DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdo and Cd180

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001099875.1	Gene:	Cd180 / 294706	RGDID:	1308170	Length:	662	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	121/521 - (23%)
Similarity:	213/521 - (40%)	Gaps:	114/521 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 GGLNSLLSPNELDVDVKVIIIRGPRNSITIGPALRQFMKLEILRITDSNLPAIGAESFWGLKYLR 109
            ||..|||           :|.:|.:||......|..|..::    .|.:   |.:..|.||..:.
  Rat   230 GGTQSLL-----------VIFKGLQNSTIQSLWLGTFEDID----DDED---ISSSMFEGLCEMS 276

  Fly   110 I--LDLSKNNITNITENNFRGQDNLLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQR 172
            :  ::|.|::..|||.|.|.....|.||||           |..|||:|      .:.||.
  Rat   277 VERINLQKHHFFNITSNTFYCFSGLQELDL-----------TATHLTEL------PSGIVG---- 320

  Fly   173 NFFMLSRLKYLDLSGNPLQDLQPDVFRDVPELKVLKCR-NCQLKKINPQMYNLLPLLSELDLGRN 236
                ||:||.|.||.|..::|......:.|.|..|..: |.:..::.......|..|.||||..:
  Rat   321 ----LSKLKKLVLSANKFENLCQISASNFPSLTHLYIKGNTKRLELGSGCLETLEHLRELDLSHD 381

  Fly   237 EFKFLD--KDEFRDVKRLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRL-AKVPNDSFLQLT 298
            :.:..|  ..:.|::..|..:.|..|:...:..:.|:....|..|||::.|| .|.....|..|.
  Rat   382 DIETSDCCNLQLRNLSHLQSLNLSYNEPLGLRTEAFKECPQLELLDLAFTRLHVKDAQSPFQNLH 446

  Fly   299 NLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVLMDLREMRETFEPLIYYFFLTCSKLFFQLI 363
            .|..|:||:..|.......:..|..|..||:.||...: ..:::| .||.....|....|.|..:
  Rat   447 LLKVLNLSHCLLGSSNQHLLDGLPALRHLNLQGNRFPN-GNIQKT-NPLQALGSLEILILSFCDL 509

  Fly   364 PQLTHLAIADMGTMPVGLLHPFKQLRYLNISGNSLNNTALEVIDPCRELEFLDLSRNQLHGISED 428
            ..:.|.|..::           |.:.::::|.|.|.::::|.:...:.: :|:|:.|::..|...
  Rat   510 SSIDHQAFINL-----------KIMNHVDLSHNRLTSSSIEALSHLKGI-YLNLASNRISIIPPS 562

  Fly   429 TVLRIQGIRNVRLDNNPLICDEC-----------HMGKLINVVRQLQWKWDTYPICFLPKSLRGA 482
            .:..:...|.:.|..|||.| .|           :|.||.::.       ||:  |..|..|||.
  Rat   563 LLPVLSQQRTINLRQNPLDC-TCSNIYFLEWYKENMQKLEDIE-------DTF--CANPPLLRGV 617

  Fly   483 EINNLDINGLHTCLTFITDEEQNAASTSYNFLEHGGLNTLAILGGIIFVLIAVIILSLVACFSKN 547
            :::::    :.:|                         ::|.: ||.|:::.:::.:::..|:..
  Rat   618 KVSDV----MLSC-------------------------SMAAV-GIFFLIVFLLLFAVLLIFAVK 652

  Fly   548 R 548
            |
  Rat   653 R 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	5/22 (23%)
		leucine-rich repeat	108..131	CDD:275380	7/24 (29%)
		LRR_8	131..190	CDD:290566	20/58 (34%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		LRR_RI	151..422	CDD:238064	67/274 (24%)
		leucine-rich repeat	156..179	CDD:275380	4/22 (18%)
		LRR_8	178..262	CDD:290566	23/86 (27%)
		leucine-rich repeat	180..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..251	CDD:275380	11/49 (22%)
		leucine-rich repeat	252..275	CDD:275380	4/22 (18%)
		LRR_8	274..334	CDD:290566	20/60 (33%)
		leucine-rich repeat	276..299	CDD:275380	9/23 (39%)
		LRR_4	298..342	CDD:289563	11/43 (26%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	388..411	CDD:275380	4/22 (18%)
Cd180	NP_001099875.1	leucine-rich repeat	55..78	CDD:275380
		leucine-rich repeat	79..102	CDD:275380
		leucine-rich repeat	103..126	CDD:275380
		leucine-rich repeat	127..150	CDD:275380
		leucine-rich repeat	151..174	CDD:275380
		leucine-rich repeat	175..195	CDD:275380
		leucine-rich repeat	196..223	CDD:275380
		leucine-rich repeat	224..244	CDD:275380	7/24 (29%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_RI	301..480	CDD:238064	55/203 (27%)
		leucine-rich repeat	301..323	CDD:275380	13/46 (28%)
		LRR_8	322..383	CDD:290566	18/60 (30%)
		leucine-rich repeat	324..347	CDD:275380	7/22 (32%)
		leucine-rich repeat	348..372	CDD:275380	4/23 (17%)
		LRR_8	372..433	CDD:290566	15/60 (25%)
		leucine-rich repeat	373..398	CDD:275380	7/24 (29%)
		leucine-rich repeat	399..422	CDD:275380	4/22 (18%)
		LRR_8	421..482	CDD:290566	20/60 (33%)
		leucine-rich repeat	423..447	CDD:275380	9/23 (39%)
		leucine-rich repeat	448..471	CDD:275380	6/22 (27%)
		leucine-rich repeat	472..498	CDD:275380	8/27 (30%)
		LRR_8	498..556	CDD:290566	13/69 (19%)
		leucine-rich repeat	499..522	CDD:275380	5/33 (15%)
		leucine-rich repeat	523..546	CDD:275380	4/22 (18%)
		TPKR_C2	578..627	CDD:301599	16/87 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900