    64 ---------------IIRGPRNSIT-IGPALRQFMK-LEILRITDSNLPAIGAESFWGLKYLRIL 111
                           ::....|||: :.|.|.|.:. |::|.:..:.|..|..::|.....|..|
  Rat    65 RGLPPANFTRYSQLALLDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFAFCTNLTEL 129

  Fly   112 DLSKNNITNITENNFRGQDNLLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVEL--VQRNF 174
            .|..|:|..|..|.|:.|.:|::||||:|.:......|...|.:|:.|.||.|.|..|  .:.:|
  Rat   130 HLMSNSIRKIKSNPFKNQKSLIKLDLSRNGLSSTKLGTGVQLENLQELLLAKNKIFALRSEELDF 194

  Fly   175 FMLSRLKYLDLSGNPLQDLQPDVFRDVPELKVLKCRNCQL-----KKINPQMYNLLPLLSELDLG 234
            ...|.|:.||||.|||::..|..|..:.:|.||...|.||     :|:..::.|  ..:..|.|.
  Rat   195 LGNSSLQKLDLSSNPLKEFSPGCFHAIGKLFVLLLNNAQLNLNLTEKLCWELSN--TSIQNLSLA 257

  Fly   235 RNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTN 299
            .|:........|..:|                      |.:|..||||||.|..|.||:|..|.:
  Rat   258 NNQLLATSNSTFSGLK----------------------QTNLTSLDLSYNSLRYVGNDAFSWLPH 300

  Fly   300 LTFLDLSYNKLVRLEPQSIRSLSNLL---------------------------------TLNISG 331
            |.:|.|.||.:..|.|.|.|.||||.                                 .||:..
  Rat   301 LKYLSLEYNNIQSLTPHSFRGLSNLRYLSLKRAFTKQSVALASHPNIDDFSFQWLKCLEHLNMDD 365

  Fly   332 NVLMDLREMRETFEPLIYYFFLTCSKLFFQL-------IPQLTH--------------------- 368
            |.:..::.  .||..|:...:|:.||.|..|       ...|||
  Rat   366 NTIPGIKS--NTFTGLVSLKYLSLSKTFTGLQTLTNETFVSLTHSPLLTLNLTKNHISKIASGTF 428

  Fly   369 -----LAIADMGTMPV----------GLLHPFK----QLRYLNISGNS-----------LNNTAL 403
                 |.|.|:|...:          ||.:.|:    ..:||.::..|           |...||
  Rat   429 SWLGQLRILDLGLNEIEQELTGQEWRGLGNIFEIYLSYNKYLQLTSKSFTLVPSLQRLMLRRVAL 493

  Fly   404 EVID-------PCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRL-----DNNPLICDECHMGKL 456
            :.:|       |...|..||||.|.:..::||.   ::|:.|:.:     :|...:....:.|..
  Rat   494 KSVDISPSPFRPLYNLTILDLSNNNIANLNEDL---LEGLENLEILDFQHNNLARLWKHANPGGP 555

  Fly   457 INVVRQLQW---------KWDTYPICFLPKSLRGAEINNLDINGLHTCLTFITDEEQNAAS 508
            :|.::.|..         ..|..|:... |:|...:..||.:|.|:|.|..|.|::.:..|
  Rat   556 VNFLKGLSHLHILNLESNGLDEIPVKVF-KNLFELKSINLGLNNLNTLLPSIFDDQTSLRS 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	5/22 (23%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_8	131..190	CDD:290566	23/60 (38%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		LRR_RI	151..422	CDD:238064	95/375 (25%)
		leucine-rich repeat	156..179	CDD:275380	8/24 (33%)
		LRR_8	178..262	CDD:290566	24/88 (27%)
		leucine-rich repeat	180..203	CDD:275380	10/22 (45%)
		leucine-rich repeat	204..251	CDD:275380	12/51 (24%)
		leucine-rich repeat	252..275	CDD:275380	1/22 (5%)
		LRR_8	274..334	CDD:290566	29/92 (32%)
		leucine-rich repeat	276..299	CDD:275380	13/22 (59%)
		LRR_4	298..342	CDD:289563	16/76 (21%)
		leucine-rich repeat	300..323	CDD:275380	10/22 (45%)
		leucine-rich repeat	388..411	CDD:275380	8/40 (20%)
Tlr3	NP_942086.2	leucine-rich repeat	37..53	CDD:275380	4/17 (24%)
		leucine-rich repeat	54..77	CDD:275380	1/22 (5%)
		PLN00113	66..>646	CDD:215061	143/580 (25%)
		leucine-rich repeat	78..101	CDD:275380	6/22 (27%)
		leucine-rich repeat	102..125	CDD:275380	5/22 (23%)
		leucine-rich repeat	126..149	CDD:275380	9/22 (41%)
		leucine-rich repeat	150..199	CDD:275380	16/48 (33%)
		leucine-rich repeat	200..250	CDD:275380	18/51 (35%)
		leucine-rich repeat	251..276	CDD:275380	6/46 (13%)
		leucine-rich repeat	277..300	CDD:275380	13/22 (59%)
		leucine-rich repeat	301..322	CDD:275380	9/20 (45%)
		leucine-rich repeat	325..381	CDD:275380	7/57 (12%)
		leucine-rich repeat	382..407	CDD:275380	6/24 (25%)
		leucine-rich repeat	410..433	CDD:275380	0/22 (0%)
		leucine-rich repeat	434..458	CDD:275380	6/23 (26%)
		leucine-rich repeat	459..482	CDD:275380	4/22 (18%)
		leucine-rich repeat	483..508	CDD:275380	5/24 (21%)
		leucine-rich repeat	509..532	CDD:275380	9/25 (36%)
		leucine-rich repeat	533..564	CDD:275380	4/30 (13%)
		leucine-rich repeat	565..586	CDD:275380	3/21 (14%)
		leucine-rich repeat	589..612	CDD:275380	8/22 (36%)
		leucine-rich repeat	613..631	CDD:275380	1/3 (33%)
		LRRCT	646..698	CDD:214507
		Tlr3_TMD	699..731	CDD:407816
		TIR	756..901	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900