DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rdo and Tlr2

DIOPT Version :9

Sequence 1:NP_001286024.1 Gene:rdo / 35077 FlyBaseID:FBgn0243486 Length:757 Species:Drosophila melanogaster
Sequence 2:XP_006501523.1 Gene:Tlr2 / 24088 MGIID:1346060 Length:794 Species:Mus musculus


Alignment Length:617 Identity:135/617 - (21%)
Similarity:239/617 - (38%) Gaps:147/617 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 WLLFSLCIMPAMFSNTKRKCPTECQCSMDDLDRYQAICTKGGLNSLLSPNELDVDVKVIIIRGPR 69
            ||.:.|..:..:||   ::|..:...|.|    ...:|.                       |..
Mouse    16 WLFWILVAITVLFS---KRCSAQESLSCD----ASGVCD-----------------------GRS 50

  Fly    70 NSITIGPALRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLE 134
            .|.|..|               |.|.|.          ::.||||.|.||.|...:.|...||..
Mouse    51 RSFTSIP---------------SGLTAA----------MKSLDLSFNKITYIGHGDLRACANLQV 90

  Fly   135 LDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDL-QPDVF 198
            |.|..:::..:....|..|..|..|:|:||.:..|....|..||.||||:|.|||.|.| ...:|
Mouse    91 LMLKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLF 155

  Fly   199 RDVPELKVLKCRN----CQLKKINPQMYNLLPLLSELD---LGRNEFKFLDKDEFRDVKRLTKVL 256
            .::..|:.|:..|    .::::|:   :..|..|:||:   |....::.......||:..||..|
Mouse   156 PNLTNLQTLRIGNVETFSEIRRID---FAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLTLHL 217

  Fly   257 LDGN-QLSVVVDQLFRMQKSLNHLDLSYNRLAK-----VPNDSF------LQLTNLTFLDLSYNK 309
            .:.. .|.:..|.|    .|:.:|:|....||:     :|.|..      |........|.|:|:
Mouse   218 SESAFLLEIFADIL----SSVRYLELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNE 278

  Fly   310 LVRLEPQSIRSLSNL----LTLNISG-------NVLMDLRE-----MRETFEPLIYYFFLTCSKL 358
            |::| .:.|..||.:    .|||..|       :|:.:|.:     :|....|..|.|:...:  
Mouse   279 LLKL-LRYILELSEVEFDDCTLNGLGDFNPSESDVVSELGKVETVTIRRLHIPQFYLFYDLST-- 340

  Fly   359 FFQLIPQLTHLAI--ADMGTMPVGLLHPFKQLRYLNISGN-----SLNNTALEVIDPCRELEFLD 416
            .:.|:.::..:.:  :.:..:|.......|.|.:|::|.|     .|.|:|.:...|  .|:.|.
Mouse   341 VYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWP--SLQTLV 403

  Fly   417 LSRNQLHGISE--DTVLRIQGIRNVRLDNNPL--ICDECHMGKLINVVRQLQWKWDTYPICFLPK 477
            ||:|.|..:.:  :.:|.::.:.::.:..|..  :.|.|            ||          |:
Mouse   404 LSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPDSC------------QW----------PE 446

  Fly   478 SLRGAEINNLDINGLHTCL--TFITDEEQNAASTSYN---------FLEHGGLNTLAILGGIIFV 531
            .:|...:::..|..:.||:  |....:..|....|::         ::....|.||........:
Mouse   447 KMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDSFSLFLPRLQELYISRNKLKTLPDASLFPVL 511

  Fly   532 LIAVIILSLVACFSKNRARYYTREDHLNGSES 563
            |:..|..:.|:.|||::...:.:.:.|...::
Mouse   512 LVMKIRENAVSTFSKDQLGSFPKLETLEAGDN 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdoNP_001286024.1 leucine-rich repeat 84..107 CDD:275380 3/22 (14%)
leucine-rich repeat 108..131 CDD:275380 9/22 (41%)
LRR_8 131..190 CDD:290566 22/58 (38%)
leucine-rich repeat 132..155 CDD:275380 5/22 (23%)
LRR_RI 151..422 CDD:238064 80/313 (26%)
leucine-rich repeat 156..179 CDD:275380 8/22 (36%)
LRR_8 178..262 CDD:290566 26/92 (28%)
leucine-rich repeat 180..203 CDD:275380 11/23 (48%)
leucine-rich repeat 204..251 CDD:275380 11/53 (21%)
leucine-rich repeat 252..275 CDD:275380 6/23 (26%)
LRR_8 274..334 CDD:290566 20/81 (25%)
leucine-rich repeat 276..299 CDD:275380 7/33 (21%)
LRR_4 298..342 CDD:289563 14/59 (24%)
leucine-rich repeat 300..323 CDD:275380 7/22 (32%)
leucine-rich repeat 388..411 CDD:275380 8/27 (30%)
Tlr2XP_006501523.1 internalin_A <58..>259 CDD:380193 62/217 (29%)
leucine-rich repeat 65..87 CDD:275378 9/21 (43%)
LRR_8 87..145 CDD:338972 21/57 (37%)
leucine-rich repeat 88..111 CDD:275378 5/22 (23%)
leucine-rich repeat 112..135 CDD:275378 8/22 (36%)
leucine-rich repeat 136..160 CDD:275378 11/23 (48%)
leucine-rich repeat 186..212 CDD:275380 6/25 (24%)
leucine-rich repeat 213..233 CDD:275380 6/23 (26%)
PRK15370 <350..>568 CDD:185268 40/218 (18%)
leucine-rich repeat 372..398 CDD:275380 8/27 (30%)
leucine-rich repeat 399..424 CDD:275380 7/24 (29%)
leucine-rich repeat 448..468 CDD:275380 4/19 (21%)
leucine-rich repeat 469..488 CDD:275380 2/18 (11%)
leucine-rich repeat 489..510 CDD:275380 3/20 (15%)
leucine-rich repeat 511..534 CDD:275380 6/22 (27%)
TPKR_C2 543..596 CDD:387596 0/1 (0%)
TIR 650..794 CDD:214587
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.