DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and kek2

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster

Alignment Length:	872	Identity:	175/872 - (20%)
Similarity:	285/872 - (32%)	Gaps:	355/872 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 W--LLFSLCIMPAMFSNTKRKCPTE-CQCSMDDLDRYQAICTKGGLNSL------LS--PNELDV 58
            |  ||..|.|..|        ||.| |.|..           |||..::      ||  |..:|.
  Fly     7 WIPLLALLAITAA--------CPPEVCVCKW-----------KGGKQTVECGGQQLSNLPEGMDP 52

  Fly    59 DVKVIIIRGPRNSITIGPALRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITE 123
            ..:|:...|  |::.:..:.| |:::::|.                   |:.:.||:|.:..|.|
  Fly    53 GTQVLNFSG--NALQVLQSER-FLRMDLLN-------------------LQKIYLSRNQLIRIHE 95

  Fly   124 NNFRGQDNLLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGN 188
            ..|||..||:|||||:|.:..:.|.||:..:.|.||:                        ||||
  Fly    96 KAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLS------------------------LSGN 136

  Fly   189 PLQDLQPDVFRDVPELKVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKRLT 253
            |:::|:...||.:..|..|:..|||:::|                        :.:.|..:..|.
  Fly   137 PIRELKTSAFRHLSFLTTLELSNCQVERI------------------------ENEAFVGMDNLE 177

  Fly   254 KVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSI 318
            .:.||||::. .:.....:.|||:.:.|..||.     :...:|.::.|..::||..:..||:.:
  Fly   178 WLRLDGNRIG-FIQGTHILPKSLHGISLHSNRW-----NCDCRLLDIHFWLVNYNTPLAEEPKCM 236

  Fly   319 RSLSNLLTLNISGNVLMDLREMRETFEPLIYYFFLTCSKLFFQLIPQLTHLAIADMGTMPVGLLH 383
            .      ...:.|.|:..|:  ||.         |.|       :|:::
  Fly   237 E------PARLKGQVIKSLQ--REQ---------LAC-------LPEVS---------------- 261

  Fly   384 PFKQLRYLNIS-GNSLNNTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPLI 447
              .|..|..:| |.:::.|.|                  :..|.|..||   .:.|.::.:|..:
  Fly   262 --PQSSYTEVSEGRNMSITCL------------------VRAIPEPKVL---WLFNGQVMSNDSL 303

  Fly   448 CDECHMGKLINVVRQLQWKWDTYPICFLPKSLRGAEINNLDI---------NGLHTCLTFITDEE 503
            .|..||...|:         :|.       .:.|||....:|         ||..:|:      .
  Fly   304 MDNLHMYYYID---------ETI-------GVSGAEEKRSEIFIYNVGAEDNGTFSCV------G 346

  Fly   504 QNAASTSY-NFLEHGGLNTLAIL--------------------------GGIIFVLIAVIILSLV 541
            ||.|.|:: |:       ||.::                          ||||||::...|  :|
  Fly   347 QNIAGTTFSNY-------TLRVIIKEPPVVNEVSFPRDYMNYIVASSAGGGIIFVVLLCTI--VV 402

  Fly   542 ACF-----SKNRARY---------------YTRE----------------DHLNGSESKCLEKNL 570
            .|.     :|.|.:.               .|::                |.:||:....|...|
  Fly   403 KCKKTSEPAKQRKKCDQVTSIAGGTDSSTGSTQDTGMGMMKCASILNDGGDSMNGNPGLLLGDTL 467

  Fly   571 EATTITT--------LGNGSSPTTTTTLT--------------LATSPAAPNGPKTNGQGLSLSP 613
            ..|....        |||..........|              :.|.|.:|....:||.||:.:.
  Fly   468 TPTKAANGAAGGGIILGNQMKQNLLLYATPNSAQQQLQLNVNLMGTGPGSPPLLLSNGHGLAAAY 532

  Fly   614 ANGSTPVHGISDDKGKEINFTFPVDDRVCTIDEL--------------------MPSPPPPPQQH 658
            .:....:....:.....:|....|..::.|...|                    :.:.|.|.|.|
  Fly   533 CSPPASLRNYQEKNPDLVNDAESVKHKLKTAVSLDGAGEYETQSDCGQYEGCYQLAAAPHPHQGH 597

  Fly   659 PHPNMGSLMYSVSHSPNSATTLAAVAAAATVIPPGAPSHSSMPTPTPTPAEAVVVVLPPPPLPPQ 723
            .||:.|..:            :...|.|.|.:|.|                   :.|.|.|....
  Fly   598 QHPHPGHPL------------MGRFAQAMTTLPRG-------------------MQLKPAPHQVD 631

  Fly   724 QHHHQM-----DGSLA----SLREVQQ 741
            .|.:.:     |||.|    |...|||
  Fly   632 VHLNPVCFLGQDGSFAYDYSSAHMVQQ 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	1/22 (5%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_8	131..190	CDD:290566	18/58 (31%)
		leucine-rich repeat	132..155	CDD:275380	10/22 (45%)
		LRR_RI	151..422	CDD:238064	49/271 (18%)
		leucine-rich repeat	156..179	CDD:275380	3/22 (14%)
		LRR_8	178..262	CDD:290566	20/83 (24%)
		leucine-rich repeat	180..203	CDD:275380	8/22 (36%)
		leucine-rich repeat	204..251	CDD:275380	7/46 (15%)
		leucine-rich repeat	252..275	CDD:275380	5/22 (23%)
		LRR_8	274..334	CDD:290566	13/59 (22%)
		leucine-rich repeat	276..299	CDD:275380	5/22 (23%)
		LRR_4	298..342	CDD:289563	8/43 (19%)
		leucine-rich repeat	300..323	CDD:275380	5/22 (23%)
		leucine-rich repeat	388..411	CDD:275380	5/23 (22%)
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	3/17 (18%)
		leucine-rich repeat	54..79	CDD:275380	5/27 (19%)
		LRR_8	79..138	CDD:290566	27/101 (27%)
		LRR_RI	<80..187	CDD:238064	43/154 (28%)
		leucine-rich repeat	80..103	CDD:275380	9/22 (41%)
		leucine-rich repeat	104..127	CDD:275380	10/22 (45%)
		LRR_8	126..186	CDD:290566	23/107 (21%)
		leucine-rich repeat	128..151	CDD:275380	11/46 (24%)
		leucine-rich repeat	152..175	CDD:275380	7/46 (15%)
		leucine-rich repeat	176..198	CDD:275380	5/22 (23%)
		TPKR_C2	207..256	CDD:301599	14/70 (20%)
		I-set	258..361	CDD:254352	32/170 (19%)
		Ig_2	263..361	CDD:290606	31/147 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100