DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and Tlr7

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	XP_017457568.1	Gene:	Tlr7 / 317468	RGDID:	1563357	Length:	1068	Species:	Rattus norvegicus

Alignment Length:	641	Identity:	150/641 - (23%)
Similarity:	245/641 - (38%)	Gaps:	189/641 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 ALRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNIT-NITENNF-RGQDNLLELDLSK 139
            |.....:|::||:..::|..:.||.|..:..|:.||||:|.:. .|.|..| ....||::||||.
  Rat   303 AFDSLTELKVLRLHSNSLQHVPAEWFKNMSNLQELDLSQNYLAREIEEAKFLNSLPNLVQLDLSF 367

  Fly   140 NKVLRM--ASSTFRH----LTDLRRL--------NLADNSI------------------VELVQR 172
            |..|::  ||.|..|    ||.|:.|        .|.|:|:                  :::...
  Rat   368 NYELQVYHASITLPHSLSSLTKLKNLYIKGYVFKELKDSSLSVLHNLSNLEVLDLGTNFIKIADL 432

  Fly   173 NFF-MLSRLKYLDLSGNPLQ--------DLQPDVFRDV----PE-LKVLK-------CRNCQLKK 216
            |.| ....||::|||.|.:.        .|.|:....|    |: |:.|.       .|:|:.|.
  Rat   433 NIFQQFENLKFIDLSVNKISPSEESREVGLCPNAQTSVDWHGPQVLEALHYFRYDEYARSCRFKN 497

  Fly   217 INPQMYNLLPLLSE-------LDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVVD-QLFRMQ 273
            ..|..:  |||.::       |||.||...|:...:|:.:..|..:.|.||.:...:: ...:..
  Rat   498 KEPPTF--LPLNADCHTYGKTLDLSRNNIFFIKPSDFKHLSFLKCLNLSGNAIGQTLNGSELQPL 560

  Fly   274 KSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYN-----------------KLVRLE------- 314
            :.|.:||.|.|||..:.:.:|.:|.||..||||.|                 ||..||
  Rat   561 RELRYLDFSNNRLDLLYSTAFEELQNLEILDLSSNSHYFQAEGITHMLNFTKKLRHLEKLMMNDN 625

  Fly   315 ---PQSIRSL--SNLLTLNISGNVLMDL-----REMRETFEPLIYYFFLTCSK---------LFF 360
               ..:.|::  .:|..|...||.|..|     ....:.|:.|:....|..|:         :|.
  Rat   626 DISTSASRTMESESLRVLEFRGNHLDVLWRDGDNRYLDFFKNLLNLEELDISRNSLNSVPPGVFE 690

  Fly   361 QLIPQLTHLAIADMG--------------------------TMPVGLLHPFKQLRYLNISGNSLN 399
            .:.|.||.|::|..|                          |:|..|.:..|.|..|.::.|.:.
  Rat   691 GMPPNLTTLSLAKNGLRSFSWGRLQLLKHLKNLDLSHNQLTTVPARLANCSKSLTKLILNHNQIR 755

  Fly   400 NTALEVIDPCRELEFLDLSRNQLHGISE----DTVLRIQGIRNVRLDNNPLICDECHMGKLINVV 460
            ......::...:|.:||:|.|::..|.:    :.||  ..:..:.|.:|..:|: |.....:
  Rat   756 QLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVL--NNLNMLLLHHNRFLCN-CDAVWFV--- 814

  Fly   461 RQLQWKW-----DTYP------ICFLPKSLRGAEINNLDINGLHTCLTFITDEEQNAASTSYNFL 514
                | |     .|.|      .|..|.:.:|..:.:||   |:||...:|:....:.|.|
  Rat   815 ----W-WVNHTDVTIPYLATDVTCAGPGAHKGQSVISLD---LYTCELDLTNLILFSVSIS---- 867

  Fly   515 EHGGLNTLAILGGIIFVLIAVIILSL-------VACFSKNRARYYTREDHLNGSES 563
                        .::|::|.:....|       :..|.|.:.:.|   .||...||
  Rat   868 ------------SVLFLMIVMTTSHLFFWDMWYIYYFWKAKIKGY---QHLQSMES 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	7/22 (32%)
		leucine-rich repeat	108..131	CDD:275380	9/24 (38%)
		LRR_8	131..190	CDD:290566	27/91 (30%)
		leucine-rich repeat	132..155	CDD:275380	12/28 (43%)
		LRR_RI	151..422	CDD:238064	90/398 (23%)
		leucine-rich repeat	156..179	CDD:275380	7/49 (14%)
		LRR_8	178..262	CDD:290566	30/110 (27%)
		leucine-rich repeat	180..203	CDD:275380	9/34 (26%)
		leucine-rich repeat	204..251	CDD:275380	16/60 (27%)
		leucine-rich repeat	252..275	CDD:275380	4/23 (17%)
		LRR_8	274..334	CDD:290566	25/88 (28%)
		leucine-rich repeat	276..299	CDD:275380	9/22 (41%)
		LRR_4	298..342	CDD:289563	18/77 (23%)
		leucine-rich repeat	300..323	CDD:275380	11/51 (22%)
		leucine-rich repeat	388..411	CDD:275380	3/22 (14%)
Tlr7	XP_017457568.1	leucine-rich repeat	66..87	CDD:275380
		LRR_8	93..157	CDD:290566
		leucine-rich repeat	109..146	CDD:275380
		leucine-rich repeat	147..191	CDD:275380
		leucine-rich repeat	192..223	CDD:275380
		LRR_8	222..277	CDD:290566
		LRR_RI	223..472	CDD:238064	47/168 (28%)
		leucine-rich repeat	224..244	CDD:275380
		leucine-rich repeat	245..268	CDD:275380
		leucine-rich repeat	269..309	CDD:275380	1/5 (20%)
		LRR_8	308..368	CDD:290566	22/59 (37%)
		leucine-rich repeat	310..333	CDD:275380	7/22 (32%)
		leucine-rich repeat	334..359	CDD:275380	9/24 (38%)
		leucine-rich repeat	370..389	CDD:275380	6/18 (33%)
		leucine-rich repeat	390..416	CDD:275380	5/25 (20%)
		leucine-rich repeat	417..440	CDD:275380	2/22 (9%)
		LRR_8	515..573	CDD:290566	16/57 (28%)
		leucine-rich repeat	515..537	CDD:275380	7/21 (33%)
		LRR_RI	532..778	CDD:238064	55/245 (22%)
		leucine-rich repeat	538..562	CDD:275380	4/23 (17%)
		LRR_8	561..627	CDD:290566	20/65 (31%)
		leucine-rich repeat	563..586	CDD:275380	9/22 (41%)
		leucine-rich repeat	587..616	CDD:275380	8/28 (29%)
		leucine-rich repeat	617..639	CDD:275380	3/21 (14%)
		LRR_8	639..706	CDD:290566	16/66 (24%)
		leucine-rich repeat	640..670	CDD:275380	8/29 (28%)
		leucine-rich repeat	671..695	CDD:275380	3/23 (13%)
		LRR_8	694..754	CDD:290566	13/59 (22%)
		leucine-rich repeat	696..719	CDD:275380	5/22 (23%)
		leucine-rich repeat	720..743	CDD:275380	3/22 (14%)
		leucine-rich repeat	768..786	CDD:275380	6/17 (35%)
		TIR	909..1054	CDD:214587	150/641 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900