DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and Tlr5

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001139300.1	Gene:	Tlr5 / 289337	RGDID:	631351	Length:	871	Species:	Rattus norvegicus

Alignment Length:	641	Identity:	158/641 - (24%)
Similarity:	231/641 - (36%)	Gaps:	210/641 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 PALRQFMKLEI----LRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLELD 136
            |.|.|.:.||:    .|:|      ||.|:|..|..||||||.::.|..:..:.|:|..:|.||.
  Rat    79 PLLEQLLLLELGTQYARLT------IGQEAFRNLPNLRILDLGQSQIEVLNPDAFQGLPHLFELR 137

  Fly   137 L----SKNKVLRMASSTFRHLTDLRRLNLADNSIVEL-VQRNFFMLSRLKYLDLSGNPL-----Q 191
            |    ..|.|||  .:.||:|..|.||:|:.|.|..| :..:|..||.|..::.|.|.:     .
  Rat   138 LFDCGLSNAVLR--DAYFRNLNSLARLDLSANEIHSLHLHSSFQELSSLSDINFSFNRIFTLCED 200

  Fly   192 DLQP------------------DVFRDVPELKVLKCRN----CQLKKI----------------- 217
            :|||                  .||.|..     .|||    .:|:.:
  Rat   201 ELQPLQGRTLSFFGLKSTSLFSRVFVDWE-----ACRNPLRGIRLETLDLSENGWTAAILGNFSH 260

  Fly   218 ---------------------------NPQMYNLLPL----LSELDLGRNEFKFLDKDEFRDVKR 251
                                       :|.......|    :.:|||.......|:...|..:|.
  Rat   261 TIQGSHISSLILTYHIMGSGFGFQNIKDPDQSTFASLARSSVLQLDLSHGYIFSLNPRLFETLKD 325

  Fly   252 LTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQ 316
            |.|:.|..|:::.:.|..|....||..|:||||.|.::.|.:|..|.::.:|||..|.:..::.:
  Rat   326 LKKLNLAFNKINKISDYAFHGLDSLQILNLSYNLLGELYNSNFYGLPSIAYLDLQRNHIGIIQDR 390

  Fly   317 SIRSLSNLLTLNISGNVLMD-----------LREMRETFEPLI-------------------YYF 351
            :.|.|..|.||::..|.|..           |...:.|..|.:                   .||
  Rat   391 TFRLLKKLQTLDLRDNALKTIGFIPSVQMVLLGSNKLTHLPHVRFTANFIELSENGLENLSDLYF 455

  Fly   352 FLTCSKLFFQLIPQ------------------LTHLAIAD------------------------- 373
            .|....|.|.::.|                  |..|.:|:
  Rat   456 LLRIPGLQFLILNQNRLSSCSNVDYAPSQNLSLEQLFLAENMLQLAWETGLCWDIFKGLSRLQIL 520

  Fly   374 ------MGTMPVGLLHPFKQLRYLNISGNSLNNTALEVIDPCRELEFLDLSRNQLHGISEDTVLR 432
                  :..:|.|:.:....||.|::|.|.|  |.|........||.||:|||||  .|.|..|
  Rat   521 YLNNNYLNFLPPGIFNGLVALRMLSLSANRL--TMLSPGSLPANLEILDISRNQL--FSPDPGL- 580

  Fly   433 IQGIRNVRLDNNPLICDECHMGKLINVVRQLQWKW-----DTYPICFLPKSLRGAEINNLDINGL 492
            ...:|.:.:.:|..||| |.:...|..:.|.....     |.|  |..|.||.|:.:.|:.
  Rat   581 FSSLRALDITHNEFICD-CELSTFIVWLNQTNVTLFGSPADVY--CMYPNSLLGSSLYNIS---- 638

  Fly   493 HTCLTFITDEEQNAASTSYNFLEHGGLNTLAILGGIIFVLIAVIILSLV----ACF 544
                |...|||:  |..|.||       :|.||..:...|..||.|.:.    .||
  Rat   639 ----TKDCDEEE--AVRSLNF-------SLFILCTVTLTLFLVITLIVTKFRGICF 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	9/26 (35%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_8	131..190	CDD:290566	24/63 (38%)
		leucine-rich repeat	132..155	CDD:275380	11/26 (42%)
		LRR_RI	151..422	CDD:238064	90/425 (21%)
		leucine-rich repeat	156..179	CDD:275380	9/23 (39%)
		LRR_8	178..262	CDD:290566	26/158 (16%)
		leucine-rich repeat	180..203	CDD:275380	9/45 (20%)
		leucine-rich repeat	204..251	CDD:275380	11/98 (11%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		LRR_8	274..334	CDD:290566	21/59 (36%)
		leucine-rich repeat	276..299	CDD:275380	10/22 (45%)
		LRR_4	298..342	CDD:289563	12/54 (22%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	388..411	CDD:275380	8/22 (36%)
Tlr5	NP_001139300.1	LRR_8	<96..143	CDD:404697	19/52 (37%)
		PLN00113	<108..>384	CDD:215061	72/282 (26%)
		leucine-rich repeat	109..132	CDD:275380	9/22 (41%)
		leucine-rich repeat	133..158	CDD:275380	11/26 (42%)
		leucine-rich repeat	159..183	CDD:275380	9/23 (39%)
		leucine-rich repeat	184..217	CDD:275380	6/32 (19%)
		leucine-rich repeat	240..301	CDD:275380	3/60 (5%)
		leucine-rich repeat	302..325	CDD:275380	5/22 (23%)
		LRR	314..>578	CDD:227223	63/267 (24%)
		LRR_8	326..384	CDD:404697	21/57 (37%)
		leucine-rich repeat	326..349	CDD:275380	6/22 (27%)
		leucine-rich repeat	350..373	CDD:275380	10/22 (45%)
		leucine-rich repeat	374..397	CDD:275380	6/22 (27%)
		leucine-rich repeat	398..432	CDD:275380	7/33 (21%)
		leucine-rich repeat	433..461	CDD:275380	3/27 (11%)
		leucine-rich repeat	462..487	CDD:275380	3/24 (13%)
		leucine-rich repeat	488..516	CDD:275380	3/27 (11%)
		leucine-rich repeat	517..540	CDD:275380	2/22 (9%)
		leucine-rich repeat	541..559	CDD:275380	8/19 (42%)
		leucine-rich repeat	563..586	CDD:275380	12/25 (48%)
		PCC	567..>645	CDD:188093	27/91 (30%)
		TIR	706..856	CDD:396246
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900