DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and dma-1

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_492253.1	Gene:	dma-1 / 187968	WormBaseID:	WBGene00011345	Length:	603	Species:	Caenorhabditis elegans

Alignment Length:	706	Identity:	168/706 - (23%)
Similarity:	283/706 - (40%)	Gaps:	143/706 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLFKWLLFSLCIMPAMFSNTKRKCPTECQCSMDDLDRYQAICTKGGLNSLLSP---NELDVDVKV 62
            :|..:|.|.:....|:.|:    ||..|:|..:| ..:...|.|..:|..:..   |:|.:.::.
Worm     5 ILLLFLSFLVLCSIALPSS----CPNLCECDQND-SSWSVYCRKAIINDTIYAEILNQLPLTLRS 64

  Fly    63 IIIRGPRNSITIGPA-----LRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNIT 122
            :.|:.|.|.|.....     :.:|.:|.:||:.:..:||:....  .|..|.:|||..|||.:.|
Worm    65 LHIQPPSNRIGSNKLRWNDNINRFAQLRVLRLINCQIPAMSRSI--RLPSLEVLDLHSNNIEHAT 127

  Fly   123 ENNFRGQDNLLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSG 187
            .:||.|...|..||||.|.:..:.:..|.:|..||.|:|::|:|.:|.......|:.|:.|.|..
Worm   128 MSNFGGMPKLRVLDLSSNHLNILPTGVFTYLRALRSLSLSNNTISDLSTNLLRGLNSLRVLRLDR 192

  Fly   188 NPLQDLQP-----DVFRDVPELKVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEFKFLDKDEFR 247
            ||:    |     ::|.||.:|..|...:|.|..|.....:.:|.|.:|.:|.|..|.:...|.|
Worm   193 NPI----PIEHINELFTDVSQLDELYLNHCNLSSIYSLALDRIPQLRQLGIGGNNLKMVPTKELR 253

  Fly   248 DVKRLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRLA---KVP-NDSFLQLTNLTFLDLSYN 308
            .:.:|:.:.|..|.:..:....| ...:::.||||:|.|.   ..| |:...:...|..||||:|
Worm   254 SLPQLSVLDLSHNSIQEITACAF-CNTNISKLDLSHNLLGISKDSPFNEDAFRTMPLRHLDLSFN 317

  Fly   309 KLVRLEPQSIR-SLSNLLTLNISGNVLMDLREMRETFEPLIYYFFLTCSKLFFQLIPQLTHLAIA 372
            .:...:.:.:. :...|.::.:|||.|.:..|.                  :...:..|.||.:|
Worm   318 HMNDFDSKWLGWAQEELTSIALSGNFLKNFEES------------------WTYTLKSLIHLELA 364

  Fly   373 --DMGTMPVGLLHPFKQLRYLNISGNSLN------NTALEVIDPCRELEFLDLSRNQLHGISEDT 429
              .:..:||.|...:..|..||||||.|.      ||.|.      .::..|::.|:.|..|...
Worm   365 YNHIKFIPVQLPSRYYHLISLNISGNELTYLPDNINTLLP------NVKTFDITANRFHTFSHTD 423

  Fly   430 VLRIQGIRNVRLDNNPLICDECHMGKLINVVRQLQWKWDTYPI----------CFLPKSLRGAEI 484
            :..:..:..|.:|.||..|.....|..:::       .|.|.:          |..|..:.|..:
Worm   424 LAFLNNVEQVYVDGNPWDCSCAIQGLQVHM-------RDRYAMRHILNYDNVRCATPSLVEGHSV 481

  Fly   485 NNLDINGLHTCLTFITDEEQNAASTSYNFLEHGGLNTLAILGGIIFVLIAVIILSLVACFSKNRA 549
              |.|..::.|....        ...|...:...:  |.:|.|::  |.|.::|.::.|.
Worm   482 --LAITDVNDCAVLF--------GARYGLTQTSEM--LILLAGVL--LFAALLLMILGCI----- 527

  Fly   550 RYYTREDHLNGSESKCLEKNLEATTITTLGNGSSPTTTTTLTLATSPAAPNGPKTNGQGLSLSPA 614
             |:.||....||    ......:.|..|:.|..|.:::|..|        :||        |||
Worm   528 -YFLRERQYKGS----YVTREHSRTPLTMANTHSCSSSTNDT--------HGP--------LSP- 570

  Fly   615 NGSTPVHGISDDKGKEINFTFPVDDRVCTIDELMPSPPPPPQQHPHPNMGSLMYSV 670
                                 |.|..:.:.:....:||..|...|.|  ||..:.:
Worm   571 ---------------------PFDPFLVSTETFKATPPLIPPAPPKP--GSSYFGI 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	6/22 (27%)
		leucine-rich repeat	108..131	CDD:275380	11/22 (50%)
		LRR_8	131..190	CDD:290566	20/58 (34%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		LRR_RI	151..422	CDD:238064	75/288 (26%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		LRR_8	178..262	CDD:290566	25/88 (28%)
		leucine-rich repeat	180..203	CDD:275380	9/27 (33%)
		leucine-rich repeat	204..251	CDD:275380	13/46 (28%)
		leucine-rich repeat	252..275	CDD:275380	4/22 (18%)
		LRR_8	274..334	CDD:290566	18/64 (28%)
		leucine-rich repeat	276..299	CDD:275380	8/26 (31%)
		LRR_4	298..342	CDD:289563	12/44 (27%)
		leucine-rich repeat	300..323	CDD:275380	6/23 (26%)
		leucine-rich repeat	388..411	CDD:275380	11/28 (39%)
dma-1	NP_492253.1	LRR_8	90..147	CDD:338972	23/58 (40%)
		leucine-rich repeat	91..112	CDD:275380	6/22 (27%)
		leucine-rich repeat	113..136	CDD:275380	11/22 (50%)
		LRR	136..430	CDD:227223	84/322 (26%)
		leucine-rich repeat	137..160	CDD:275380	8/22 (36%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		leucine-rich repeat	185..209	CDD:275380	9/27 (33%)
		leucine-rich repeat	210..233	CDD:275380	5/22 (23%)
		leucine-rich repeat	234..257	CDD:275380	7/22 (32%)
		leucine-rich repeat	258..280	CDD:275380	4/22 (18%)
		leucine-rich repeat	281..307	CDD:275380	8/25 (32%)
		leucine-rich repeat	309..357	CDD:275380	12/65 (18%)
		leucine-rich repeat	382..405	CDD:275380	11/28 (39%)
		leucine-rich repeat	406..429	CDD:275380	4/22 (18%)
		TPKR_C2	438..>478	CDD:387596	8/46 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BN8H
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H13497
Inparanoid	1	1.050	143	1.000	Inparanoid score	I3051
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243556at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto17262
orthoMCL	1	0.900	-	-		OOG6_114064
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.770