Protein Alignment rdo and Tlr1

DIOPT Version :9

• Sequence 1: NP_001286024.1
• Gene: rdo / 35077
• FlyBaseID: FBgn0243486
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_001263374.1
• Gene: Tlr1 / 21897
• MGIID: 1341295
• Length: 795
• Species: Mus musculus
• Alignment Length: 678
• Identity: 141/678 - (20%)
• Similarity: 239/678 - (35%)
• Gaps: 237/678 - (34%)

  Fly    63 IIIRGPRNSITIGPALRQFMKLE--ILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENN 125
            :||:.|..::|..|   :.:.|:  .|.::.:|:..:.......|..||:|.:|.|.:..:..:.
Mouse    30 LIIKRPNANLTRVP---KDLPLQTTTLDLSQNNISELQTSDILSLSKLRVLIMSYNRLQYLNISV 91

  Fly   126 FRGQDNLLELDLSKN--KVLRMASSTFRHLT-DLRRLNLADNSIVEL-VQRNFFMLSRLKYLDLS 186
            |:....|..||||.|  ||:      ..|.| .|:.|:|:.|:...| :.:.|..:|:|::|.||
Mouse    92 FKFNTELEYLDLSHNELKVI------LCHPTVSLKHLDLSFNAFDALPICKEFGNMSQLQFLGLS 150

  Fly   187 GNPLQDL-------------------------QPDVFRDVP------------------------ 202
            |:.:|..                         .|:..|.|.
Mouse   151 GSRVQSSSVQLIAHLNISKVLLVLGDAYGEKEDPESLRHVSTETLHIVFPSKREFRFLLDVSVST 215

  Fly   203 ----ELKVLKC----RNCQ-----LKKI--NPQMYNLLPLLSELDLGRNEF-KFLDKDEFRDVK- 250
                ||..:||    :.|.     |.|:  |.::.||  .|:.::...|.| ..|.......||
Mouse   216 TIGLELSNIKCVLEDQGCSYFLRALSKLGKNLKLSNL--TLNNVETTWNSFINILQIVWHTPVKY 278

  Fly   251 -RLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRLA--KVPNDSF-------------LQLTN 299
             .::.|.|.| ||:      |||   .|:.|.|...|:  :|..|.|             :.:.|
Mouse   279 FSISNVKLQG-QLA------FRM---FNYSDTSLKALSIHQVVTDVFSFPQSYIYSIFANMNIQN 333

  Fly   300 LTF-------------------LDLSYNKLVRLEPQSIRSLSNLLTLNISGNVLMDLREMRETFE 345
            .|.                   :|.:.|.|..:..:..|:|..|.||::..|.|.:|..:
Mouse   334 FTMSGTHMVHMLCPSQVSPFLHVDFTDNLLTDMVFKDCRNLVRLKTLSLQKNQLKNLENI----- 393

  Fly   346 PLIYYFFLTCSKLFFQLIPQLTHLAIADM---------GTMPVGLLHPFKQLRYLNISGNSLNNT 401
                  .||.:|        :|.|...|:         |.:|....   :.|..||:|.|.|..:
Mouse   394 ------ILTSAK--------MTSLQKLDISQNSLRYSDGGIPCAWT---QSLLVLNLSSNMLTGS 441

  Fly   402 ALEVIDPCRELEFLDLSRNQLHGI----------------------------------------- 425
            ....:.|  :::.|||..|::..|
Mouse   442 VFRCLPP--KVKVLDLHNNRIMSIPKDVTHLQALQELNVASNSLTDLPGCGAFSSLSVLVIDHNS 504

  Fly   426 ----SEDTVLRIQGIRNVRLDNNPLICDECHMGKLIN----VVRQLQWKW-DTYPICFLPKSLRG 481
                |||.....|.||::...|||..| .|.:...:.    |.|::...| |:|. |..|:|.||
Mouse   505 VSHPSEDFFQSCQNIRSLTAGNNPFQC-TCELRDFVKNIGWVAREVVEGWPDSYR-CDYPESSRG 567

  Fly   482 AEINNLDINGLHTCLTFITDEEQNAASTSYNFLEHGGLNTLAILGGIIFVLIAVIILSLVAC--- 543
            ..:.:..::.| :|.|.:......|.           :..||:.|..:.:...:.....:.|
Mouse   568 TALRDFHMSPL-SCDTVLLTVTIGAT-----------MLVLAVTGAFLCLYFDLPWYVRMLCQWT 620

  Fly   544 FSKNRARYYTREDHLNGSESKCLEKNLE 571
            .:::|||:...|:         |::||:
Mouse   621 QTRHRARHIPLEE---------LQRNLQ 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	4/24 (17%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		LRR_8	131..190	CDD:290566	22/62 (35%)
		leucine-rich repeat	132..155	CDD:275380	10/25 (40%)
		LRR_RI	151..422	CDD:238064	81/382 (21%)
		leucine-rich repeat	156..179	CDD:275380	6/23 (26%)
		LRR_8	178..262	CDD:290566	29/150 (19%)
		leucine-rich repeat	180..203	CDD:275380	9/75 (12%)
		leucine-rich repeat	204..251	CDD:275380	15/60 (25%)
		leucine-rich repeat	252..275	CDD:275380	8/22 (36%)
		LRR_8	274..334	CDD:290566	18/93 (19%)
		leucine-rich repeat	276..299	CDD:275380	7/37 (19%)
		LRR_4	298..342	CDD:289563	13/62 (21%)
		leucine-rich repeat	300..323	CDD:275380	6/41 (15%)
		leucine-rich repeat	388..411	CDD:275380	7/22 (32%)
Tlr1	NP_001263374.1	PRK15370	<38..>133	CDD:185268	26/103 (25%)
		LRR	<48..317	CDD:227223	67/286 (23%)
		leucine-rich repeat	50..73	CDD:275378	3/22 (14%)
		LRR 1	54..77		4/22 (18%)
		leucine-rich repeat	74..97	CDD:275378	6/22 (27%)
		LRR 2	78..101		4/22 (18%)
		leucine-rich repeat	98..118	CDD:275378	10/25 (40%)
		LRR 3	102..125		10/28 (36%)
		leucine-rich repeat	119..143	CDD:275378	6/23 (26%)
		LRR 4	126..150		6/23 (26%)
		leucine-rich repeat	144..156	CDD:275378	5/11 (45%)
		LRR 5	151..175		2/23 (9%)
		LRR 6	176..199		3/22 (14%)
		LRR 7	200..223		2/22 (9%)
		LRR 8	224..250		6/25 (24%)
		LRR 9	251..278		7/28 (25%)
		LRR 10	279..308		12/38 (32%)
		LRR 11	309..337		5/27 (19%)
		Interaction with bacterial lipopeptide. /evidence=ECO:0000250	316..319		0/2 (0%)
		LRR 12	338..361		1/22 (5%)
		leucine-rich repeat	355..376	CDD:275380	5/20 (25%)
		LRR 13	362..388		7/25 (28%)
		PRK15370	<377..>487	CDD:185268	26/133 (20%)
		leucine-rich repeat	377..402	CDD:275380	9/43 (21%)
		LRR 14	389..414		7/43 (16%)
		leucine-rich repeat	403..427	CDD:275380	4/26 (15%)
		LRR 15	415..437		6/24 (25%)
		leucine-rich repeat	428..449	CDD:275380	7/22 (32%)
		LRR 16	438..457		5/20 (25%)
		leucine-rich repeat	450..472	CDD:275380	5/21 (24%)
		LRR 17	458..478		2/19 (11%)
		leucine-rich repeat	473..494	CDD:275380	0/20 (0%)
		LRR 18	479..500		0/20 (0%)
		leucine-rich repeat	495..518	CDD:275380	3/22 (14%)
		LRR 19	501..524		6/22 (27%)
		LRRCT	527..581	CDD:214507	15/56 (27%)
		TIR	639..782	CDD:214587	0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900