DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and Toll-4

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	120/566 - (21%)
Similarity:	202/566 - (35%)	Gaps:	201/566 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 CPTECQCSMD------DLDRYQAICT--------KGGLNSLLSPNELDVDVKVIIIRGPRNSITI 74
            ||.:|.||.:      ::|.:|...|        |.|.::|:..:.|..::....:.|..|..::
  Fly   372 CPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSL 436

  Fly    75 GPALRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITE---------NNFRGQD 130
            ..:..|...|.:.::.:|               |..||:..|.||.::.         |.|....
  Fly   437 DVSYNQLTSLSVSQLPES---------------LHYLDIRHNKITTLSPQVVEYLYSVNVFNQYG 486

  Fly   131 N----------LLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFM--LSRLKYL 183
            |          |.|....|.|:||:.:|.|:.:.:...|: :..|.||    |||:  :.:| ||
  Fly   487 NKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELS-SKGSFVE----NFFVQNIDQL-YL 545

  Fly   184 DLSGNPLQDL--QPDVFRDVPELKVL--------------------------------------- 207
            :.:.:.:.|.  ..|.:.::..::.|
  Fly   546 EANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFL 610

  Fly   208 -KCRNCQLKKINPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVVDQLFR 271
             .|||..| .|.|::.|.:|..:.|.|.|||           :::||      |..|:||    .
  Fly   611 INCRNLSL-DIYPRLPNSIPYKTTLYLDRNE-----------IRKLT------NTESLVV----A 653

  Fly   272 MQKSLNHLDLSYNRLAKVPNDSFLQL--TNLTFLDLSYNKLVRLEPQSIRSL---SNLLTLNISG 331
            ...|::.|.:|.|.|.::|    |.|  .|:|:||:..|.|..|:...|..|   .|:..:.:||
  Fly   654 GHASIHKLHMSQNLLRELP----LHLLPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSG 714

  Fly   332 N----------VLMDLREMRETFEPLIY------------------------------YFFLTCS 356
            |          .|..||.    .||:.|                              .:.:.||
  Fly   715 NPWECNCKAKAFLSFLRR----HEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCS 775

  Fly   357 KLFFQLIPQL-------THLAIA--DMGTMPVGLLHPFKQLRYLNISGNSLNNTALEVIDPCRE- 411
            ......||||       |.|...  .:...|..||..:..:....::.|.|::     ||...:
  Fly   776 GKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSD-----IDQLPDK 835

  Fly   412 LEFLDLSRNQLHGISEDTVLRIQGIRNVRLDN---------NPLIC 448
            ||:||:|.|....:.:    |::|....|:::         ||..|
  Fly   836 LEYLDISNNNFSALDD----RVRGFLQKRMNSSQLQLSLFGNPWTC 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	2/22 (9%)
		leucine-rich repeat	108..131	CDD:275380	8/31 (26%)
		LRR_8	131..190	CDD:290566	19/70 (27%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		LRR_RI	151..422	CDD:238064	80/369 (22%)
		leucine-rich repeat	156..179	CDD:275380	7/24 (29%)
		LRR_8	178..262	CDD:290566	22/125 (18%)
		leucine-rich repeat	180..203	CDD:275380	5/24 (21%)
		leucine-rich repeat	204..251	CDD:275380	14/86 (16%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		LRR_8	274..334	CDD:290566	21/74 (28%)
		leucine-rich repeat	276..299	CDD:275380	7/24 (29%)
		LRR_4	298..342	CDD:289563	16/56 (29%)
		leucine-rich repeat	300..323	CDD:275380	8/25 (32%)
		leucine-rich repeat	388..411	CDD:275380	4/22 (18%)
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	5/13 (38%)
		leucine-rich repeat	388..408	CDD:275380	4/19 (21%)
		LRR_8	412..465	CDD:290566	11/67 (16%)
		leucine-rich repeat	412..432	CDD:275378	3/19 (16%)
		LRR_4	432..470	CDD:289563	10/52 (19%)
		leucine-rich repeat	433..454	CDD:275378	2/20 (10%)
		leucine-rich repeat	455..478	CDD:275378	6/22 (27%)
		leucine-rich repeat	479..490	CDD:275378	3/10 (30%)
		leucine-rich repeat	632..657	CDD:275378	11/45 (24%)
		leucine-rich repeat	658..679	CDD:275378	7/24 (29%)
		leucine-rich repeat	680..706	CDD:275378	8/25 (32%)
		leucine-rich repeat	707..719	CDD:275378	3/11 (27%)
		leucine-rich repeat	771..791	CDD:275380	6/19 (32%)
		leucine-rich repeat	793..815	CDD:275378	5/21 (24%)
		leucine-rich repeat	816..835	CDD:275378	4/23 (17%)
		leucine-rich repeat	836..859	CDD:275378	8/26 (31%)
		TIR	974..1110	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453759
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830